{"id":"https://openalex.org/W2414729643","doi":null,"title":"Activation of protease activity in rat peritoneal macrophages in protein deficiency: characterization of cathepsin D.","display_name":"Activation of protease activity in rat peritoneal macrophages in protein deficiency: characterization of cathepsin D.","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W2414729643","mag":"2414729643","pmid":"https://pubmed.ncbi.nlm.nih.gov/8979498"},"language":"en","primary_location":{"id":"pmid:8979498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8979498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109867121","display_name":"S.C. Smitha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1329621470","display_name":"Bhabha Atomic Research Centre","ror":"https://ror.org/05w6wfp17","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1329621470","https://openalex.org/I2799351866","https://openalex.org/I3149292468"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S Smitha","raw_affiliation_strings":["Food Technology Division, Bhabha Atomic Research Centre, Trombay, Bombay, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Technology Division, Bhabha Atomic Research Centre, Trombay, Bombay, India","institution_ids":["https://openalex.org/I1329621470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000671015","display_name":"J. P. Machaiah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Machaiah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"P M Nair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M Nair","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"7","first_page":"641","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cathepsin-d","display_name":"cathepsin D","score":0.9629999995231628},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.9210000038146973},{"id":"https://openalex.org/keywords/protein-deficiency","display_name":"protein deficiency","score":0.9639999866485596},{"id":"https://openalex.org/keywords/aspartic-protease","display_name":"aspartic protease","score":0.8399999737739563},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.5270000100135803},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7609999775886536},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/nutrient-stress","display_name":"nutritional stress","score":0.5}],"concepts":[{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.7859348058700562},{"id":"https://openalex.org/C173633252","wikidata":"https://www.wikidata.org/wiki/Q3663475","display_name":"Cathepsin D","level":3,"score":0.7087677717208862},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.7057388424873352},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.624668538570404},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5436342358589172},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5425652861595154},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.534538984298706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4945201575756073},{"id":"https://openalex.org/C28021979","wikidata":"https://www.wikidata.org/wiki/Q14911946","display_name":"Cathepsin B","level":3,"score":0.4786842465400696},{"id":"https://openalex.org/C174937957","wikidata":"https://www.wikidata.org/wiki/Q18248582","display_name":"Cathepsin E","level":5,"score":0.4641495943069458},{"id":"https://openalex.org/C198684833","wikidata":"https://www.wikidata.org/wiki/Q2823748","display_name":"Specific activity","level":3,"score":0.4135405421257019},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3758932650089264},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33323854207992554},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28521543741226196},{"id":"https://openalex.org/C34695024","wikidata":"https://www.wikidata.org/wiki/Q14902030","display_name":"Cathepsin O","level":4,"score":0.2117728888988495}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002402","descriptor_name":"Cathepsin D","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002402","descriptor_name":"Cathepsin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002402","descriptor_name":"Cathepsin D","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011488","descriptor_name":"Protein Deficiency","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8979498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8979498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},{"id":"mag:2414729643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8979498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992319564","https://openalex.org/W2085448192","https://openalex.org/W1770833849","https://openalex.org/W2092725267","https://openalex.org/W1525574052","https://openalex.org/W1780228744","https://openalex.org/W1542552479","https://openalex.org/W2070817769","https://openalex.org/W2331447604","https://openalex.org/W2418681263"],"abstract_inverted_index":{"Rat":[0],"peritoneal":[1],"macrophages":[2,40],"contained":[3],"high":[4],"proteolytic":[5],"activity":[6,75,139],"that":[7,78],"was":[8,36,55],"significantly":[9],"enhanced":[10,155],"under":[11],"the":[12,29,39,65,80,84,91,95,105,117,132,138,145,154],"stress":[13],"induced":[14],"by":[15],"protein":[16,45,48,51,146],"deficiency.":[17],"The":[18,61,99],"aspartyl":[19],"protease":[20,32],"cathepsin":[21,62,114],"D":[22,63,115],"which":[23,123],"has":[24],"been":[25],"known":[26],"to":[27,77],"be":[28,150],"most":[30],"active":[31,111],"in":[33,116,120,125,128,137,144],"endocytic":[34],"processes":[35],"extracted":[37],"from":[38,42,64,79,93],"recovered":[41],"control":[43,66],"(20%":[44],"fed)":[46,52],"and":[47,54,58,72,87],"deficient":[49,81,118,147],"(4%":[50],"rats":[53,148],"affinity":[56],"purified":[57],"characterized":[59],"further.":[60],"sample":[67],"exhibited":[68],"better":[69],"recovery,":[70],"purification":[71],"higher":[73],"specific":[74],"compared":[76],"groups.":[82],"Apparently":[83],"pH":[85],"optima":[86],"heat":[88],"stability":[89],"of":[90,107,110,113,131,140,157],"enzyme":[92],"both":[94],"groups":[96],"were":[97],"similar.":[98],"SDS":[100],"PAGE":[101],"profile":[102],"clearly":[103],"indicated":[104],"presence":[106],"greater":[108],"amounts":[109],"forms":[112],"samples":[119],"vivo":[121],"itself":[122],"reflected":[124],"a":[126],"reduction":[127],"Km":[129],"value":[130],"enzyme.":[133],"Subtle":[134],"differences":[135],"observed":[136],"these":[141],"macrophage":[142,158],"proteases":[143],"may":[149],"partly":[151],"responsible":[152],"for":[153],"degradation":[156],"membrane":[159],"proteins":[160],"reported":[161],"earlier.":[162]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
