{"id":"https://openalex.org/W2414733704","doi":null,"title":"Human immunodeficiency virus-associated wasting and mechanisms of cachexia associated with inflammation.","display_name":"Human immunodeficiency virus-associated wasting and mechanisms of cachexia associated with inflammation.","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W2414733704","mag":"2414733704","pmid":"https://pubmed.ncbi.nlm.nih.gov/9482543"},"language":"en","primary_location":{"id":"pmid:9482543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9482543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081164839","display_name":"Lyle L. Moldawer","orcid":"https://orcid.org/0000-0002-9041-9838","observed_orcids":["https://orcid.org/0000-0002-9041-9838"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L L Moldawer","raw_affiliation_strings":["Department of Surgery, University of Florida School of Medicine, Gainesville 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Florida School of Medicine, Gainesville 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058875385","display_name":"Fred R. Sattler","orcid":"https://orcid.org/0000-0002-1986-6803","observed_orcids":["https://orcid.org/0000-0002-1986-6803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F R Sattler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7554,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.83976425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"25","issue":"1 Suppl 1","first_page":"73","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.38179999589920044,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-associated-wasting","display_name":"HIV-associated wasting","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cachexia","display_name":"cachexia","score":0.949999988079071},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6990000009536743},{"id":"https://openalex.org/keywords/muscle-loss","display_name":"muscle mass loss","score":0.765999972820282},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8949999809265137},{"id":"https://openalex.org/keywords/anabolic-hormones","display_name":"anabolic hormones","score":0.8169999718666077},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.859000027179718},{"id":"https://openalex.org/keywords/energy-intake","display_name":"energy intake","score":0.7910000085830688},{"id":"https://openalex.org/keywords/anabolic-steroid-therapy","display_name":"anabolic steroid therapy","score":0.7910000085830688},{"id":"https://openalex.org/keywords/growth-hormone-therapy","display_name":"growth hormone therapy","score":0.8579999804496765},{"id":"https://openalex.org/keywords/appetite-stimulants","display_name":"appetite stimulants","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cytokine-antagonists","display_name":"cytokine antagonists","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C2777704314","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cachexia","level":3,"score":0.9196730852127075},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.9113366603851318},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7905203700065613},{"id":"https://openalex.org/C2911126609","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Wasting Syndrome","level":3,"score":0.675337553024292},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5910878777503967},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.5607587099075317},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.5140034556388855},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4923955202102661},{"id":"https://openalex.org/C2779390809","wikidata":"https://www.wikidata.org/wiki/Q309438","display_name":"Anabolic steroid","level":3,"score":0.4615817666053772},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.40589940547943115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33189791440963745},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30840766429901123}],"mesh":[{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019247","descriptor_name":"HIV Wasting Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D019247","descriptor_name":"HIV Wasting Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9482543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9482543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Journal Article"},{"id":"mag:2414733704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9482543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4380577989","display_name":"METABOLIC/ENDOCRINE DYSREGULATION IN HIV","funder_award_id":"R01DK049308","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2105076981","https://openalex.org/W2405025308","https://openalex.org/W2037196988","https://openalex.org/W2105755717","https://openalex.org/W7097009554","https://openalex.org/W2143697404","https://openalex.org/W2096488224","https://openalex.org/W7098773711","https://openalex.org/W2078688551","https://openalex.org/W2027275595"],"abstract_inverted_index":{"Profound":[0],"weight":[1],"loss":[2],"and":[3,20,43,69,94,103,126],"progressive":[4],"depletion":[5],"of":[6,13,27,45,64,107,122,132],"muscle":[7],"mass":[8],"is":[9],"a":[10],"common":[11],"sequela":[12],"chronic":[14],"diseases":[15],"such":[16],"as":[17],"cancer,":[18],"tuberculosis,":[19],"human":[21,95],"immunodeficiency":[22],"virus":[23],"(HIV)":[24],"infection.":[25],"Studies":[26],"HIV-associated":[28,80],"wasting":[29,54,81,138],"have":[30,60,110],"revealed":[31,61],"several":[32],"possible":[33],"mechanisms.":[34],"Alterations":[35],"in":[36,55,116,130],"anabolic":[37,92],"hormones,":[38],"energy":[39,41],"intake,":[40],"expenditure,":[42],"production":[44],"proinflammatory":[46],"cytokines,":[47],"which":[48],"cause":[49],"cachexia,":[50],"may":[51],"contribute":[52],"to":[53,128],"HIV-infected":[56],"patients.":[57],"These":[58],"studies":[59],"the":[62,65,70],"complexity":[63],"interactions":[66],"between":[67],"cytokines":[68],"hormones":[71],"that":[72],"typically":[73],"regulate":[74],"catabolic-anabolic":[75],"homeostasis.":[76],"Despite":[77],"this":[78],"complexity,":[79],"should":[82,119],"be":[83],"manageable.":[84],"Several":[85],"strategies":[86,125],"are":[87],"currently":[88],"under":[89],"investigation,":[90],"including":[91],"steroid":[93],"growth":[96],"hormone":[97],"therapy,":[98],"appetite":[99],"stimulants,":[100],"nutritional":[101],"supplementation,":[102],"cytokine":[104],"antagonists.":[105],"Some":[106],"these":[108,117],"approaches":[109],"shown":[111],"early":[112],"promise.":[113],"Further":[114],"research":[115],"areas":[118],"facilitate":[120],"development":[121],"effective":[123],"intervention":[124],"lead":[127],"improvements":[129],"quality":[131],"life":[133],"for":[134],"patients":[135],"suffering":[136],"from":[137],"syndromes.":[139]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}