{"id":"https://openalex.org/W2413802193","doi":"https://doi.org/10.1177/135965350501000112","title":"Changes in Mitochondrial Rna Production in Cells Treated with Nucleoside Analogues","display_name":"Changes in Mitochondrial Rna Production in Cells Treated with Nucleoside Analogues","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2413802193","doi":"https://doi.org/10.1177/135965350501000112","mag":"2413802193","pmid":"https://pubmed.ncbi.nlm.nih.gov/15751778"},"language":"en","primary_location":{"id":"doi:10.1177/135965350501000112","doi":"https://doi.org/10.1177/135965350501000112","is_oa":false,"landing_page_url":"https://doi.org/10.1177/135965350501000112","pdf_url":null,"source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11380/310422","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071827163","display_name":"Lorenzo Galluzzi","orcid":"https://orcid.org/0000-0003-2257-8500","observed_orcids":["https://orcid.org/0000-0003-2257-8500"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Galluzzi","raw_affiliation_strings":["Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053444531","display_name":"Marcello Pinti","orcid":"https://orcid.org/0000-0001-9118-1262","observed_orcids":["https://orcid.org/0000-0001-9118-1262"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marcello Pinti","raw_affiliation_strings":["Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019189838","display_name":"Leonarda Troiano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Leonarda Troiano","raw_affiliation_strings":["Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088165216","display_name":"Nicole Prada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicole Prada","raw_affiliation_strings":["Department of Biopathology and Biomedical Methodologies, University of Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopathology and Biomedical Methodologies, University of Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011006690","display_name":"Milena Nasi","orcid":"https://orcid.org/0000-0003-3079-8001","observed_orcids":["https://orcid.org/0000-0003-3079-8001"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Milena Nasi","raw_affiliation_strings":["Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058735593","display_name":"Roberta Ferraresi","orcid":"https://orcid.org/0000-0001-6850-0237","observed_orcids":["https://orcid.org/0000-0001-6850-0237"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Ferraresi","raw_affiliation_strings":["Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051777812","display_name":"Paolo Salomoni","orcid":"https://orcid.org/0000-0001-6885-8116","observed_orcids":["https://orcid.org/0000-0001-6885-8116"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paolo Salomoni","raw_affiliation_strings":["Laboratory of Genetic Instability II, MRC Toxicology Unit, University of Leicester, Leicester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetic Instability II, MRC Toxicology Unit, University of Leicester, Leicester, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082570595","display_name":"Cristina Mussini","orcid":"https://orcid.org/0000-0003-1842-5368","observed_orcids":["https://orcid.org/0000-0003-1842-5368"]},"institutions":[{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Mussini","raw_affiliation_strings":["Infectious Diseases Clinic, University Hospital and Azienda Policlinico, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Clinic, University Hospital and Azienda Policlinico, Modena, Italy","institution_ids":["https://openalex.org/I4210109058"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083279701","display_name":"Andrea Cossarizza","orcid":"https://orcid.org/0000-0002-5381-1558","observed_orcids":["https://orcid.org/0000-0002-5381-1558"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Andrea Cossarizza","raw_affiliation_strings":["Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy","Department of Biopathology and Biomedical Methodologies, University of Palermo, Palermo, Italy","Infectious Diseases Clinic, University Hospital and Azienda Policlinico, Modena, Italy","Laboratory of Genetic Instability II, MRC Toxicology Unit, University of Leicester, Leicester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Department of Biopathology and Biomedical Methodologies, University of Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Infectious Diseases Clinic, University Hospital and Azienda Policlinico, Modena, Italy","institution_ids":["https://openalex.org/I4210109058"]},{"raw_affiliation_string":"Laboratory of Genetic Instability II, MRC Toxicology Unit, University of Leicester, Leicester, UK","institution_ids":["https://openalex.org/I153648349"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":3.4182,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.92427718,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"191","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.20960000157356262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-rna","display_name":"mitochondrial RNA","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mitochondrial-toxicity","display_name":"mitochondrial toxicity","score":0.6800000071525574},{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitors","display_name":"nucleoside reverse transcriptase inhibitors","score":0.9240000247955322},{"id":"https://openalex.org/keywords/stavudine","display_name":"stavudine","score":0.984000027179718},{"id":"https://openalex.org/keywords/didanosine","display_name":"didanosine","score":0.984000027179718},{"id":"https://openalex.org/keywords/zidovudine","display_name":"zidovudine","score":1.0},{"id":"https://openalex.org/keywords/antiretroviral-drugs","display_name":"antiretroviral drugs","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mtdna-content","display_name":"mtDNA content","score":0.8169999718666077},{"id":"https://openalex.org/keywords/nd1-gene","display_name":"ND1 gene","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cytb-gene","display_name":"cytb gene","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nd6-gene","display_name":"ND6 gene","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hut-78-cells","display_name":"HUT-78 cells","score":0.8529999852180481},{"id":"https://openalex.org/keywords/ccrf-cem-cells","display_name":"CCRF-CEM cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.9779999852180481}],"concepts":[{"id":"https://openalex.org/C2777447569","wikidata":"https://www.wikidata.org/wiki/Q422606","display_name":"Didanosine","level":5,"score":0.9091561436653137},{"id":"https://openalex.org/C2779889181","wikidata":"https://www.wikidata.org/wiki/Q423984","display_name":"Stavudine","level":5,"score":0.8982603549957275},{"id":"https://openalex.org/C2780216070","wikidata":"https://www.wikidata.org/wiki/Q198504","display_name":"Zidovudine","level":4,"score":0.6342520117759705},{"id":"https://openalex.org/C2777071529","wikidata":"https://www.wikidata.org/wiki/Q12796879","display_name":"Mitochondrial toxicity","level":3,"score":0.6321029663085938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5577399134635925},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5261777639389038},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.5063849687576294},{"id":"https://openalex.org/C2909970146","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Nucleoside Reverse Transcriptase Inhibitor","level":5,"score":0.49583467841148376},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4805629551410675},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.4705144464969635},{"id":"https://openalex.org/C2780866839","wikidata":"https://www.wikidata.org/wiki/Q2344582","display_name":"Zalcitabine","level":5,"score":0.4575258195400238},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.4534270465373993},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.42152833938598633},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4139830470085144},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4071292281150818},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3651331961154938},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35843658447265625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3005492687225342},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.29207643866539},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23654326796531677},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.16340932250022888},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14043384790420532},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0913187563419342},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077278","descriptor_name":"RNA, Mitochondrial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016049","descriptor_name":"Didanosine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018119","descriptor_name":"Stavudine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1177/135965350501000112","doi":"https://doi.org/10.1177/135965350501000112","is_oa":false,"landing_page_url":"https://doi.org/10.1177/135965350501000112","pdf_url":null,"source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},{"id":"pmid:15751778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15751778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral therapy","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:75963","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/75963/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ANTIVIR THER , 10 (1) 191 - 195. (2005)","raw_type":"Article"},{"id":"pmh:oai:iris.unimore.it:11380/310422","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/310422","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:iris.unimore.it:11380/310422","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/310422","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W79015206","https://openalex.org/W1717575653","https://openalex.org/W1998919595","https://openalex.org/W2008681391","https://openalex.org/W2016061271","https://openalex.org/W2021113762","https://openalex.org/W2023572990","https://openalex.org/W2035780456","https://openalex.org/W2055767432","https://openalex.org/W2064879869","https://openalex.org/W2072253842","https://openalex.org/W2086317930","https://openalex.org/W2106809159","https://openalex.org/W2109291482","https://openalex.org/W2117915375","https://openalex.org/W2128636294","https://openalex.org/W2129398678","https://openalex.org/W2139807726","https://openalex.org/W2145039204","https://openalex.org/W2330861176","https://openalex.org/W2405500316","https://openalex.org/W2423137336","https://openalex.org/W2804007336"],"related_works":["https://openalex.org/W202332265","https://openalex.org/W2105595131","https://openalex.org/W2145039204","https://openalex.org/W2389554704","https://openalex.org/W2019894676","https://openalex.org/W1972970986","https://openalex.org/W2171494599","https://openalex.org/W2126327126","https://openalex.org/W7098758231","https://openalex.org/W2090950823"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"investigate":[2],"mitochondrial":[3],"(mt)":[4],"toxicity":[5],"of":[6,20,26,37,51,105],"antiretroviral":[7],"drugs":[8],"further,":[9],"we":[10,176],"developed":[11,178],"a":[12,122],"novel":[13],"real-time":[14,85],"PCR-based":[15],"assay":[16],"for":[17,75,195],"the":[18,24,35,46,49,55],"quantification":[19],"mtRNA.":[21],"We":[22],"analysed":[23],"effects":[25],"stavudine":[27],"(d4T),":[28],"didanosine":[29],"(ddl)":[30],"and":[31,44,63,83,92,98,172,191],"zidovudine":[32],"(AZT)":[33],"on":[34,199],"production":[36,47,141],"mtRNAs":[38,95,106],"in":[39,54,108,116,127,139,148],"different":[40,69,94,109],"human":[41],"cell":[42,110],"lines":[43],"compared":[45],"with":[48,130,134],"amount":[50],"mtDNA":[52,91,149,159,188],"present":[53],"same":[56],"cells.":[57],"MATERIALS":[58],"AND":[59],"METHODS:":[60],"HUT78,":[61],"CEM":[62],"U937":[64],"cells":[65,117,128],"were":[66,81],"exposed":[67,118],"to":[68,89,119,146],"nucleoside":[70],"reverse":[71],"transcriptase":[72],"inhibitors":[73],"(NRTIs)":[74],"7":[76],"days.":[77],"Thereafter,":[78],"nucleic":[79],"acids":[80],"isolated":[82],"Taqman-based":[84],"PCR":[86],"was":[87,114,125],"used":[88,194],"quantify":[90],"three":[93],"(ND1,":[96],"CYTB":[97],"ND6":[99],"gene":[100],"products).":[101],"RESULTS:":[102],"Different":[103],"amounts":[104],"exist":[107],"lines.":[111],"When":[112],"mtRNA":[113,140,156,170],"measured":[115],"an":[120],"NRTI,":[121],"marked":[123],"decrease":[124],"observed":[126,185],"treated":[129],"d4T,":[131,162],"but":[132,157,163],"not":[133,143,158,164,184],"ddl":[135,165],"or":[136,166],"AZT.":[137],"Changes":[138],"did":[142],"always":[144],"correspond":[145],"modifications":[147],"content:":[150],"1":[151],"microM":[152],"d4T":[153],"significantly":[154,168],"changed":[155],"content.":[160],"CONCLUSIONS:":[161],"AZT,":[167],"alters":[169],"quantity":[171],"quality.":[173],"The":[174],"method":[175],"have":[177],"can":[179,192],"reveal":[180],"changes":[181],"that":[182],"are":[183],"by":[186],"measuring":[187],"content":[189],"only,":[190],"be":[193],"ex":[196],"vivo":[197],"studies":[198],"drug":[200],"toxicity.":[201]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
