{"id":"https://openalex.org/W2413726348","doi":"https://doi.org/10.1002/adhm.201600126","title":"Phospholipid End\u2010Capped Acid\u2010Degradable Polyurethane Micelles for Intracellular Delivery of Cancer Therapeutics","display_name":"Phospholipid End\u2010Capped Acid\u2010Degradable Polyurethane Micelles for Intracellular Delivery of Cancer Therapeutics","publication_year":2016,"publication_date":"2016-06-01","ids":{"openalex":"https://openalex.org/W2413726348","doi":"https://doi.org/10.1002/adhm.201600126","mag":"2413726348","pmid":"https://pubmed.ncbi.nlm.nih.gov/27245616"},"language":"en","primary_location":{"id":"doi:10.1002/adhm.201600126","doi":"https://doi.org/10.1002/adhm.201600126","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.201600126","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074494350","display_name":"Johnson V. John","orcid":"https://orcid.org/0000-0001-8105-0808","observed_orcids":["https://orcid.org/0000-0001-8105-0808"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Johnson V. John","raw_affiliation_strings":["BK21 PLUS Center for Advanced Chemical Technology Department of Polymer Science and Engineering Pusan National University  Busan 609\u2013735 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 PLUS Center for Advanced Chemical Technology Department of Polymer Science and Engineering Pusan National University  Busan 609\u2013735 Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017064025","display_name":"Reju George Thomas","orcid":"https://orcid.org/0000-0001-9908-4619","observed_orcids":["https://orcid.org/0000-0001-9908-4619"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]},{"id":"https://openalex.org/I4210148121","display_name":"Chonnam National University Hwasun Hospital","ror":"https://ror.org/054gh2b75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150","https://openalex.org/I4210148121"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Reju George Thomas","raw_affiliation_strings":["Department of Radiology Hwasun Hospital Chonnam National University  Hwasun 519\u2013763 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology Hwasun Hospital Chonnam National University  Hwasun 519\u2013763 Republic of Korea","institution_ids":["https://openalex.org/I111277659","https://openalex.org/I4210148121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042900583","display_name":"Hye Ri Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Ri Lee","raw_affiliation_strings":["BK21 PLUS Center for Advanced Chemical Technology Department of Polymer Science and Engineering Pusan National University  Busan 609\u2013735 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 PLUS Center for Advanced Chemical Technology Department of Polymer Science and Engineering Pusan National University  Busan 609\u2013735 Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115601812","display_name":"Hongyu Chen","orcid":"https://orcid.org/0000-0002-5325-9249","observed_orcids":["https://orcid.org/0000-0002-5325-9249"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Hongyu Chen","raw_affiliation_strings":["Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 63737 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 63737 Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020509355","display_name":"Yong Yeon Jeong","orcid":"https://orcid.org/0000-0001-6096-3130","observed_orcids":["https://orcid.org/0000-0001-6096-3130"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]},{"id":"https://openalex.org/I4210148121","display_name":"Chonnam National University Hwasun Hospital","ror":"https://ror.org/054gh2b75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150","https://openalex.org/I4210148121"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yong Yeon Jeong","raw_affiliation_strings":["Department of Radiology Hwasun Hospital Chonnam National University  Hwasun 519\u2013763 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology Hwasun Hospital Chonnam National University  Hwasun 519\u2013763 Republic of Korea","institution_ids":["https://openalex.org/I111277659","https://openalex.org/I4210148121"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082869373","display_name":"Il Kim","orcid":"https://orcid.org/0000-0001-8047-7543","observed_orcids":["https://orcid.org/0000-0001-8047-7543"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Il Kim","raw_affiliation_strings":["BK21 PLUS Center for Advanced Chemical Technology Department of Polymer Science and Engineering Pusan National University  Busan 609\u2013735 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 PLUS Center for Advanced Chemical Technology Department of Polymer Science and Engineering Pusan National University  Busan 609\u2013735 Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020509355","https://openalex.org/A5082869373"],"corresponding_institution_ids":["https://openalex.org/I111277659","https://openalex.org/I4210148121","https://openalex.org/I4921948"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.8172,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.66423585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"5","issue":"15","first_page":"1874","last_page":"1883"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acid-degradable-polymers","display_name":"acid-degradable polymers","score":0.859000027179718},{"id":"https://openalex.org/keywords/intracellular-drug-delivery","display_name":"intracellular drug delivery","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.9800000190734863},{"id":"https://openalex.org/keywords/endosomal-escape","display_name":"endosomal escape","score":0.6129999756813049},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.7429999709129333},{"id":"https://openalex.org/keywords/blood-circulation","display_name":"blood circulation","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.7305118441581726},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6903165578842163},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.597536563873291},{"id":"https://openalex.org/C2779578285","wikidata":"https://www.wikidata.org/wiki/Q146322","display_name":"Polyurethane","level":2,"score":0.5079653859138489},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3784061670303345},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34604090452194214},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3447605073451996},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3246076703071594},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3216780424118042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22504085302352905},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.13295906782150269},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10444590449333191},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0865328311920166},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011140","descriptor_name":"Polyurethanes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011140","descriptor_name":"Polyurethanes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011140","descriptor_name":"Polyurethanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011140","descriptor_name":"Polyurethanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/adhm.201600126","doi":"https://doi.org/10.1002/adhm.201600126","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.201600126","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},{"id":"pmid:27245616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27245616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced healthcare materials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.75}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1962872293","https://openalex.org/W1967637067","https://openalex.org/W2011564453","https://openalex.org/W2012861715","https://openalex.org/W2015193936","https://openalex.org/W2031544819","https://openalex.org/W2032760352","https://openalex.org/W2033330903","https://openalex.org/W2043244984","https://openalex.org/W2048571562","https://openalex.org/W2054547205","https://openalex.org/W2073556065","https://openalex.org/W2091654157","https://openalex.org/W2095194582","https://openalex.org/W2101094141","https://openalex.org/W2106512307","https://openalex.org/W2114569084","https://openalex.org/W2130166533","https://openalex.org/W2132789515","https://openalex.org/W2134726513","https://openalex.org/W2138853132","https://openalex.org/W2141812295","https://openalex.org/W2167263245","https://openalex.org/W2172085761","https://openalex.org/W2279106522","https://openalex.org/W2314353462","https://openalex.org/W2314799819"],"related_works":["https://openalex.org/W2301029564","https://openalex.org/W2985741023","https://openalex.org/W2966411320","https://openalex.org/W4399444031","https://openalex.org/W4311692621","https://openalex.org/W2279106522","https://openalex.org/W2085647517","https://openalex.org/W4417292192","https://openalex.org/W2084909525","https://openalex.org/W2075634481"],"abstract_inverted_index":{"Nanoscale":[0],"drug":[1],"carriers":[2],"fabricated":[3],"by":[4],"phospholipid":[5],"end-capped":[6],"polyurethane":[7],"bearing":[8],"acetal":[9],"backbones":[10],"that":[11],"degrade":[12],"in":[13,31],"acidic":[14,32],"conditions":[15],"are":[16],"fabricated.":[17],"These":[18],"micelles":[19],"effectively":[20],"allow":[21],"drugs":[22],"to":[23],"enter":[24],"the":[25],"blood":[26],"circulation,":[27],"and":[28,34],"then":[29],"disintegrate":[30],"endosomes":[33],"lysosomes":[35],"for":[36],"intelligent":[37],"delivery":[38],"of":[39],"payloads.":[40]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}