{"id":"https://openalex.org/W2413614995","doi":null,"title":"Metformin inhibits cell growth by upregulating microRNA-26a in renal cancer cells.","display_name":"Metformin inhibits cell growth by upregulating microRNA-26a in renal cancer cells.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2413614995","mag":"2413614995","pmid":"https://pubmed.ncbi.nlm.nih.gov/25419360","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238495"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4238495","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238495","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238495","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101810451","display_name":"Feng\u2010Qiang Yang","orcid":"https://orcid.org/0000-0002-0650-5208","observed_orcids":["https://orcid.org/0000-0002-0650-5208"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng-Qiang Yang","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057466258","display_name":"Jijiao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-Jiao Wang","raw_affiliation_strings":["Department of Endocrinology, The Second Hospital Affiliated to Dalian Medical University Dalian, 116027, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The Second Hospital Affiliated to Dalian Medical University Dalian, 116027, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030545452","display_name":"Jiasheng Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-Sheng Yan","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101586847","display_name":"Jianhua Huang","orcid":"https://orcid.org/0000-0002-6923-007X","observed_orcids":["https://orcid.org/0000-0002-6923-007X"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Hua Huang","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100774472","display_name":"Wei Li","orcid":"https://orcid.org/0000-0001-6728-1300","observed_orcids":["https://orcid.org/0000-0001-6728-1300","https://orcid.org/0009-0008-8660-4580","https://orcid.org/0000-0002-4921-3766"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109304916","display_name":"Jian\u2010Ping Che","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Ping Che","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005878751","display_name":"Guangchun Wang","orcid":"https://orcid.org/0000-0002-0873-9163","observed_orcids":["https://orcid.org/0000-0002-0873-9163"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang-Chun Wang","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674204","display_name":"Min Liu","orcid":"https://orcid.org/0000-0002-6385-8077","observed_orcids":["https://orcid.org/0000-0002-6385-8077","https://orcid.org/0009-0004-6297-5855"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Liu","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100621094","display_name":"Junhua Zheng","orcid":"https://orcid.org/0000-0001-8492-3141","observed_orcids":["https://orcid.org/0000-0001-8492-3141"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Hua Zheng","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1016,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.76038775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"10","first_page":"3289","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/microrna-26a","display_name":"microRNA-26a","score":0.9269999861717224},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/786-o-cells","display_name":"786-O cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":1.0},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.7200000286102295},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4189999997615814},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.9255485534667969},{"id":"https://openalex.org/C2777688063","wikidata":"https://www.wikidata.org/wiki/Q142880","display_name":"Biguanide","level":4,"score":0.9044475555419922},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8071241974830627},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.774999737739563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7340586185455322},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.618000864982605},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6157793998718262},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5843330025672913},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5808912515640259},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5448340177536011},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5169257521629333},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4684318006038666},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.45630118250846863},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4314314126968384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31793999671936035},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2459283471107483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17306247353553772},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.08346804976463318},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07185155153274536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04985329508781433}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4238495","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238495","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"pmid:25419360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25419360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"mag:2413614995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25419360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4238495","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238495","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1980920427","https://openalex.org/W1984860479","https://openalex.org/W1986266236","https://openalex.org/W1986630370","https://openalex.org/W1990130829","https://openalex.org/W2001244850","https://openalex.org/W2010238890","https://openalex.org/W2014285846","https://openalex.org/W2025504334","https://openalex.org/W2054030645","https://openalex.org/W2067804603","https://openalex.org/W2070578980","https://openalex.org/W2072993593","https://openalex.org/W2085331940","https://openalex.org/W2088122814","https://openalex.org/W2097758673","https://openalex.org/W2111160461","https://openalex.org/W2123014930","https://openalex.org/W2152561870","https://openalex.org/W2160102037","https://openalex.org/W2161817637","https://openalex.org/W2164317031","https://openalex.org/W2166304083","https://openalex.org/W2911611736"],"related_works":["https://openalex.org/W2565733578","https://openalex.org/W2041118914","https://openalex.org/W2372763622","https://openalex.org/W2217427523","https://openalex.org/W2034687315","https://openalex.org/W2578948608","https://openalex.org/W2910899834","https://openalex.org/W2491251888","https://openalex.org/W2189632001","https://openalex.org/W2104314648"],"abstract_inverted_index":{"Accumulating":[0],"evidence":[1,142],"suggests":[2],"that":[3,146],"metformin,":[4],"a":[5,96,144],"biguanide":[6],"class":[7],"of":[8,49,76,87,100,118,150,156],"anti-diabetic":[9],"drugs,":[10],"possesses":[11],"anti-cancer":[12],"properties":[13],"and":[14,19,42,53,74,102,107,129,158],"may":[15],"reduce":[16],"cancer":[17,33,56,67],"risk":[18],"improve":[20],"prognosis.":[21],"However,":[22],"the":[23,59,72,137,147],"mechanism":[24,145],"by":[25,84,124],"which":[26],"metformin":[27,151],"affects":[28],"various":[29],"cancers,":[30],"including":[31],"renal":[32,66],"still":[34],"unknown.":[35],"MiR-26a":[36],"induces":[37],"cell":[38,40,43,68,122],"growth,":[39],"cycle":[41],"apoptosis":[44],"progression":[45],"via":[46],"direct":[47],"targeting":[48],"Bcl-2,":[50,126],"clyclin":[51],"D1":[52,104,128],"PTEN":[54,108,131],"in":[55,89,111],"cells.":[57],"In":[58],"present":[60],"study,":[61],"we":[62],"used":[63],"786-O":[64,90],"human":[65],"lines":[69],"to":[70,114,154],"study":[71],"effects":[73],"mechanisms":[75],"metformin.":[77,115],"Metformin":[78],"treatment":[79],"inhibited":[80,121],"RCC":[81],"cells":[82,91,112],"proliferation":[83,123],"increasing":[85],"expression":[86],"miR-26a":[88,119,157],"(P":[92],"<":[93],"0.05).":[94],"As":[95],"result,":[97],"protein":[98],"abundance":[99],"Bcl-2":[101],"cyclin":[103,127],"was":[105,109],"decreased":[106],"increased":[110],"exposed":[113],"Also":[116],"over-expression":[117],"can":[120],"down-regulating":[125],"up-regulating":[130],"expression.":[132],"Therefore,":[133],"these":[134],"data":[135],"for":[136,143],"first":[138],"time":[139],"provide":[140],"novel":[141],"anticancer":[148],"activities":[149],"are":[152],"due":[153],"upregulation":[155],"affect":[159],"its":[160],"downstream":[161],"target":[162],"gene.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
