{"id":"https://openalex.org/W2413624385","doi":null,"title":"Oxytocin and carbetocin effects on spontaneous behavior of male rats: modulation by oxytocin receptor antagonists.","display_name":"Oxytocin and carbetocin effects on spontaneous behavior of male rats: modulation by oxytocin receptor antagonists.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2413624385","mag":"2413624385","pmid":"https://pubmed.ncbi.nlm.nih.gov/19855356"},"language":"en","primary_location":{"id":"pmid:19855356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19855356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072471944","display_name":"V\u011bra Klenerov\u00e1","orcid":"https://orcid.org/0000-0002-8885-7150","observed_orcids":["https://orcid.org/0000-0002-8885-7150"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Vera Klenerova","raw_affiliation_strings":["Laboratory of Biochemical Neuropharmacology, Institute of Medical Biochemistry, 1st Faculty of Medicine, Charles University in Prague, Czech Republic. vera.klenerova@LF1.cuni.cz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemical Neuropharmacology, Institute of Medical Biochemistry, 1st Faculty of Medicine, Charles University in Prague, Czech Republic. vera.klenerova@LF1.cuni.cz","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047545360","display_name":"Ivan Krej\u010d\u0131\u0301","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivan Krejci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051319203","display_name":"Pavel \u0160\u0131\u0301da","orcid":"https://orcid.org/0000-0002-5788-1545","observed_orcids":["https://orcid.org/0000-0002-5788-1545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pavel Sida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054001423","display_name":"Zdenek Hlinak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zdenek Hlinak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071168525","display_name":"S. Hynie","orcid":"https://orcid.org/0000-0002-3613-9034","observed_orcids":["https://orcid.org/0000-0002-3613-9034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sixtus Hynie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5524,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.64418701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"3","first_page":"335","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":1.0},{"id":"https://openalex.org/keywords/carbetocin","display_name":"carbetocin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxytocin-receptor-antagonist","display_name":"oxytocin receptor antagonist","score":0.9819999933242798},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.7319999933242798},{"id":"https://openalex.org/keywords/locomotion","display_name":"locomotion","score":0.5820000171661377},{"id":"https://openalex.org/keywords/grooming","display_name":"grooming","score":0.5350000262260437},{"id":"https://openalex.org/keywords/rearing-behavior","display_name":"rearing behavior","score":0.718999981880188},{"id":"https://openalex.org/keywords/exploration","display_name":"exploration","score":0.5479999780654907},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.8180000185966492},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.8579999804496765},{"id":"https://openalex.org/keywords/male-rats","display_name":"male rats","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.7591354250907898},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.6710290312767029},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6323952674865723},{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.6014248728752136},{"id":"https://openalex.org/C173586616","wikidata":"https://www.wikidata.org/wiki/Q5359685","display_name":"Elevated plus maze","level":3,"score":0.5197160243988037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5011773109436035},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49682191014289856},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4902975857257843},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.4495748281478882},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43303507566452026},{"id":"https://openalex.org/C181612422","wikidata":"https://www.wikidata.org/wiki/Q14908140","display_name":"Oxytocin receptor","level":3,"score":0.4168859124183655},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33440154790878296},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3167470693588257},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001892","descriptor_name":"Camphanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006120","descriptor_name":"Grooming","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006727","descriptor_name":"Hormone Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010120","descriptor_name":"Oxytocics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012149","descriptor_name":"Restraint, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014668","descriptor_name":"Vasotocin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014668","descriptor_name":"Vasotocin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018045","descriptor_name":"Receptors, Oxytocin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19855356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19855356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},{"id":"mag:2413624385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19855356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W257686428","https://openalex.org/W2417884577","https://openalex.org/W2593326869","https://openalex.org/W2088498149","https://openalex.org/W2093922373","https://openalex.org/W4416439348","https://openalex.org/W2293280674","https://openalex.org/W1728250617","https://openalex.org/W2077621719","https://openalex.org/W3209273604"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Oxytocin":[1],"(OXY)":[2],"in":[3,26,40,87,116,127,161,177,189,279,297,302,308],"addition":[4],"to":[5,284],"peripheral":[6],"actions":[7,30],"has":[8],"many":[9],"central":[10],"regulatory":[11],"functions":[12],"which":[13,28],"can":[14,43],"be":[15,44],"studied":[16],"on":[17,52,70],"animal":[18],"models.":[19],"In":[20],"the":[21,41,53,65,117,143,162,190,194,205,215,231,309],"present":[22],"study":[23],"we":[24,77],"examined":[25],"rats,":[27],"behavioral":[29,54,75,191],"of":[31,36,58,67,111,125,193,207,214,233,240,261,281],"OXY":[32,37,68,71,84,90,98,141,202,219,228,241,247,262,282,292],"and":[33,72,81,103,107,158,220,263,287],"long-acting":[34],"carba-analog":[35],"carbetocin":[38],"(CBT)":[39],"open-field":[42,119],"inhibited":[45],"by":[46,201,218,227,236,254,291],"OXY-receptor":[47],"antagonists.":[48,229,257],"Our":[49],"interest":[50],"focused":[51],"patterns":[55],"considered":[56],"indicative":[57],"anxiety-related":[59],"behavior.":[60],"To":[61],"determine":[62],"what":[63],"is":[64],"participation":[66],"receptor":[69,305],"CBT":[73,94,160,221],"induced":[74,200,217,235,248,290],"changes,":[76],"used":[78,256],"two":[79,195],"peptide":[80],"one":[82],"nonpeptide":[83],"antagonists":[85,99,265,283],"differing":[86],"selectivity":[88],"for":[89,183],"receptor.":[91],"METHODS:":[92],"OXY,":[93],"as":[95,97],"well":[96],"were":[100],"injected":[101],"intraperitoneally,":[102],"spontaneous":[104],"behavior":[105],"(horizontal":[106],"vertical":[108],"activity,":[109],"grooming)":[110],"Wistar":[112],"rats":[113],"was":[114,131,197,225,242,251],"observed":[115],"circular":[118],"arena":[120],"60":[121],"min":[122],"after":[123,137,179,210,266],"application":[124,269],"drugs;":[126],"some":[128],"experiments":[129],"testing":[130],"performed":[132],"without":[133],"treatment":[134],"few":[135],"days":[136],"drug":[138],"administration.":[139],"RESULTS:":[140],"at":[142],"dose":[144,163,239],"0.05":[145],"mg/kg":[146,154,166],"increased":[147,172],"locomotion":[148,157],"indicating":[149,222],"anxiety":[150],"attenuation,":[151],"but":[152],"1.0":[153,237],"reduced":[155],"both":[156,180],"rearing.":[159],"range":[164],"0.1-3.0":[165],"either":[167],"did":[168],"not":[169],"change":[170],"or":[171],"horizontal":[173],"activity.":[174],"The":[175,212,246,277],"increase":[176,213],"exploration":[178,234],"peptides":[181,196],"persisted":[182],"several":[184],"days.":[185],"A":[186],"marked":[187],"difference":[188],"effects":[192,260],"grooming":[198,250,286],"enhancement":[199],"compared":[203],"with":[204],"absence":[206],"this":[208],"effect":[209],"CBT.":[211],"activity":[216],"anxiolytic-like":[223],"action":[224],"blocked":[226],"However,":[230],"reduction":[232],"mg":[238],"only":[243],"partially":[244],"reversed.":[245],"enhanced":[249],"completely":[252],"antagonized":[253],"all":[255],"CONCLUSIONS:":[258],"Behavioral":[259],"its":[264],"their":[267],"i.p.":[268],"indicate":[270],"that":[271,294],"they":[272],"penetrate":[273],"blood":[274],"brain":[275,303],"barrier.":[276],"diversity":[278],"potency":[280],"inhibit":[285],"other":[288],"behaviors":[289,299],"suggests":[293],"receptors":[295],"participating":[296],"these":[298],"may":[300],"differ":[301],"localization,":[304],"conformation":[306],"and/or":[307],"utilized":[310],"signaling":[311],"pathways.":[312]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
