{"id":"https://openalex.org/W2413622929","doi":null,"title":"Incidence and epidemiological factors of hepatocellular carcinoma in Valencia during the year 2000.","display_name":"Incidence and epidemiological factors of hepatocellular carcinoma in Valencia during the year 2000.","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W2413622929","mag":"2413622929","pmid":"https://pubmed.ncbi.nlm.nih.gov/12852777"},"language":"en","primary_location":{"id":"pmid:12852777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12852777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de enfermedades digestivas","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109174120","display_name":"M. L. Garc\u00eda-Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M L Garc\u00eda-Torres","raw_affiliation_strings":["Servicio de Hepatolog\u00eda. Hospital Cl\u00edinco Universitario. Facultad de Medicina. Valecia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Hepatolog\u00eda. Hospital Cl\u00edinco Universitario. Facultad de Medicina. Valecia, Spain","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112936609","display_name":"A Zaragoz\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Zaragoz\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037202492","display_name":"Remedios Giner\u2010Dur\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Giner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025019704","display_name":"J Primo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Primo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042129764","display_name":"J A del Olmo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A del Olmo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4089,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.83716973,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"95","issue":"6","first_page":"385","last_page":"8, 381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/incidence","display_name":"incidence","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.8420000076293945},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/child-pugh-score","display_name":"Child-Pugh score","score":0.8220000267028809},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.8659999966621399},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.5680000185966492},{"id":"https://openalex.org/keywords/valencia-province","display_name":"Valencia province","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.9342260360717773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9020392894744873},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7157570123672485},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.7046256065368652},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.6907662749290466},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6017887592315674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5166502594947815},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.43469518423080444},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.4304758310317993},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.42853209376335144},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.4246240258216858},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.19695380330085754},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.1283596158027649},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008104","descriptor_name":"Liver Cirrhosis, Alcoholic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12852777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12852777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de enfermedades digestivas","raw_type":"Journal Article"},{"id":"mag:2413622929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12852777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4252936876","https://openalex.org/W7216512012","https://openalex.org/W4392728854","https://openalex.org/W2977263339","https://openalex.org/W2419536771","https://openalex.org/W3007890852","https://openalex.org/W1982770627","https://openalex.org/W2320780982","https://openalex.org/W4398228958","https://openalex.org/W4220657924"],"abstract_inverted_index":{"AIM:":[0],"to":[1,76,152],"ascertain":[2],"the":[3,12,27,105,108,110,115,120,133,144,153,172,196,204],"incidence":[4],"and":[5,54,72,119,146],"epidemiological":[6],"factors":[7],"of":[8,14,23,43,46,58,62,82,100,107,132,143,175,198],"hepatocellular":[9,24,47,176],"carcinoma":[10,25,48,177],"in":[11,78,98,114,130,141,178,193],"Province":[13],"Valencia,":[15],"Spain.":[16],"DESIGN:":[17],"a":[18,41,50,55,148],"prospective":[19],"study":[20],"was":[21,68,74,96,125,169,183,203],"made":[22],"during":[26,37,181],"year":[28],"2000":[29,182],"collecting":[30],"all":[31],"diagnosed":[32],"cases":[33,45,109],"from":[34],"four":[35],"hospitals":[36],"that":[38],"year.":[39],"RESULTS:":[40],"total":[42],"64":[44],"with":[49,161],"male":[51],"predominance":[52],"(42/22)":[53],"mean":[56],"age":[57],"73.4":[59],"years":[60],"(range":[61],"42-90)":[63],"were":[64,84,112],"diagnosed.":[65],"Incidence":[66],"rate":[67,174],"8.2":[69,184],"per":[70,185],"100,000,":[71],"cirrhosis":[73],"known":[75],"pre-exist":[77],"most":[79],"cases,":[80],"half":[81],"which":[83],"Child-Pugh":[85,167,218],"A.":[86],"Anti-VHC":[87],"positive,":[88],"alone":[89],"or":[90,92,166],"alcohol":[91],"virus":[93,202],"B":[94],"related":[95],"detected":[97],"3":[99,128],"every":[101],"4":[102],"cases.":[103,134],"In":[104],"majority":[106],"tumours":[111],"located":[113],"right":[116],"hepatic":[117],"lobe":[118],"size":[121,150],"at":[122],"first":[123],"diagnosis":[124],"less":[126],"than":[127],"cm":[129],"37.3%":[131,142],"Alpha-fetoprotein":[135],"levels":[136],"only":[137],"exceeded":[138],"200":[139],"mg/ml":[140],"patients":[145],"bore":[147],"good":[149],"relation":[151,158],"tumour":[154,164],"(R=0.245,":[155],"p=0.003.":[156],"No":[157],"vis-\u00e0-vis":[159],"aetiology":[160],"age,":[162],"sex,":[163],"location":[165],"stage":[168],"found.":[170,208],"CONCLUSIONS:":[171],"incident":[173],"Valencia":[179],"province":[180],"100,000":[186],"individuals.":[187],"This":[188],"lesion":[189],"appeared":[190],"more":[191],"frequently":[192],"men":[194],"between":[195],"ages":[197],"60-80.":[199],"Hepatitis":[200,214],"C":[201,215],"main":[205],"etiologic":[206],"agent":[207],"Key":[209],"words:":[210],"Hepatocellular":[211],"carcinoma.":[212],"Incidence.":[213],"virus.":[216],"Epidemiology.":[217],"grade.":[219],"Alpha-fetoprotein.":[220]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}