{"id":"https://openalex.org/W2414734835","doi":null,"title":"Binding of antithrombin to immobilized heparin under varying flow conditions.","display_name":"Binding of antithrombin to immobilized heparin under varying flow conditions.","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W2414734835","mag":"2414734835","pmid":"https://pubmed.ncbi.nlm.nih.gov/1763970"},"language":"en","primary_location":{"id":"pmid:1763970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1763970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial organs","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042254050","display_name":"Boris Pasche","orcid":"https://orcid.org/0000-0002-3750-7898","observed_orcids":["https://orcid.org/0000-0002-3750-7898"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"B Pasche","raw_affiliation_strings":["Department of Experimental Surgery, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Surgery, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060256289","display_name":"Graciela Elgue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Elgue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020665535","display_name":"Per Olsson","orcid":"https://orcid.org/0000-0002-0706-8783","observed_orcids":["https://orcid.org/0000-0002-0706-8783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Olsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075439931","display_name":"Johan Riesenfeld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Riesenfeld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111718271","display_name":"Anders Rasmuson","orcid":"https://orcid.org/0000-0003-0883-052X","observed_orcids":["https://orcid.org/0000-0003-0883-052X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Rasmuson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3169,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.81412698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"6","first_page":"481","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.996999979019165},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/wall-shear-stress","display_name":"wall shear stress","score":0.9369999766349792},{"id":"https://openalex.org/keywords/flow-velocity","display_name":"flow velocity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ionic-strength","display_name":"ionic strength","score":0.7749999761581421},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.5979999899864197},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"mathematical model","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.8157268166542053},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.8019214272499084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7245397567749023},{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.5820477604866028},{"id":"https://openalex.org/C187428577","wikidata":"https://www.wikidata.org/wiki/Q898396","display_name":"Ionic strength","level":3,"score":0.4912833571434021},{"id":"https://openalex.org/C179247698","wikidata":"https://www.wikidata.org/wiki/Q382799","display_name":"Affinity chromatography","level":3,"score":0.4902270436286926},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4814704954624176},{"id":"https://openalex.org/C2777015399","wikidata":"https://www.wikidata.org/wiki/Q4775337","display_name":"Antithrombotic","level":2,"score":0.4594496190547943},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4488697648048401},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4145756959915161},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2766987383365631},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13518404960632324},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.12669652700424194},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10119825601577759},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08714774250984192},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.062889963388443},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.06206950545310974},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1763970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1763970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial organs","raw_type":"Journal Article"},{"id":"mag:2414734835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1763970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2034148094","https://openalex.org/W2058577599","https://openalex.org/W2009848416","https://openalex.org/W2059839677","https://openalex.org/W4232415132","https://openalex.org/W2135305141","https://openalex.org/W2117127210","https://openalex.org/W2022789582","https://openalex.org/W2040252617","https://openalex.org/W358484293"],"abstract_inverted_index":{"Rheologic":[0],"factors":[1],"are":[2],"likely":[3],"to":[4,44,69,97,122,129,138,156],"influence":[5],"the":[6,14,17,23,30,82,89,95,110,118,130,146,153,157,160,164],"balance":[7],"between":[8],"thrombotic":[9],"and":[10,46,72],"antithrombotic":[11],"forces":[12],"at":[13,54],"level":[15],"of":[16,25,32,42,56,67,84,120,150],"vascular":[18],"wall.":[19],"In":[20],"this":[21],"study,":[22],"effects":[24],"flow-velocity/wall":[26],"shear":[27,62,93,112],"stress":[28,63,113],"on":[29,88],"interaction":[31],"antithrombin":[33],"(AT)":[34],"with":[35],"surface-immobilized":[36],"heparin":[37,48,74,124],"were":[38,136],"investigated.":[39],"The":[40],"binding":[41,66,96,106,119,128],"AT":[43,68,121,151],"low-affinity":[45,73,105,123],"high-affinity":[47,98,131],"could":[49],"be":[50],"discriminated":[51],"by":[52],"measurements":[53],"physiological":[55],"elevated":[57],"ionic":[58],"strength.":[59],"Under":[60],"low":[61],"conditions,":[64],"substantial":[65],"both":[70],"high-":[71],"was":[75,100],"observed,":[76],"in":[77,141,163],"relative":[78],"quantities":[79],"largely":[80],"reflecting":[81],"proportion":[83],"these":[85],"polysaccharide":[86],"populations":[87],"surface.":[90],"With":[91],"increasing":[92],"stress,":[94],"sites":[99],"relatively":[101],"constant,":[102],"while":[103,127],"total":[104],"decreased.":[107],"Furthermore,":[108],"under":[109,159],"highest":[111],"(greater":[114],"than":[115],"1,000":[116],"N/m2),":[117],"completely":[125],"disappeared":[126],"fraction":[132],"persisted.":[133],"These":[134],"results":[135],"related":[137],"values":[139],"obtained":[140],"a":[142],"mathematical":[143],"model,":[144],"describing":[145],"theoretical":[147],"maximum":[148],"transport":[149],"from":[152],"liquid":[154],"phase":[155],"surface":[158],"conditions":[161],"used":[162],"experimental":[165],"system.":[166]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
