{"id":"https://openalex.org/W2414724730","doi":null,"title":"Analysis of phenotypic abnormalities and cell fate changes caused by dominant activated and dominant negative forms of the Notch receptor in Drosophila development.","display_name":"Analysis of phenotypic abnormalities and cell fate changes caused by dominant activated and dominant negative forms of the Notch receptor in Drosophila development.","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W2414724730","mag":"2414724730","pmid":"https://pubmed.ncbi.nlm.nih.gov/8076207"},"language":"en","primary_location":{"id":"pmid:8076207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8076207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033906250","display_name":"Ilaria Rebay","orcid":"https://orcid.org/0000-0002-2444-3864","observed_orcids":["https://orcid.org/0000-0002-2444-3864"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I Rebay","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, Connecticut 06536-0812"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, Connecticut 06536-0812","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103451438","display_name":"Mark Fortini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Fortini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004223352","display_name":"Spyros Artavanis\u2010Tsakonas","orcid":"https://orcid.org/0000-0001-9112-1518","observed_orcids":["https://orcid.org/0000-0001-9112-1518"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Artavanis-Tsakonas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.18755852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"316","issue":"9","first_page":"1097","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch-receptor","display_name":"Notch receptor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/drosophila-development","display_name":"Drosophila development","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cell-fate-specification","display_name":"cell fate specification","score":0.9670000076293945},{"id":"https://openalex.org/keywords/egf-like-repeats","display_name":"EGF-like repeats","score":0.7609999775886536},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.7419999837875366},{"id":"https://openalex.org/keywords/deletion-mutants","display_name":"deletion mutants","score":0.7319999933242798},{"id":"https://openalex.org/keywords/compound-eye","display_name":"compound eye","score":0.5809999704360962},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/gain-of-function-mutations","display_name":"gain-of-function mutations","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.8967472314834595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7982357740402222},{"id":"https://openalex.org/C202769670","wikidata":"https://www.wikidata.org/wiki/Q4045508","display_name":"Notch proteins","level":4,"score":0.7312289476394653},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.6158775687217712},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5720234513282776},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5562369227409363},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.532991349697113},{"id":"https://openalex.org/C2909722775","wikidata":"https://www.wikidata.org/wiki/Q942537","display_name":"Compound eye","level":2,"score":0.5012392997741699},{"id":"https://openalex.org/C113241181","wikidata":"https://www.wikidata.org/wiki/Q24784174","display_name":"Ankyrin repeat","level":3,"score":0.49990010261535645},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.48815351724624634},{"id":"https://openalex.org/C153660203","wikidata":"https://www.wikidata.org/wiki/Q24723491","display_name":"EGF-like domain","level":4,"score":0.48352837562561035},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40312641859054565},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.22284168004989624},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.18492171168327332},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007301","descriptor_name":"Insect Hormones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8076207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8076207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie","raw_type":"Journal Article"},{"id":"mag:2414724730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8076207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2064049283","https://openalex.org/W1990045619","https://openalex.org/W1927705215","https://openalex.org/W2419295429","https://openalex.org/W4237322414","https://openalex.org/W1887673845","https://openalex.org/W64962480","https://openalex.org/W2187570082","https://openalex.org/W2154185559","https://openalex.org/W2086117943"],"abstract_inverted_index":{"The":[0,15,80],"Notch":[1,16,49,75,88,124,146,193,212,224,250,265],"gene":[2,76],"of":[3,23,59,69,73,82,86,97,118,122,139,144,151,177,191,210,222],"Drosophila":[4,123,200],"plays":[5],"an":[6,34,126,189,248],"important":[7],"role":[8],"in":[9,46,90,198,213,225,269],"cell":[10,215,241],"fate":[11],"specification":[12],"throughout":[13],"development.":[14],"protein":[17,89,179,251],"contains":[18],"a":[19,95,178],"large":[20],"extracellular":[21,120],"domain":[22,36,121,255],"36":[24],"EGF-like":[25],"repeats":[26,32],"as":[27,29,129],"well":[28],"3":[30],"Notch/lin-12":[31],"and":[33,161],"intracellular":[35,182],"with":[37,158],"6":[38],"cdc10/ankyrin":[39],"repeats,":[40],"motifs":[41],"which":[42,63,100],"are":[43],"highly":[44],"conserved":[45],"several":[47],"vertebrate":[48,152],"homologues":[50],"[1-7].":[51],"In":[52,169],"this":[53],"review":[54],"we":[55],"summarize":[56],"the":[57,70,74,87,107,113,119,145,199,226,253,259,262],"results":[58,185],"two":[60],"recent":[61],"studies":[62],"attempt":[64],"to":[65,134,237,244,258],"establish":[66],"structure-function":[67],"relationships":[68],"various":[71,83],"domains":[72,85],"product":[77],"[8,":[78],"9].":[79],"functions":[81],"structural":[84],"vivo":[91],"were":[92,186],"investigated":[93],"using":[94],"series":[96],"deletion":[98],"mutants":[99],"have":[101,155],"been":[102,156],"ectopically":[103],"expressed":[104],"either":[105,238],"under":[106,112],"hsp70":[108],"heat-shock":[109],"promoter":[110],"or":[111,142,243],"sevenless":[114],"eye-specific":[115],"promoter.":[116],"Truncation":[117],"produces":[125],"activated":[127,192,223,249],"receptor":[128],"judged":[130],"by":[131,188],"its":[132],"ability":[133],"cause":[135],"phenotypes":[136,173],"matching":[137],"those":[138],"gain-of-function":[140],"alleles":[141],"duplications":[143],"locus":[147],"[8].":[148],"Equivalent":[149],"truncations":[150],"Notch-related":[153],"proteins":[154],"associated":[157],"malignant":[159],"neoplasms":[160],"other":[162],"developmental":[163],"abnormalities":[164],"[3,":[165],"6,":[166],"10,":[167],"11].":[168],"contrast,":[170],"dominant":[171],"negative":[172],"result":[174],"from":[175],"overexpression":[176,209,221],"lacking":[180,252],"most":[181],"sequences.":[183],"These":[184],"extended":[187],"analysis":[190],"function":[194],"at":[195],"single-cell":[196],"resolution":[197],"compound":[201],"eye":[202],"[9].":[203],"It":[204],"was":[205],"shown":[206],"that":[207,264],"while":[208],"full-length":[211],"defined":[214],"types":[216],"has":[217],"no":[218],"apparent":[219],"effects,":[220],"same":[227],"cells":[228],"transiently":[229],"blocks":[230],"their":[231],"proper":[232],"cell-fate":[233],"commitment,":[234],"causing":[235],"them":[236],"adopt":[239],"incorrect":[240],"fates":[242],"differentiate":[245],"incompletely.":[246],"Moreover,":[247],"transmembrane":[254],"is":[256],"translocated":[257],"nucleus,":[260],"raising":[261],"possibility":[263],"may":[266],"participate":[267],"directly":[268],"nuclear":[270],"events.":[271]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}