{"id":"https://openalex.org/W2413530375","doi":"https://doi.org/10.1016/j.humimm.2016.04.020","title":"Enhancing NK cell cytotoxicity by miR-182 in hepatocellular carcinoma","display_name":"Enhancing NK cell cytotoxicity by miR-182 in hepatocellular carcinoma","publication_year":2016,"publication_date":"2016-06-02","ids":{"openalex":"https://openalex.org/W2413530375","doi":"https://doi.org/10.1016/j.humimm.2016.04.020","mag":"2413530375","pmid":"https://pubmed.ncbi.nlm.nih.gov/27262453"},"language":"en","primary_location":{"id":"doi:10.1016/j.humimm.2016.04.020","doi":"https://doi.org/10.1016/j.humimm.2016.04.020","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.humimm.2016.04.020","pdf_url":null,"source":{"id":"https://openalex.org/S6860681","display_name":"Human Immunology","issn_l":"0198-8859","issn":["0198-8859","1879-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109074114","display_name":"Mohamed Madbouli Abdelrahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed M. Abdelrahman","raw_affiliation_strings":["Department of Pharmacology and Toxicology, German University in Cairo, New Cairo City, Main Entrance Al Tagamoa Al Khames, 11835 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, German University in Cairo, New Cairo City, Main Entrance Al Tagamoa Al Khames, 11835 Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048628113","display_name":"Injie Omar Fawzy","orcid":"https://orcid.org/0000-0003-4543-119X","observed_orcids":["https://orcid.org/0000-0003-4543-119X"]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Injie O. Fawzy","raw_affiliation_strings":["Department of Pharmacology and Toxicology, German University in Cairo, New Cairo City, Main Entrance Al Tagamoa Al Khames, 11835 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, German University in Cairo, New Cairo City, Main Entrance Al Tagamoa Al Khames, 11835 Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054125120","display_name":"A.A. Bassiouni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Aya A. Bassiouni","raw_affiliation_strings":["Department of Pharmacology and Toxicology, German University in Cairo, New Cairo City, Main Entrance Al Tagamoa Al Khames, 11835 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, German University in Cairo, New Cairo City, Main Entrance Al Tagamoa Al Khames, 11835 Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060704642","display_name":"Asmaa Ibrahim Gomaa","orcid":"https://orcid.org/0000-0001-9376-4461","observed_orcids":["https://orcid.org/0000-0001-9376-4461"]},"institutions":[{"id":"https://openalex.org/I4405261924","display_name":"National Liver Institute","ror":"https://ror.org/00avfvp71","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4405261924","https://openalex.org/I63601056"]},{"id":"https://openalex.org/I63601056","display_name":"Menoufia University","ror":"https://ror.org/05sjrb944","country_code":"EG","type":"education","lineage":["https://openalex.org/I63601056"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Asmaa I. Gomaa","raw_affiliation_strings":["Department of Hepatology, National Liver Institute, Menoufiya University, Menoufiya, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, National Liver Institute, Menoufiya University, Menoufiya, Egypt","institution_ids":["https://openalex.org/I4405261924","https://openalex.org/I63601056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029853696","display_name":"Gamal Esmat","orcid":"https://orcid.org/0000-0001-8614-1629","observed_orcids":["https://orcid.org/0000-0001-8614-1629"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Gamal Esmat","raw_affiliation_strings":["Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011520858","display_name":"Imam A. Waked","orcid":"https://orcid.org/0000-0002-9857-8972","observed_orcids":["https://orcid.org/0000-0002-9857-8972"]},"institutions":[{"id":"https://openalex.org/I4405261924","display_name":"National Liver Institute","ror":"https://ror.org/00avfvp71","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4405261924","https://openalex.org/I63601056"]},{"id":"https://openalex.org/I63601056","display_name":"Menoufia University","ror":"https://ror.org/05sjrb944","country_code":"EG","type":"education","lineage":["https://openalex.org/I63601056"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Imam Waked","raw_affiliation_strings":["Department of Hepatology, National Liver Institute, Menoufiya University, Menoufiya, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, National Liver Institute, Menoufiya University, Menoufiya, Egypt","institution_ids":["https://openalex.org/I4405261924","https://openalex.org/I63601056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011137431","display_name":"Ahmed Ihab Abdelaziz","orcid":"https://orcid.org/0000-0002-3367-2247","observed_orcids":["https://orcid.org/0000-0002-3367-2247"]},"institutions":[{"id":"https://openalex.org/I80693520","display_name":"American University in Cairo","ror":"https://ror.org/0176yqn58","country_code":"EG","type":"education","lineage":["https://openalex.org/I80693520"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Ahmed I. Abdelaziz","raw_affiliation_strings":["Department of Biology, American University in Cairo, New Cairo, Egypt. Electronic address: a.ihab@aucegypt.edu","Department of Biology, American University in Cairo, New Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, American University in Cairo, New Cairo, Egypt. Electronic address: a.ihab@aucegypt.edu","institution_ids":["https://openalex.org/I80693520"]},{"raw_affiliation_string":"Department of Biology, American University in Cairo, New Cairo, Egypt","institution_ids":["https://openalex.org/I80693520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5011137431"],"corresponding_institution_ids":["https://openalex.org/I80693520"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":3.2187,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.91944297,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"77","issue":"8","first_page":"667","last_page":"673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-182","display_name":"miR-182","score":0.9580000042915344},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8790000081062317},{"id":"https://openalex.org/keywords/nkg2d","display_name":"NKG2D","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nkg2a","display_name":"NKG2A","score":1.0},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.890999972820282},{"id":"https://openalex.org/keywords/perforin-1","display_name":"perforin-1","score":0.8989999890327454},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/huh7-cells","display_name":"Huh7 cells","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8133474588394165},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7772169709205627},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5163482427597046},{"id":"https://openalex.org/C3017392945","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatic carcinoma","level":3,"score":0.4112895727157593},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3370296359062195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2526942491531372},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06183266639709473},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.04275482892990112}],"mesh":[{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055654","descriptor_name":"NK Cell Lectin-Like Receptor Subfamily C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055654","descriptor_name":"NK Cell Lectin-Like Receptor Subfamily C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055655","descriptor_name":"NK Cell Lectin-Like Receptor Subfamily K","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055655","descriptor_name":"NK Cell Lectin-Like Receptor Subfamily K","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.humimm.2016.04.020","doi":"https://doi.org/10.1016/j.humimm.2016.04.020","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.humimm.2016.04.020","pdf_url":null,"source":{"id":"https://openalex.org/S6860681","display_name":"Human Immunology","issn_l":"0198-8859","issn":["0198-8859","1879-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Immunology","raw_type":"journal-article"},{"id":"pmid:27262453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27262453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W90172326","https://openalex.org/W1751395308","https://openalex.org/W1969950463","https://openalex.org/W1973852067","https://openalex.org/W1975390562","https://openalex.org/W1981989535","https://openalex.org/W1996787721","https://openalex.org/W2000288497","https://openalex.org/W2007173888","https://openalex.org/W2009378591","https://openalex.org/W2023743469","https://openalex.org/W2028968137","https://openalex.org/W2054298924","https://openalex.org/W2062903634","https://openalex.org/W2066667772","https://openalex.org/W2069357915","https://openalex.org/W2073300038","https://openalex.org/W2078990740","https://openalex.org/W2085338671","https://openalex.org/W2089154518","https://openalex.org/W2091976404","https://openalex.org/W2094381610","https://openalex.org/W2098100504","https://openalex.org/W2098150432","https://openalex.org/W2099229662","https://openalex.org/W2116779385","https://openalex.org/W2117225355","https://openalex.org/W2121024538","https://openalex.org/W2133968430","https://openalex.org/W2146313292","https://openalex.org/W2148923243","https://openalex.org/W2150687804","https://openalex.org/W2152105313","https://openalex.org/W2165903695","https://openalex.org/W2171202584","https://openalex.org/W2392304380","https://openalex.org/W3151241602","https://openalex.org/W6603583001","https://openalex.org/W6637761482"],"related_works":["https://openalex.org/W4406681963","https://openalex.org/W1850006434","https://openalex.org/W2903928179","https://openalex.org/W2619104463","https://openalex.org/W4399185640","https://openalex.org/W2741706728","https://openalex.org/W1862682763","https://openalex.org/W2069357915","https://openalex.org/W2467692530","https://openalex.org/W2312064315"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}