{"id":"https://openalex.org/W2413153181","doi":null,"title":"High plasma levels of extrinsic pathway inhibitor and low levels of other coagulation inhibitors in advanced cancer.","display_name":"High plasma levels of extrinsic pathway inhibitor and low levels of other coagulation inhibitors in advanced cancer.","publication_year":1989,"publication_date":"1989-08-01","ids":{"openalex":"https://openalex.org/W2413153181","mag":"2413153181","pmid":"https://pubmed.ncbi.nlm.nih.gov/2596246"},"language":"en","primary_location":{"id":"pmid:2596246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2596246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta chirurgica Scandinavica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102229050","display_name":"A K Lindahl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A K Lindahl","raw_affiliation_strings":["Department of Surgery, Aker University Hospital, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Aker University Hospital, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112169486","display_name":"Sandset Pm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M Sandset","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005510617","display_name":"Ulrik Abildgaard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Abildgaard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029961725","display_name":"Andersson Tr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T R Andersson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028371856","display_name":"Harbitz Tb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T B Harbitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5216,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.8978763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"155","issue":"8","first_page":"389","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.8920000195503235},{"id":"https://openalex.org/keywords/protein-c","display_name":"protein C","score":0.9869999885559082},{"id":"https://openalex.org/keywords/heparin-cofactor-ii","display_name":"heparin cofactor II","score":0.996999979019165},{"id":"https://openalex.org/keywords/anticoagulants","display_name":"anticoagulants","score":0.9120000004768372},{"id":"https://openalex.org/keywords/advanced-cancer","display_name":"advanced cancer","score":0.925000011920929},{"id":"https://openalex.org/keywords/disease-stage","display_name":"disease stage","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cancer-associated-hypercoagulability","display_name":"cancer-associated hypercoagulability","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.8981534242630005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8011082410812378},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6156589388847351},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.6089479327201843},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5328177809715271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5199607610702515},{"id":"https://openalex.org/C2778162025","wikidata":"https://www.wikidata.org/wiki/Q14905348","display_name":"Heparin cofactor II","level":4,"score":0.46147701144218445},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.43759864568710327},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3973467946052551},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36632582545280457}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005167","descriptor_name":"Factor VII","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011486","descriptor_name":"Protein C","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013925","descriptor_name":"Thromboplastin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015844","descriptor_name":"Heparin Cofactor II","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2596246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2596246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta chirurgica Scandinavica","raw_type":"Journal Article"},{"id":"mag:2413153181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2596246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1983560802","https://openalex.org/W2334314796","https://openalex.org/W2028513701","https://openalex.org/W2409141335","https://openalex.org/W2468016558","https://openalex.org/W1993401670","https://openalex.org/W4283696823","https://openalex.org/W2088433892","https://openalex.org/W2070789618","https://openalex.org/W2229503053"],"abstract_inverted_index":{"Serial":[0],"determinations":[1],"of":[2,21,26,47,72,85,94,100,128,134,167],"plasma":[3],"coagulation":[4,159],"inhibitor":[5,40,78,160],"levels":[6,161],"were":[7,37,80],"performed":[8],"with":[9,17,44,171],"chromogenic":[10],"substrate":[11],"activity":[12,99],"assays":[13],"in":[14,64,68,82,169],"7":[15],"patients":[16,67,96,170],"cancer.":[18,172],"At":[19],"time":[20],"diagnosis":[22],"normal":[23,116,152],"median":[24,98],"activities":[25,41,79,127],"Antithrombin,":[27,50],"Protein":[28,51,135],"C,":[29],"Heparin":[30,54,141],"Cofactor":[31,55,142],"II":[32,56,143],"and":[33,53,108,140],"Extrinsic":[34,59,101],"Pathway":[35,60,102],"Inhibitor":[36,61,103],"found.":[38],"The":[39,77,158],"changed":[42],"significantly":[43,109,148],"the":[45,69,91,165],"progress":[46],"malignant":[48],"disease;":[49],"C":[52,136],"decreased":[57],"whereas":[58],"increased.":[62],"Determinations":[63],"13":[65],"additional":[66],"terminal":[70],"phase":[71],"cancer":[73],"confirmed":[74],"this":[75],"finding.":[76],"expressed":[81],"per":[83],"cent":[84],"a":[86],"pooled":[87],"reference":[88,117,153],"plasma.":[89],"In":[90],"total":[92],"series":[93],"20":[95],"studied,":[97],"was":[104,130],"183%":[105],"(range":[106,120,132,138,145],"61-378%)":[107],"(p":[110,154],"less":[111,155],"than":[112,156],"0.005)":[113],"above":[114],"age-adjusted":[115],"10":[118],"days":[119],"1-20":[121],"days)":[122],"prior":[123],"to":[124,164],"death.":[125],"Median":[126],"Antithrombin":[129],"59%":[131,144],"20-109%),":[133],"54%":[137],"24-130%)":[139],"33-110%),":[146],"all":[147],"below":[149],"age":[150],"adjusted":[151],"0.001).":[157],"seem":[162],"related":[163],"stage":[166],"disease":[168]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
