{"id":"https://openalex.org/W2414511545","doi":null,"title":"Clearance and organ localization of particles and soluble complexes in mice with circulating complexes.","display_name":"Clearance and organ localization of particles and soluble complexes in mice with circulating complexes.","publication_year":1984,"publication_date":"1984-08-01","ids":{"openalex":"https://openalex.org/W2414511545","mag":"2414511545","pmid":"https://pubmed.ncbi.nlm.nih.gov/6746002","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454682"},"language":"en","primary_location":{"id":"pmid:6746002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6746002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1454682/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058020426","display_name":"Stuart D. Carter","orcid":"https://orcid.org/0000-0002-3585-9400","observed_orcids":["https://orcid.org/0000-0002-3585-9400"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S D Carter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110109176","display_name":"Fionula M. Brennan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F M Brennan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108601528","display_name":"S A Grace","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Grace","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111661912","display_name":"Chris J. Elson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C J Elson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.145,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.37286992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"52","issue":"4","first_page":"761","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.16110000014305115,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-immune-complexes","display_name":"circulating immune complexes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/immune-complex-clearance","display_name":"immune complex clearance","score":0.8769999742507935},{"id":"https://openalex.org/keywords/organ-localization","display_name":"organ localization","score":0.7860000133514404},{"id":"https://openalex.org/keywords/ovalbumin","display_name":"ovalbumin","score":0.7099999785423279},{"id":"https://openalex.org/keywords/sheep-red-blood-cells","display_name":"sheep red blood cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/polyvinylpyrrolidone","display_name":"polyvinylpyrrolidone","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hepatic-uptake","display_name":"hepatic uptake","score":0.8569999933242798},{"id":"https://openalex.org/keywords/splenic-uptake","display_name":"splenic uptake","score":0.996999979019165},{"id":"https://openalex.org/keywords/mononuclear-phagocytes","display_name":"mononuclear phagocytes","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.8223775625228882},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.7479379177093506},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5563228130340576},{"id":"https://openalex.org/C19702531","wikidata":"https://www.wikidata.org/wiki/Q929966","display_name":"Mononuclear phagocyte system","level":2,"score":0.4477500915527344},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40102171897888184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33517932891845703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3346934914588928},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23961734771728516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12366348505020142},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011205","descriptor_name":"Povidone","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011205","descriptor_name":"Povidone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:6746002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6746002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1454682","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1454682/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"mag:2414511545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6746002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1454682","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1454682/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W17103839","https://openalex.org/W106754946","https://openalex.org/W1482799918","https://openalex.org/W1487638043","https://openalex.org/W1500181036","https://openalex.org/W1506082652","https://openalex.org/W1524241839","https://openalex.org/W1529298294","https://openalex.org/W1529835096","https://openalex.org/W1542918343","https://openalex.org/W1717442359","https://openalex.org/W1968724525","https://openalex.org/W1997235073","https://openalex.org/W2002880428","https://openalex.org/W2039634043","https://openalex.org/W2061401070","https://openalex.org/W2080580789","https://openalex.org/W2092082027","https://openalex.org/W2119198419","https://openalex.org/W2162824399","https://openalex.org/W2315955202","https://openalex.org/W2411103057","https://openalex.org/W2416491170","https://openalex.org/W4313313436","https://openalex.org/W4313317795"],"related_works":["https://openalex.org/W1482799918","https://openalex.org/W1558721940","https://openalex.org/W4313317795","https://openalex.org/W2054447939","https://openalex.org/W329626820","https://openalex.org/W2414871177","https://openalex.org/W7099841595","https://openalex.org/W1512969686","https://openalex.org/W2067421201","https://openalex.org/W1968724525"],"abstract_inverted_index":{"The":[0],"clearance":[1,81],"and":[2,22,40,54],"organ":[3],"localization":[4],"of":[5,8,32,35,49,57,63,80,82,99,109],"a":[6],"number":[7],"substances":[9],"cleared":[10],"by":[11,126],"either":[12],"Fc-dependent":[13,127],"or":[14,66],"-independent":[15],"mechanisms":[16],"was":[17,69,88,96],"studied":[18],"in":[19,23,71,90],"normal":[20],"mice":[21,24,73,91,110],"with":[25,74,92,111],"endogenously":[26],"produced":[27],"persistent":[28,112],"circulating":[29,113],"complexes.":[30,76],"Clearance":[31],"covalent":[33],"dimers":[34],"mouse":[36,59],"IgG,":[37],"chicken":[38,64],"IgG":[39,60,65],"ovalbumin":[41,67],"were":[42],"no":[43],"different":[44],"between":[45],"the":[46,72,78,106],"two":[47],"groups":[48],"mice.":[50],"By":[51],"contrast,":[52],"hepatic":[53,97],"splenic":[55],"uptake":[56,98],"dimeric":[58],"(but":[61],"not":[62],"dimer)":[68],"impaired":[70],"persisting":[75,93],"Surprisingly":[77],"rate":[79],"sheep":[83],"red":[84],"blood":[85],"cells":[86],"(SRBC)":[87],"increased":[89],"complexes":[94,114,125],"as":[95],"polyvinyl":[100],"pyrrolidone.":[101],"It":[102],"is":[103,129],"suggested":[104],"that":[105],"mononuclear":[107],"phagocytes":[108],"are":[115],"non-specifically":[116],"stimulated":[117],"while":[118],"their":[119],"ability":[120],"to":[121],"take":[122],"up":[123],"soluble":[124],"attachment":[128],"selectively":[130],"impaired.":[131]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}