{"id":"https://openalex.org/W2413440323","doi":"https://doi.org/10.3390/ijms17060872","title":"Dehydroeburicoic Acid from Antrodia camphorata Prevents the Diabetic and Dyslipidemic State via Modulation of Glucose Transporter 4, Peroxisome Proliferator-Activated Receptor \u03b1 Expression and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice","display_name":"Dehydroeburicoic Acid from Antrodia camphorata Prevents the Diabetic and Dyslipidemic State via Modulation of Glucose Transporter 4, Peroxisome Proliferator-Activated Receptor \u03b1 Expression and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice","publication_year":2016,"publication_date":"2016-06-03","ids":{"openalex":"https://openalex.org/W2413440323","doi":"https://doi.org/10.3390/ijms17060872","mag":"2413440323","pmid":"https://pubmed.ncbi.nlm.nih.gov/27271603","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4926406"},"language":"en","primary_location":{"id":"doi:10.3390/ijms17060872","doi":"https://doi.org/10.3390/ijms17060872","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms17060872","pdf_url":"https://www.mdpi.com/1422-0067/17/6/872/pdf?version=1464957032","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/17/6/872/pdf?version=1464957032","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035972650","display_name":"Yueh\u2010Hsiung Kuo","orcid":"https://orcid.org/0000-0001-5935-6755","observed_orcids":["https://orcid.org/0000-0001-5935-6755"]},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yueh-Hsiung Kuo","raw_affiliation_strings":["Department of Biotechnology, Asia University, Taichung City 41354, Taiwan","Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung City 40402, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-5935-6755","affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Asia University, Taichung City 41354, Taiwan","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung City 40402, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100926638","display_name":"Cheng\u2010Hsiu Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121532","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/024w0ge69","country_code":"TW","type":"government","lineage":["https://openalex.org/I4210121532","https://openalex.org/I4405257903"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Hsiu Lin","raw_affiliation_strings":["Department of Internal Medicine, Fengyuan Hospital, Ministry of Health and Welfare, Fengyuan District, Taichung City 42055, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Fengyuan Hospital, Ministry of Health and Welfare, Fengyuan District, Taichung City 42055, Taiwan","institution_ids":["https://openalex.org/I4210121532"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082202432","display_name":"Chun\u2010Ching Shih","orcid":"https://orcid.org/0000-0003-4264-2602","observed_orcids":["https://orcid.org/0000-0003-4264-2602"]},"institutions":[{"id":"https://openalex.org/I882009436","display_name":"Central Taiwan University of Science and Technology","ror":"https://ror.org/03d4d3711","country_code":"TW","type":"education","lineage":["https://openalex.org/I882009436"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chun-Ching Shih","raw_affiliation_strings":["Graduate Institute of Pharmaceutical Science and Technology, College of Health Science, Central Taiwan University of Science and Technology, No. 666 Buzih Road, Beitun District, Taichung City 40601, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-4264-2602","affiliations":[{"raw_affiliation_string":"Graduate Institute of Pharmaceutical Science and Technology, College of Health Science, Central Taiwan University of Science and Technology, No. 666 Buzih Road, Beitun District, Taichung City 40601, Taiwan","institution_ids":["https://openalex.org/I882009436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082202432"],"corresponding_institution_ids":["https://openalex.org/I882009436"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":2.3054,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.8754673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"17","issue":"6","first_page":"872","last_page":"872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.19040000438690186,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antrodia-camphorata","display_name":"Antrodia camphorata","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triterpenoids","display_name":"triterpenoids","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7179999947547913},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/glut4","display_name":"GLUT4","score":0.7720000147819519},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.906000018119812},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7059999704360962},{"id":"https://openalex.org/keywords/glucose-6-phosphatase","display_name":"glucose-6-phosphatase","score":0.8069999814033508},{"id":"https://openalex.org/keywords/hepatic-glucose-production","display_name":"hepatic glucose production","score":0.7590000033378601},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/skeletal-muscle-glucose-uptake","display_name":"skeletal muscle glucose uptake","score":0.6209999918937683},{"id":"https://openalex.org/keywords/antidiabetic-effect","display_name":"antidiabetic effect","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.9001428484916687},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.7857486605644226},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.703559398651123},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6896567940711975},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.6780867576599121},{"id":"https://openalex.org/C2778150266","wikidata":"https://www.wikidata.org/wiki/Q7844989","display_name":"Troglitazone","level":4,"score":0.5963057279586792},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5513208508491516},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.5025022029876709},{"id":"https://openalex.org/C2778110834","wikidata":"https://www.wikidata.org/wiki/Q419724","display_name":"Fenofibrate","level":2,"score":0.490492045879364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48972490429878235},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.4618455767631531},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4344238042831421},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4299514591693878},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.42312559485435486},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3831915259361267},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.3152318298816681},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2763004004955292},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23661717772483826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20730939507484436}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007810","descriptor_name":"Lanosterol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007810","descriptor_name":"Lanosterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051275","descriptor_name":"Glucose Transporter Type 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051275","descriptor_name":"Glucose Transporter Type 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055491","descriptor_name":"Antrodia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms17060872","doi":"https://doi.org/10.3390/ijms17060872","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms17060872","pdf_url":"https://www.mdpi.com/1422-0067/17/6/872/pdf?version=1464957032","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3901028","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4926406","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27271603","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27271603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4926406","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4926406/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0f54bb6338ce488098d09129a6e2bfae","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0f54bb6338ce488098d09129a6e2bfae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 17, Iss 6, p 872 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms17060872","doi":"https://doi.org/10.3390/ijms17060872","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms17060872","pdf_url":"https://www.mdpi.com/1422-0067/17/6/872/pdf?version=1464957032","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309762","display_name":"Clinical Trial Center, China Medical University Hospital","ror":"https://ror.org/0368s4g32"},{"id":"https://openalex.org/F4320324301","display_name":"China Medical University","ror":"https://ror.org/032d4f246"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2413440323.pdf","grobid_xml":"https://content.openalex.org/works/W2413440323.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W140840762","https://openalex.org/W1510177883","https://openalex.org/W1969623264","https://openalex.org/W1979323366","https://openalex.org/W1981182541","https://openalex.org/W1982404045","https://openalex.org/W1989452171","https://openalex.org/W1993456360","https://openalex.org/W1996845220","https://openalex.org/W1999669918","https://openalex.org/W2007785262","https://openalex.org/W2017820712","https://openalex.org/W2023613912","https://openalex.org/W2025861882","https://openalex.org/W2031846075","https://openalex.org/W2040515085","https://openalex.org/W2042444876","https://openalex.org/W2055029805","https://openalex.org/W2057846722","https://openalex.org/W2059831744","https://openalex.org/W2060450937","https://openalex.org/W2062244719","https://openalex.org/W2066099619","https://openalex.org/W2070090402","https://openalex.org/W2077971415","https://openalex.org/W2078374645","https://openalex.org/W2081705352","https://openalex.org/W2103240729","https://openalex.org/W2105897175","https://openalex.org/W2107510101","https://openalex.org/W2112390367","https://openalex.org/W2125711274","https://openalex.org/W2126409614","https://openalex.org/W2138226825","https://openalex.org/W2142601896","https://openalex.org/W2144829836","https://openalex.org/W2145333208","https://openalex.org/W2150925908","https://openalex.org/W2151566924","https://openalex.org/W2154024784","https://openalex.org/W2156595285","https://openalex.org/W2157958154","https://openalex.org/W2158211242","https://openalex.org/W2165851630","https://openalex.org/W2169401893","https://openalex.org/W2302228386","https://openalex.org/W2315982688","https://openalex.org/W4240687645","https://openalex.org/W4246570572"],"related_works":["https://openalex.org/W2302228386","https://openalex.org/W2765590178","https://openalex.org/W2345934998","https://openalex.org/W2000476354","https://openalex.org/W2807043416","https://openalex.org/W2056295718","https://openalex.org/W2978673693","https://openalex.org/W2060450937","https://openalex.org/W2105897175","https://openalex.org/W2949642905"],"abstract_inverted_index":{"This":[0],"study":[1,38,79],"investigated":[2],"the":[3,20,40,55,89,181,188,255,341,360],"potential":[4],"effects":[5,21,41],"of":[6,24,42,48,58,61,92,121,130,198,212,222,229,235,241,257,274,290,303,318,362],"dehydroeburicoic":[7],"acid":[8,277,306,322],"(TT),":[9],"a":[10,43,245,335],"triterpenoid":[11],"compound":[12],"from":[13],"Antrodia":[14],"camphorata,":[15],"in":[16,31,36,72,77,203,206,217,249,267,309,334,337,347],"vitro":[17,37,78],"and":[18,22,28,51,70,86,97,123,194,259,286,311,314,327,343,366],"examined":[19,39],"mechanisms":[23],"TT":[25,87,131,168,252,353],"on":[26,64,157],"glucose":[27,66,93,166,173,237],"lipid":[29],"homeostasis":[30],"high-fat-diet":[32],"(HFD)-fed":[33],"mice.":[34,219,251,268],"The":[35,76,102,239],"MeOH":[44],"crude":[45],"extract":[46],"(CruE)":[47],"A.":[49],"camphorata":[50],"Antcin":[52],"K":[53],"(AnK;":[54],"main":[56],"constituent":[57],"fruiting":[59],"body":[60,141,148],"this":[62],"mushroom)":[63],"membrane":[65,90,210],"transporter":[67,94],"4":[68,95,154],"(GLUT4)":[69,96],"phospho-Akt":[71,98],"C2C12":[73],"myoblasts":[74],"cells.":[75],"demonstrated":[80],"that":[81,352],"treatment":[82,169,253,361],"with":[83,125],"CruE,":[84],"AnK":[85],"increased":[88,164,287],"levels":[91,174,197,211,228,289,302,317,346],"at":[99],"different":[100],"concentrations.":[101],"animal":[103],"experiments":[104],"were":[105,112,200,214],"performed":[106],"for":[107,152,359],"12":[108],"weeks.":[109],"Diabetic":[110],"mice":[111,162,186,223,270,297],"randomly":[113],"divided":[114],"into":[115],"six":[116],"groups":[117,205,221],"after":[118],"8":[119],"weeks":[120,155],"HFD-induction":[122],"treated":[124],"daily":[126],"oral":[127],"gavage":[128],"doses":[129],"(at":[132,138,145],"three":[133],"dose":[134],"levels),":[135],"fenofibrate":[136],"(Feno)":[137],"0.25":[139],"g/kg":[140,147],"weight),":[142],"metformin":[143],"(Metf)":[144],"0.3":[146],"weight)":[149],"or":[150],"vehicle":[151],"another":[153],"while":[156],"an":[158,233,355],"HFD":[159],"diet.":[160],"HFD-fed":[161],"exhibited":[163,271,299],"blood":[165,172],"levels.":[167],"dramatically":[170],"lowered":[171],"by":[175],"34.2%~43.4%,":[176],"which":[177],"was":[178],"comparable":[179],"to":[180],"antidiabetic":[182],"agent-Metf":[183],"(36.5%).":[184],"TT-treated":[185,218,250,269],"reduced":[187,315],"HFD-induced":[189],"hyperglycemia,":[190],"hypertriglyceridemia,":[191],"hyperinsulinemia,":[192],"hyperleptinemia,":[193],"hypercholesterolemia.":[195],"Membrane":[196],"GLUT4":[199,213],"significantly":[201,215],"higher":[202,216],"CruE-treated":[204],"vitro.":[207],"Skeletal":[208],"muscle":[209,261],"These":[220,296,331],"also":[224,298],"displayed":[225],"lower":[226,344],"mRNA":[227,288,316],"glucose-6-phosphatase":[230],"(G6":[231],"Pase),":[232],"inhibitor":[234],"hepatic":[236,258,275,319],"production.":[238],"combination":[240],"these":[242],"agents":[243],"produced":[244],"net":[246],"hypoglycemic":[247],"effect":[248],"enhanced":[254,272],"expressions":[256],"skeletal":[260],"AMP-activated":[262],"protein":[263,324],"kinase":[264],"(AMPK)":[265],"phosphorylation":[266],"expression":[273,301],"fatty":[276,305,321],"oxidation":[278],"enzymes,":[279],"including":[280],"peroxisome":[281],"proliferator-activated":[282],"receptor":[283],"\u03b1":[284],"(PPAR\u03b1)":[285],"carnitine":[291],"palmitoyl":[292],"transferase":[293],"Ia":[294],"(CPT-1a).":[295],"decreased":[300],"lipogenic":[304],"synthase":[307],"(FAS)":[308],"liver":[310,342],"adipose":[312],"tissue":[313],"adipocyte":[320],"binding":[323],"2":[325,364],"(aP2)":[326],"glycerol-3-phosphate":[328],"acyltransferase":[329],"(GPAT).":[330],"alterations":[332],"resulted":[333],"reduction":[336],"fat":[338],"stores":[339],"within":[340],"triglyceride":[345],"blood.":[348],"Our":[349],"results":[350],"demonstrate":[351],"is":[354],"excellent":[356],"therapeutic":[357],"approach":[358],"type":[363],"diabetes":[365],"hypertriglyceridemia.":[367]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}