{"id":"https://openalex.org/W2413617284","doi":"https://doi.org/10.1016/s0022-5347(17)32821-5","title":"Flow Cytometric Bromodeoxyuridine/Deoxyribonucleic Acid Bivariate Analysis for Predicting Tumor Invasiveness of Upper Tract Urothelial Cancer","display_name":"Flow Cytometric Bromodeoxyuridine/Deoxyribonucleic Acid Bivariate Analysis for Predicting Tumor Invasiveness of Upper Tract Urothelial Cancer","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W2413617284","doi":"https://doi.org/10.1016/s0022-5347(17)32821-5","mag":"2413617284","pmid":"https://pubmed.ncbi.nlm.nih.gov/8201694"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(17)32821-5","doi":"https://doi.org/10.1016/s0022-5347(17)32821-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)32821-5","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020251887","display_name":"Ayako Miyakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayako Miyakawa","raw_affiliation_strings":["From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071174564","display_name":"Masaaki Tachibana","orcid":"https://orcid.org/0000-0002-0947-6772","observed_orcids":["https://orcid.org/0000-0002-0947-6772"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Tachibana","raw_affiliation_strings":["From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111751120","display_name":"Jun Nakashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Nakashima","raw_affiliation_strings":["From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113664084","display_name":"Nobuhiro Deguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiro Deguchi","raw_affiliation_strings":["From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089388893","display_name":"Shiro Baba","orcid":"https://orcid.org/0000-0002-4170-1802","observed_orcids":["https://orcid.org/0000-0002-4170-1802"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shiro Baba","raw_affiliation_strings":["From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100975791","display_name":"Hiroshi Tazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Tazaki","raw_affiliation_strings":["From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":3.653,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.92081959,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"152","issue":"1","first_page":"76","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/upper-tract-urothelial-carcinoma","display_name":"upper tract urothelial carcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6769999861717224},{"id":"https://openalex.org/keywords/bromodeoxyuridine-labeling-index","display_name":"bromodeoxyuridine labeling index","score":0.8600000143051147},{"id":"https://openalex.org/keywords/dna-ploidy","display_name":"DNA ploidy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7820000052452087},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.4729999899864197},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.5989999771118164},{"id":"https://openalex.org/keywords/nephroureterectomy","display_name":"nephroureterectomy","score":0.8970000147819519},{"id":"https://openalex.org/keywords/dna-aneuploidy","display_name":"DNA aneuploidy","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C2778260397","wikidata":"https://www.wikidata.org/wiki/Q419861","display_name":"Bromodeoxyuridine","level":3,"score":0.9185429811477661},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4760584533214569},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47204291820526123},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4453125596046448},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3490966260433197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3426050543785095},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3369631767272949},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2698110044002533},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.19356712698936462}],"mesh":[{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011003","descriptor_name":"Ploidies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014513","descriptor_name":"Ureter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014516","descriptor_name":"Ureteral Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014516","descriptor_name":"Ureteral Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D014516","descriptor_name":"Ureteral Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5347(17)32821-5","doi":"https://doi.org/10.1016/s0022-5347(17)32821-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)32821-5","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:8201694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8201694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W79144475","https://openalex.org/W204107972","https://openalex.org/W1580788756","https://openalex.org/W1594148294","https://openalex.org/W2031468048","https://openalex.org/W2093308293","https://openalex.org/W2112449242","https://openalex.org/W2150067782","https://openalex.org/W2307377078","https://openalex.org/W2402598049","https://openalex.org/W2414650387","https://openalex.org/W2415790829","https://openalex.org/W2420271570","https://openalex.org/W2724375271","https://openalex.org/W2992994858","https://openalex.org/W3147894994","https://openalex.org/W4249475954"],"related_works":["https://openalex.org/W2420271570","https://openalex.org/W2441983351","https://openalex.org/W2307377078","https://openalex.org/W2408915317","https://openalex.org/W2400937009","https://openalex.org/W2080172815","https://openalex.org/W2413562734","https://openalex.org/W2185464693","https://openalex.org/W2414650387","https://openalex.org/W2472489708"],"abstract_inverted_index":{"We":[0],"previously":[1],"reported":[2],"that":[3,60,223],"flow":[4,224],"cytometric":[5,68,225],"bromodeoxyuridine/deoxyribonucleic":[6],"acid":[7],"(DNA)":[8],"bivariate":[9,38,227],"analysis":[10,39,128,228],"can":[11,40],"provide":[12,41],"important":[13,149,157],"information":[14,44],"on":[15,45],"the":[16,24,102,130,139,146,159,190],"malignant":[17],"potential":[18],"of":[19,54,211],"bladder":[20],"cancer.":[21],"Therefore,":[22],"in":[23,78,195,209,232],"current":[25],"study":[26],"we":[27],"further":[28],"evaluated":[29],"upper":[30,48,56,238],"tract":[31,49,57,239],"urothelial":[32,50,58,240],"tumors":[33,59,85,109,198],"to":[34,95,117,137,162,189],"clarify":[35],"whether":[36],"DNA/bromodeoxyuridine":[37],"additional":[42],"prognostic":[43],"patients":[46,234],"with":[47,88,121,145,235],"tumor.":[51],"A":[52],"total":[53],"43":[55],"were":[61,74,86,199,207],"resected":[62],"by":[63,76,169],"nephroureterectomy":[64],"was":[65,135,165],"analyzed.":[66],"Flow":[67],"DNA":[69,83,98,174],"ploidy":[70,175],"and":[71,158,202,213],"bromodeoxyuridine":[72,80,107,123,170,191,215],"labeling":[73,81,171,192,216],"determined":[75],"an":[77,89],"vitro":[79],"method.":[82],"diploid":[84],"associated":[87],"85.9%":[90],"3-year":[91,113,185,204],"survival":[92,114,127,186,205],"rate":[93,115],"compared":[94,116],"36.5%":[96],"for":[97,119,143],"aneuploid":[99],"tumors.":[100,125],"On":[101],"other":[103],"hand,":[104],"11":[105],"high":[106,214],"labeled":[108,124],"demonstrated":[110],"a":[111],"16.4%":[112],"82.4%":[118],"those":[120],"low":[122,212],"Multivariate":[126],"using":[129],"Cox":[131],"proportional":[132],"regression":[133],"model":[134],"performed":[136],"identify":[138],"most":[140,148],"informative":[141],"factors":[142],"prognosis,":[144],"single":[147],"factor":[150,161],"being":[151],"histological":[152],"tumor":[153,166],"stage.":[154],"Nearly":[155],"as":[156],"next":[160],"be":[163,230],"chosen":[164],"grade,":[167],"followed":[168],"index":[172,193,217],"status.":[173],"status":[176,194],"did":[177],"not":[178],"influence":[179],"clinical":[180],"outcome.":[181],"Thereafter,":[182],"when":[183],"actuarial":[184],"rates":[187,206],"according":[188],"grade":[196,236],"3":[197,237],"estimated,":[200],"68.4%":[201],"16.7%":[203],"observed":[208],"cases":[210],"tumors,":[218],"respectively.":[219],"These":[220],"results":[221],"indicate":[222],"bromodeoxyuridine/DNA":[226],"may":[229],"useful":[231],"dividing":[233],"carcinoma":[241],"into":[242],"2":[243],"different":[244],"prognosis":[245],"groups.":[246]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
