{"id":"https://openalex.org/W2414799251","doi":"https://doi.org/10.3760/cma.j.issn.0253-3766.2016.02.006","title":"[Optimization of the method to cultivate NK cells from abandoned white cells].","display_name":"[Optimization of the method to cultivate NK cells from abandoned white cells].","publication_year":2016,"publication_date":"2016-02-01","ids":{"openalex":"https://openalex.org/W2414799251","doi":"https://doi.org/10.3760/cma.j.issn.0253-3766.2016.02.006","mag":"2414799251","pmid":"https://pubmed.ncbi.nlm.nih.gov/26899329"},"language":"zh","primary_location":{"id":"pmid:26899329","doi":"https://doi.org/10.3760/cma.j.issn.0253-3766.2016.02.006","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26899329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua zhong liu za zhi [Chinese journal of oncology]","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060398527","display_name":"Baoli Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"B L Jin","raw_affiliation_strings":["Second School of Clinical Medicine, Shanxi Medical University, Taiyuan 030001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second School of Clinical Medicine, Shanxi Medical University, Taiyuan 030001, China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100532212","display_name":"Jiqiang Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137940","display_name":"Shanxi Dayi Hospital","ror":"https://ror.org/03tq2kc64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137940"]},{"id":"https://openalex.org/I4210158804","display_name":"Shanxi Academy of Medical Sciences","ror":"https://ror.org/04tshhm50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J Q Guo","raw_affiliation_strings":["Second Department of Medical Oncology, Shanxi Academy Of Medical Sciences, Shanxi Dayi Hospital, Tai yuan 030023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Medical Oncology, Shanxi Academy Of Medical Sciences, Shanxi Dayi Hospital, Tai yuan 030023, China","institution_ids":["https://openalex.org/I4210137940","https://openalex.org/I4210158804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017359010","display_name":"Yaping Han","orcid":"https://orcid.org/0000-0002-5839-225X","observed_orcids":["https://orcid.org/0000-0002-5839-225X"]},"institutions":[{"id":"https://openalex.org/I4210137940","display_name":"Shanxi Dayi Hospital","ror":"https://ror.org/03tq2kc64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137940"]},{"id":"https://openalex.org/I4210158804","display_name":"Shanxi Academy of Medical Sciences","ror":"https://ror.org/04tshhm50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y P Han","raw_affiliation_strings":["Second Department of Medical Oncology, Shanxi Academy Of Medical Sciences, Shanxi Dayi Hospital, Tai yuan 030023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Medical Oncology, Shanxi Academy Of Medical Sciences, Shanxi Dayi Hospital, Tai yuan 030023, China","institution_ids":["https://openalex.org/I4210137940","https://openalex.org/I4210158804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394166","display_name":"Fang Li","orcid":"https://orcid.org/0000-0001-9180-3615","observed_orcids":["https://orcid.org/0000-0001-9180-3615"]},"institutions":[{"id":"https://openalex.org/I4210137940","display_name":"Shanxi Dayi Hospital","ror":"https://ror.org/03tq2kc64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137940"]},{"id":"https://openalex.org/I4210158804","display_name":"Shanxi Academy of Medical Sciences","ror":"https://ror.org/04tshhm50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"F Li","raw_affiliation_strings":["Second Department of Medical Oncology, Shanxi Academy Of Medical Sciences, Shanxi Dayi Hospital, Tai yuan 030023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Medical Oncology, Shanxi Academy Of Medical Sciences, Shanxi Dayi Hospital, Tai yuan 030023, China","institution_ids":["https://openalex.org/I4210137940","https://openalex.org/I4210158804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080907776","display_name":"Qing Zhao","orcid":"https://orcid.org/0000-0003-3031-6746","observed_orcids":["https://orcid.org/0000-0003-3031-6746"]},"institutions":[{"id":"https://openalex.org/I4210137940","display_name":"Shanxi Dayi Hospital","ror":"https://ror.org/03tq2kc64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137940"]},{"id":"https://openalex.org/I4210158804","display_name":"Shanxi Academy of Medical Sciences","ror":"https://ror.org/04tshhm50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q Zhao","raw_affiliation_strings":["Second Department of Medical Oncology, Shanxi Academy Of Medical Sciences, Shanxi Dayi Hospital, Tai yuan 030023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Medical Oncology, Shanxi Academy Of Medical Sciences, Shanxi Dayi Hospital, Tai yuan 030023, China","institution_ids":["https://openalex.org/I4210137940","https://openalex.org/I4210158804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100625309","display_name":"Wenli Li","orcid":"https://orcid.org/0000-0003-1598-3217","observed_orcids":["https://orcid.org/0000-0003-1598-3217"]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W L Li","raw_affiliation_strings":["Second School of Clinical Medicine, Shanxi Medical University, Taiyuan 030001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second School of Clinical Medicine, Shanxi Medical University, Taiyuan 030001, China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063824547","display_name":"Demei Zhang","orcid":"https://orcid.org/0000-0001-7909-4676","observed_orcids":["https://orcid.org/0000-0001-7909-4676"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D M Zhang","raw_affiliation_strings":["Blood Center In Shanxi Province, Taiyuan 030024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Center In Shanxi Province, Taiyuan 030024, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103268343","display_name":"Hua Wang","orcid":"https://orcid.org/0000-0001-9405-4875","observed_orcids":["https://orcid.org/0000-0001-9405-4875"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Wang","raw_affiliation_strings":["Blood Center In Shanxi Province, Taiyuan 030024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Center In Shanxi Province, Taiyuan 030024, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100696430","display_name":"Junping Zhang","orcid":"https://orcid.org/0000-0002-7271-8615","observed_orcids":["https://orcid.org/0000-0002-7271-8615"]},"institutions":[{"id":"https://openalex.org/I4210137940","display_name":"Shanxi Dayi Hospital","ror":"https://ror.org/03tq2kc64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137940"]},{"id":"https://openalex.org/I4210158804","display_name":"Shanxi Academy of Medical Sciences","ror":"https://ror.org/04tshhm50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J P Zhang","raw_affiliation_strings":["Second Department of Medical Oncology, Shanxi Academy Of Medical Sciences, Shanxi Dayi Hospital, Tai yuan 030023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Medical Oncology, Shanxi Academy Of Medical Sciences, Shanxi Dayi Hospital, Tai yuan 030023, China","institution_ids":["https://openalex.org/I4210137940","https://openalex.org/I4210158804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05217473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"2","first_page":"105","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nk-cell-expansion","display_name":"NK cell expansion","score":0.859000027179718},{"id":"https://openalex.org/keywords/allogeneic-nk-cells","display_name":"allogeneic NK cells","score":0.9150000214576721},{"id":"https://openalex.org/keywords/nkp30","display_name":"NKp30","score":0.9549999833106995},{"id":"https://openalex.org/keywords/nkp46","display_name":"NKp46","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nkg2d","display_name":"NKG2D","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/raji-cells","display_name":"Raji cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ifn-gamma-secretion","display_name":"IFN-gamma secretion","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2781462264","wikidata":"https://www.wikidata.org/wiki/Q78482053","display_name":"CD16","level":5,"score":0.7566301822662354},{"id":"https://openalex.org/C2778867473","wikidata":"https://www.wikidata.org/wiki/Q17544382","display_name":"NKG2D","level":4,"score":0.7038381695747375},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.6018220782279968},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5924983024597168},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5722641348838806},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.559518039226532},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.542833685874939},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.5092548131942749},{"id":"https://openalex.org/C16232356","wikidata":"https://www.wikidata.org/wiki/Q4215980","display_name":"Raji cell","level":3,"score":0.4907780587673187},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.46039265394210815},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.4495564103126526},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4481007754802704},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.4393211901187897},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.4185762405395508},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.40862607955932617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37375351786613464},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3272150754928589},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.325166791677475},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30854251980781555},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2771753966808319},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.24800220131874084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1360790729522705},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.12932255864143372}],"mesh":[{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D019002","descriptor_name":"CD56 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:26899329","doi":"https://doi.org/10.3760/cma.j.issn.0253-3766.2016.02.006","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26899329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua zhong liu za zhi [Chinese journal of oncology]","raw_type":"Journal Article"},{"id":"mag:2414799251","doi":"https://doi.org/10.3760/cma.j.issn.0253-3766.2016.02.006","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26899329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3128753434","https://openalex.org/W2332442803","https://openalex.org/W2378893564","https://openalex.org/W3013979675","https://openalex.org/W2403629426","https://openalex.org/W2023017181","https://openalex.org/W6922990396","https://openalex.org/W2557061636","https://openalex.org/W2000813102","https://openalex.org/W2385428117"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Using":[1],"abandoned":[2,50,233],"white":[3,33,51,234],"cells":[4,14,27,34,52,122,142,175,206,228,235],"separated":[5,35],"from":[6,36,41,48,232],"preparation":[7],"of":[8,22,24,102,106,113,140,173,183,197,251,270],"blood":[9,37],"products":[10],"to":[11,18,98,245],"cultivate":[12],"NK":[13,26,174,184,205,227],"in":[15,145,151,157],"vitro,":[16],"and":[17,53,80,91,111,120,129,164,190,247,265],"optimize":[19],"the":[20,49,100,138,146,152,158,198,259,268],"method":[21],"cultivation":[23,237],"allogeneic":[25],"for":[28,55,135,238],"clinical":[29,271],"application.":[30,273],"METHODS:":[31],"Abandoned":[32],"production":[38],"were":[39,46,192],"collected":[40],"15":[42],"healthy":[43],"donors.":[44],"PBMCs":[45],"isolated":[47],"cultured":[54],"17":[56,136,239],"days":[57],"using":[58,125],"culture":[59],"bottles":[60],"as":[61],"previously":[62],"coated":[63,69,77,87],"antibodies":[64],"(group":[65],"CD3":[66,71,82,89,148,160],"mAb":[67,85,90],"was":[68,76,86,96,123,143,166,176,200,224,257,263],"with":[70,78,88,241],"mAb,":[72,149,155,163],"group":[73,81,147,153,159],"CD":[74],"16mAb":[75],"CD16mAb,":[79],"mAb+":[83,161],"CD16":[84,92,154,162],"mAb).":[93],"Flow":[94],"cytometry":[95],"used":[97],"determine":[99],"ratio":[101,221],"CD3(-)CD56(+)":[103,141],"cells,":[104,215],"expression":[105,181],"activated":[107,187],"cell":[108,185,249],"surface":[109,186],"receptors,":[110],"secretion":[112],"IFN-\u03b3.":[114],"The":[115,170,180,204],"anti-tumor":[116,260],"cytotoxicity":[117,127,211,261],"against":[118,213],"K562":[119,214],"Raji":[121],"determined":[124],"LDH":[126],"assay":[128],"flow":[130],"cytometry.":[131],"RESULTS:":[132],"After":[133],"expansion":[134,208],"days,":[137,240],"proportions":[139],"(15.19\u00b112.22)%":[144],"(83.63\u00b110.63)%":[150],"(49.40\u00b112.64)%":[156],"it":[165],"(16.34\u00b110.51)%":[167],"before":[168],"expansion.":[169],"total":[171,248],"number":[172,250],"more":[177,252],"than":[178,253],"10(9).":[179,254],"ratios":[182],"receptors":[188],"NKp30":[189],"NKp46":[191],"significantly":[193,202],"increased,":[194,264],"while":[195],"that":[196],"NKG2D":[199],"not":[201],"changed.":[203],"after":[207,236],"showed":[209],"high":[210],"activity":[212,256,262],"reaching":[216],"up":[217,244],"to(76.97\u00b13.16)%":[218],"when":[219],"effector-cell-to-target-cell":[220],"(E\u2236T":[222],"ratio)":[223],"40\u22361.":[225],"CONCLUSIONS:":[226],"can":[229],"be":[230],"obtained":[231],"a":[242],"purity":[243],"90%":[246],"Their":[255],"reinforced,":[258],"may":[266],"meet":[267],"standard":[269],"therapeutic":[272]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}