{"id":"https://openalex.org/W2413629840","doi":null,"title":"Beta-cell crosstalk: a further dimension in the stimulus-secretion coupling of glucose-induced insulin release.","display_name":"Beta-cell crosstalk: a further dimension in the stimulus-secretion coupling of glucose-induced insulin release.","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W2413629840","mag":"2413629840","pmid":"https://pubmed.ncbi.nlm.nih.gov/12688633"},"language":"en","primary_location":{"id":"pmid:12688633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12688633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes & metabolism","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://archive-ouverte.unige.ch/unige:193081","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050440450","display_name":"David Caton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"D Caton","raw_affiliation_strings":["Department of Morphology, University of Geneva, Medical School, 1211 Geneva 4, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, University of Geneva, Medical School, 1211 Geneva 4, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Calabrese","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Calabrese","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025897377","display_name":"Christophe Mas","orcid":"https://orcid.org/0000-0002-7585-1091","observed_orcids":["https://orcid.org/0000-0002-7585-1091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Mas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077729576","display_name":"V\u00e9ronique Serre\u2010Beinier","orcid":"https://orcid.org/0000-0002-6016-1645","observed_orcids":["https://orcid.org/0000-0002-6016-1645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Serre-Beinier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023130040","display_name":"Ambroise Wonkam","orcid":"https://orcid.org/0000-0003-1420-9051","observed_orcids":["https://orcid.org/0000-0003-1420-9051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Wonkam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103515085","display_name":"Paolo Meda","orcid":"https://orcid.org/0000-0003-4380-5530","observed_orcids":["https://orcid.org/0000-0003-4380-5530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Meda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7828,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.75871422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"28","issue":"6 Pt 2","first_page":"3S45","last_page":"53; discussion 3S108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.20239999890327454,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/connexin-36","display_name":"connexin 36","score":0.9160000085830688},{"id":"https://openalex.org/keywords/gap-junctions","display_name":"gap junctions","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cell-cell-coupling","display_name":"cell coupling","score":0.718999981880188},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.9020000100135803},{"id":"https://openalex.org/keywords/stimulus-secretion-coupling","display_name":"stimulus-secretion coupling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.953000009059906},{"id":"https://openalex.org/keywords/beta-cell-growth","display_name":"beta-cell growth","score":0.6439999938011169},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8799999952316284},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/beta-cell-replacement-therapy","display_name":"beta cell replacement therapy","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2780228694","wikidata":"https://www.wikidata.org/wiki/Q423489","display_name":"Connexin","level":4,"score":0.8518344163894653},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.7359473705291748},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.6973869800567627},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.6514341235160828},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.6302778720855713},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5958935618400574},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5432802438735962},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5265132188796997},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.47758200764656067},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4584367871284485},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.45154285430908203},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43451589345932007},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4297754764556885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38572871685028076},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.3629438579082489},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36085760593414307},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3584388196468353},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.35254305601119995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16429466009140015},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.15325140953063965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13840124011039734},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0811028778553009},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097004","descriptor_name":"Gap Junction delta-2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12688633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12688633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes & metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:aou:unige:193081","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:193081","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes & metabolism, vol. 28, no. 6 Pt 2 (2002) p. 3S45-3S53","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2413629840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12688633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:unige.ch:aou:unige:193081","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:193081","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes & metabolism, vol. 28, no. 6 Pt 2 (2002) p. 3S45-3S53","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1988021631","https://openalex.org/W2040746568","https://openalex.org/W2100571538","https://openalex.org/W2064528021","https://openalex.org/W2259401621","https://openalex.org/W2030294790","https://openalex.org/W2108896758","https://openalex.org/W1982324050","https://openalex.org/W2076448822","https://openalex.org/W2136203270"],"abstract_inverted_index":{"Pancreatic":[0],"beta-cells":[1,20],"are":[2,21,40,188,204],"connected":[3],"by":[4],"gap":[5],"junction":[6],"channels":[7],"made":[8],"of":[9,46,75,105,110,134,142,147,162,170,185,195,210],"a":[10,71,98,160,190,211],"connexin":[11,123,163],"protein,":[12],"referred":[13],"to":[14,23,55,157,167,181],"as":[15,80,82,115],"Cx36.":[16],"Through":[17],"these":[18,38],"channels,":[19],"coupled":[22],"each":[24],"other,":[25],"i.e.":[26],"exchange":[27],"cytoplasmic":[28],"ions":[29],"and":[30,64,89,198],"small":[31],"metabolites.":[32],"Previous":[33],"experiments":[34,86],"have":[35],"indicated":[36],"that":[37,93],"exchanges":[39],"important":[41],"for":[42,70,192,206],"coordinating":[43],"the":[44,102,118,132,139,154,168,183,193,207],"function":[45],"individual":[47],"cells":[48,197],"within":[49,149],"pancreatic":[50,151],"islets,":[51,152],"particularly":[52],"with":[53],"regard":[54],"glucose-induced":[56],"insulin":[57,106],"secretion.":[58],"Advances":[59],"in":[60,78,83,87,101,138,173,215],"molecular":[61],"biology,":[62],"genetics":[63],"mouse":[65],"transgenic":[66],"approaches":[67],"allow":[68],"now":[69],"direct":[72,135],"experimental":[73],"testing":[74],"this":[76,126],"mechanism":[77,121],"vitro":[79],"well":[81],"vivo.":[84],"Recent":[85],"rodent":[88],"culture":[90],"models":[91],"suggest":[92],"connexin-dependent":[94],"cell-to-cell":[95,136],"crosstalk":[96],"is":[97],"significant":[99],"player":[100],"multifactorial":[103],"regulation":[104,141],"secretion":[107],"and,":[108],"possibly,":[109],"other":[111],"beta-cell":[112,143,171,186],"functions,":[113],"such":[114],"growth.":[116],"Elucidating":[117],"still":[119],"obscure":[120],"whereby":[122],"signalling":[124],"exerts":[125],"influence":[127],"will":[128],"provide":[129],"insights":[130],"on":[131],"contribution":[133],"interactions":[137],"physiological":[140],"life.":[144],"The":[145],"presence":[146],"Cx36":[148],"human":[150],"raises":[153],"further":[155],"challenge":[156],"determine":[158],"whether":[159],"dysfunction":[161],"signaling":[164],"may":[165],"contribute":[166],"pathophysiology":[169],"dysfunctions":[172],"type":[174,177],"I":[175],"and/or":[176],"II":[178],"diabetes.":[179],"Efforts":[180],"understand":[182],"functions":[184],"connexins":[187],"also":[189],"prerequisite":[191],"engineering":[194],"surrogate":[196],"their":[199],"proper":[200],"tridimensional":[201],"packaging,":[202],"which":[203],"instrumental":[205],"future":[208],"implementation":[209],"replacement":[212],"cell":[213],"therapy":[214],"diabetic":[216],"patients.":[217]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}