{"id":"https://openalex.org/W2413616643","doi":null,"title":"Hypoglycaemic valleys: an under-recognised problem in type 2 diabetes?","display_name":"Hypoglycaemic valleys: an under-recognised problem in type 2 diabetes?","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2413616643","mag":"2413616643","pmid":"https://pubmed.ncbi.nlm.nih.gov/12166599"},"language":"en","primary_location":{"id":"pmid:12166599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12166599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical practice. Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010285104","display_name":"Brian M. Frier","orcid":"https://orcid.org/0000-0002-9590-9473","observed_orcids":["https://orcid.org/0000-0002-9590-9473"]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Brian M Frier","raw_affiliation_strings":["Department of Diabetes, Royal Infirmary of Edinburgh, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes, Royal Infirmary of Edinburgh, Scotland, UK","institution_ids":["https://openalex.org/I2802789809"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010285104"],"corresponding_institution_ids":["https://openalex.org/I2802789809"],"apc_list":null,"apc_paid":null,"fwci":0.4697,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.69875346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":"129","first_page":"12","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.9459999799728394},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.9229999780654907},{"id":"https://openalex.org/keywords/oral-antidiabetic-drugs","display_name":"oral antidiabetic drugs","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pancreatic-beta-cell-failure","display_name":"pancreatic beta-cell failure","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hypoglycemia-awareness","display_name":"hypoglycemia awareness","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8645715713500977},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7991461753845215},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.720138669013977},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6880155801773071},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.6336020231246948},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.585654616355896},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5736469030380249},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.5426334738731384},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49175670742988586},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3559989929199219}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013453","descriptor_name":"Sulfonylurea Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12166599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12166599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical practice. Supplement","raw_type":"Journal Article"},{"id":"mag:2413616643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12166599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2150540429","https://openalex.org/W2921717212","https://openalex.org/W2100442612","https://openalex.org/W2057914440","https://openalex.org/W2056996684","https://openalex.org/W2888382225","https://openalex.org/W2156516527","https://openalex.org/W2808839099","https://openalex.org/W2097452925","https://openalex.org/W1999804954"],"abstract_inverted_index":{"In":[0,58,132],"the":[1,40,51,68,140],"treatment":[2],"of":[3,139,142,152,185,189,213,222],"type":[4,59,85,120,134,195,208],"2":[5,60,121,135,196],"diabetes,":[6,61,122,190],"mild":[7,160],"(self-treated)":[8],"hypoglycaemia":[9,27,48,112,129,143,161,223],"is":[10,21,31,105,113,130,224],"associated":[11],"with":[12,18,79,84,107,182,194,198,207],"some":[13],"oral":[14],"hypoglycaemic":[15],"agents":[16],"and":[17,44,49,67,97,165,180,191],"insulin,":[19],"but":[20,148,219],"perceived":[22],"to":[23,33,47,115,146,154,167],"be":[24,34,116,126,177],"uncommon;":[25],"severe":[26,128,170],"(requiring":[28],"external":[29],"help)":[30],"thought":[32],"rare.":[35,131],"Ageing":[36],"per":[37],"se":[38],"modifies":[39],"counterregulatory":[41,214],"(CR)":[42],"hormonal":[43,64,94,215],"symptomatic":[45,111],"responses":[46],"alters":[50],"glycaemic":[52,69,98,103],"thresholds":[53,70,99],"at":[54,73],"which":[55],"these":[56],"occur.":[57],"subtle":[62],"CR":[63,93],"deficiencies":[65,95],"occur,":[66],"are":[71,100,144],"set":[72],"higher":[74],"blood":[75],"glucose":[76],"levels":[77],"compared":[78],"non-diabetic":[80],"subjects":[81],"or":[82],"people":[83],"1":[86,209],"diabetes.":[87,210],"When":[88],"significant":[89],"insulin":[90,108,186],"deficiency":[91,216],"occurs,":[92],"appear,":[96],"modified":[101],"when":[102],"control":[104],"improved":[106],"therapy.":[109],"Although":[110],"reported":[114],"uncommon":[117],"in":[118,162],"sulphonylurea-treated":[119],"its":[123],"frequency":[124,141],"may":[125,176,217],"underestimated;":[127],"insulin-treated":[133],"diabetes":[136,197],"accurate":[137],"data":[138],"difficult":[145],"obtain,":[147],"an":[149],"annual":[150],"prevalence":[151],"30":[153],"40%":[155],"has":[156],"been":[157],"recorded":[158],"for":[159,169],"clinical":[163],"trials":[164],"0.5":[166],"2.3%":[168],"hypoglycaemia.":[171],"The":[172,211],"true":[173],"overall":[174],"frequencies":[175],"much":[178],"higher,":[179],"rise":[181],"increasing":[183],"duration":[184,188],"therapy,":[187],"age.":[192],"Patients":[193],"progressive":[199],"pancreatic":[200],"beta":[201],"cell":[202],"failure":[203],"increasingly":[204],"resemble":[205],"those":[206],"syndrome":[212],"develop,":[218],"impaired":[220],"awareness":[221],"uncommon.":[225]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}