{"id":"https://openalex.org/W2413635864","doi":"https://doi.org/10.1385/1-59745-168-1:107","title":"Surface-Modified Biodegradable Microspheres for DNA Vaccine Delivery","display_name":"Surface-Modified Biodegradable Microspheres for DNA Vaccine Delivery","publication_year":2006,"publication_date":"2006-09-20","ids":{"openalex":"https://openalex.org/W2413635864","doi":"https://doi.org/10.1385/1-59745-168-1:107","mag":"2413635864","pmid":"https://pubmed.ncbi.nlm.nih.gov/16988450"},"language":"en","primary_location":{"id":"doi:10.1385/1-59745-168-1:107","doi":"https://doi.org/10.1385/1-59745-168-1:107","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59745-168-1:107","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Vaccines","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4235204701","display_name":"DNA Vaccines"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049547317","display_name":"Mark E. Keegan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343143571","display_name":"Draper Laboratory","ror":"https://ror.org/04378d909","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343143571"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Keegan","raw_affiliation_strings":["The Charles Stark Draper Laboratory, Cambridge, MA, USA","The Charles Stark Draper Laboratory, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Charles Stark Draper Laboratory, Cambridge, MA, USA","institution_ids":["https://openalex.org/I1343143571"]},{"raw_affiliation_string":"The Charles Stark Draper Laboratory, Cambridge","institution_ids":["https://openalex.org/I1343143571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012106344","display_name":"W. Mark Saltzman","orcid":"https://orcid.org/0000-0002-2163-549X","observed_orcids":["https://orcid.org/0000-0002-2163-549X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Mark Saltzman","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.9655,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.97106109,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"127","issue":null,"first_page":"107","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.22550000250339508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-vaccine-delivery","display_name":"DNA vaccine delivery","score":0.871999979019165},{"id":"https://openalex.org/keywords/biodegradable-microspheres","display_name":"biodegradable microspheres","score":0.9829999804496765},{"id":"https://openalex.org/keywords/surface-modification","display_name":"surface modification","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cell-targeting","display_name":"cell targeting","score":0.5870000123977661},{"id":"https://openalex.org/keywords/dna-encapsulation","display_name":"DNA encapsulation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/biomaterials","display_name":"biomaterials","score":0.6420000195503235},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C189942447","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microsphere","level":2,"score":0.7447478771209717},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.6717519760131836},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6482989192008972},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6054052114486694},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.5177911520004272},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4607656002044678},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.43359076976776123},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4207441806793213},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.27567726373672485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14139476418495178},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09474751353263855},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09278342127799988},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1385/1-59745-168-1:107","doi":"https://doi.org/10.1385/1-59745-168-1:107","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59745-168-1:107","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Vaccines","raw_type":"book-chapter"},{"id":"pmid:16988450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16988450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1985882639","https://openalex.org/W2005246945","https://openalex.org/W2016542478","https://openalex.org/W2032896288","https://openalex.org/W2048408942","https://openalex.org/W2080492959","https://openalex.org/W2163245582","https://openalex.org/W3118526450"],"related_works":["https://openalex.org/W2090030504","https://openalex.org/W2053203848","https://openalex.org/W2048849036","https://openalex.org/W1998429819","https://openalex.org/W2004963209","https://openalex.org/W2004554125","https://openalex.org/W2093955338","https://openalex.org/W2098877646","https://openalex.org/W1460982979","https://openalex.org/W4248447532"],"abstract_inverted_index":{"Encapsulating":[0],"DNA":[1,18,48,119],"within":[2,120],"degradable":[3,88,121],"delivery":[4,89],"vehicles":[5,31,90],"such":[6],"as":[7,94],"micro-":[8],"or":[9],"nanospheres":[10],"provides":[11,39],"an":[12],"effective":[13],"way":[14,41],"to":[15,24,28,33,42,61,70,84,134],"protect":[16],"the":[17,20,34,44,59,62,73,76,85,95,135],"from":[19],"surrounding":[21],"environment":[22],"prior":[23],"delivery.":[25,49],"The":[26],"ability":[27],"target":[29],"these":[30,138],"directly":[32],"cell":[35,55,78],"type":[36],"of":[37,47,52,65,75,82,87,118,124,137],"interest":[38],"a":[40,125],"enhance":[43],"overall":[45],"efficiency":[46],"One":[50],"means":[51],"highly":[53],"specific":[54],"targeting":[56],"is":[57],"through":[58],"addition":[60],"vehicle":[63,99],"surface":[64,74,86,136],"ligands":[66,83,133],"that":[67],"bind":[68],"specifically":[69],"receptors":[71],"on":[72],"targeted":[77],"type.":[79],"Covalent":[80],"conjugation":[81],"can":[91],"be":[92],"difficult,":[93],"most":[96],"commonly":[97,126],"used":[98,127],"formulations":[100],"use":[101],"materials":[102],"selected":[103],"for":[104,113],"their":[105],"general":[106],"chemical":[107],"inertness.":[108],"This":[109],"chapter":[110],"describes":[111],"methods":[112],"overcoming":[114],"this,":[115],"enabling":[116],"encapsulation":[117],"microspheres":[122],"made":[123],"biomaterial":[128],"and":[129],"then":[130],"covalently":[131],"conjugating":[132],"microspheres.":[139]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}