{"id":"https://openalex.org/W2413093802","doi":"https://doi.org/10.1136/jech-2015-206256.76","title":"OP77 The epigenetic clock and development during childhood and adolescence: longitudinal analysis from a UK birth cohort","display_name":"OP77 The epigenetic clock and development during childhood and adolescence: longitudinal analysis from a UK birth cohort","publication_year":2015,"publication_date":"2015-08-31","ids":{"openalex":"https://openalex.org/W2413093802","doi":"https://doi.org/10.1136/jech-2015-206256.76","mag":"2413093802"},"language":"en","primary_location":{"id":"doi:10.1136/jech-2015-206256.76","doi":"https://doi.org/10.1136/jech-2015-206256.76","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jech-2015-206256.76","pdf_url":null,"source":{"id":"https://openalex.org/S4306521614","display_name":"Oral Presentations","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Presentations","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104098736","display_name":"AJ Simpkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"AJ Simpkin","raw_affiliation_strings":["MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022945304","display_name":"Kate M. Tilling","orcid":"https://orcid.org/0000-0002-1010-8926","observed_orcids":["https://orcid.org/0000-0002-1010-8926"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K Tilling","raw_affiliation_strings":["MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032506215","display_name":"Laura D Howe","orcid":"https://orcid.org/0000-0003-3357-2796","observed_orcids":["https://orcid.org/0000-0003-3357-2796"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"LD Howe","raw_affiliation_strings":["MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036589831","display_name":"Tom R. Gaunt","orcid":"https://orcid.org/0000-0003-0924-3247","observed_orcids":["https://orcid.org/0000-0003-0924-3247"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"TR Gaunt","raw_affiliation_strings":["MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061995657","display_name":"Oliver Lyttleton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"O Lyttleton","raw_affiliation_strings":["ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033775892","display_name":"Wendy L. McArdle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"WL McCardle","raw_affiliation_strings":["ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005852380","display_name":"Susan M. Ring","orcid":"https://orcid.org/0000-0003-3103-9330","observed_orcids":["https://orcid.org/0000-0003-3103-9330"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"SM Ring","raw_affiliation_strings":["ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, UK","MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042511675","display_name":"Caroline Laura Relton","orcid":"https://orcid.org/0000-0003-2052-4840","observed_orcids":["https://orcid.org/0000-0003-2052-4840","https://orcid.org/0000-0001-7272-5308"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"CL Relton","raw_affiliation_strings":["Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UK","MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013184354","display_name":"George Davey Smith","orcid":"https://orcid.org/0000-0002-1407-8314","observed_orcids":["https://orcid.org/0000-0002-1407-8314"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G Davey Smith","raw_affiliation_strings":["MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Intergrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A43.1","last_page":"A43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-clocks","display_name":"epigenetic clocks","score":0.9810000061988831},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.847000002861023},{"id":"https://openalex.org/keywords/accelerated-aging","display_name":"accelerated aging","score":0.8119999766349792},{"id":"https://openalex.org/keywords/biological-aging","display_name":"biological aging","score":0.9660000205039978},{"id":"https://openalex.org/keywords/child-development","display_name":"child development","score":0.7390000224113464},{"id":"https://openalex.org/keywords/adolescence","display_name":"adolescence","score":0.9079999923706055},{"id":"https://openalex.org/keywords/height","display_name":"height","score":0.722000002861023},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.902999997138977},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.828000009059906},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.906000018119812},{"id":"https://openalex.org/keywords/avon-longitudinal-study-of-parents-and-children","display_name":"Avon Longitudinal Study of Parents and Children","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6060140132904053},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5905843377113342},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.5888314247131348},{"id":"https://openalex.org/C117896860","wikidata":"https://www.wikidata.org/wiki/Q11376","display_name":"Acceleration","level":2,"score":0.5481879115104675},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.5328398942947388},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.5120523571968079},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4705023467540741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41480785608291626},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3412681519985199},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2694784104824066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23568424582481384},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1989293396472931},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15534594655036926},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15113580226898193},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1324310302734375},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jech-2015-206256.76","doi":"https://doi.org/10.1136/jech-2015-206256.76","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jech-2015-206256.76","pdf_url":null,"source":{"id":"https://openalex.org/S4306521614","display_name":"Oral Presentations","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Presentations","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4099999964237213,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2572544607","https://openalex.org/W2800587679","https://openalex.org/W4365150643","https://openalex.org/W4414392909","https://openalex.org/W6977278589","https://openalex.org/W2853644493","https://openalex.org/W2990385305","https://openalex.org/W4319748026","https://openalex.org/W2980520436","https://openalex.org/W2608611988"],"abstract_inverted_index":{"Background":[0],"Statistical":[1],"models":[2,164],"(known":[3],"as":[4,43,127,320],"epigenetic":[5,105,195,271,300],"clocks)":[6],"that":[7,295],"use":[8],"an":[9,206],"individual\u2019s":[10],"DNA":[11,79,110,278,353],"methylation":[12,80,111,279],"to":[13,51,108,167,184],"predict":[14],"their":[15],"age":[16,37,54,85,112,142,199,214,219,234,252,267,318],"have":[17,292],"recently":[18],"been":[19],"developed,":[20],"with":[21,58,146,200,225,281,306],"96%":[22,204,285],"correlation":[23,174,202,283],"found":[24,293],"between":[25,133,210,286],"predicted":[26,134,197,211,289],"and":[27,62,87,99,135,172,179,205,212,244,263,288,309,352],"chronological":[28,287],"age.":[29,137,290],"Departures":[30],"of":[31,46,97,130,149,203,215,233,251,277,284,298,316,323,348],"predictions":[32],"from":[33,68,92,266],"actual":[34,136,198,213],"age,":[35],"called":[36],"acceleration":[38,55,120,143,220,319],"residuals,":[39],"can":[40],"be":[41],"used":[42,103,166,183],"a":[44,69,128,201,274,282,321],"measure":[45,129,322],"biological":[47],"ageing.":[48],"We":[49,77,102,138,291],"aimed":[50],"investigate":[52],"whether":[53,141],"was":[56,144,223,330],"associated":[57,145,224,305],"development":[59,324],"during":[60,261],"childhood":[61,262],"adolescence":[63,264],"using":[64,317],"repeated":[65,147,346],"measures":[66,148],"data":[67,334],"large":[70],"birth":[71,177,222,303],"cohort":[72],"in":[73,89,175,325,332],"the":[74,93,104,131,176,194,314],"UK.":[75],"Methods":[76],"obtained":[78,123],"at":[81,116,221,302],"three":[82],"clinics":[83],"(birth,":[84],"7":[86],"17)":[88],"1018":[90],"children":[91],"Avon":[94],"Longitudinal":[95],"Study":[96],"Parents":[98],"Children":[100],"(ALSPAC).":[101],"clock":[106,196,272,301],"algorithm":[107],"obtain":[109],"for":[113,124,169,186],"each":[114,117,125],"child":[115],"clinic.":[118],"Age":[119],"residuals":[121],"were":[122,165,182],"sample":[126],"difference":[132,209],"then":[139],"investigated":[140],"height,":[150],"weight,":[151],"BMI,":[152],"bone":[153,156],"mineral":[154],"density,":[155],"mass,":[157],"fat":[158,245,310],"mass":[159,246],"or":[160],"lean":[161],"mass.":[162,311],"Multilevel":[163],"account":[168,185],"both":[170,349],"between-":[171],"within-individual":[173],"cohort,":[178],"spline":[180],"terms":[181],"nonlinear":[187],"trajectories":[188],"over":[189],"time.":[190],"Results":[191],"In":[192],"ALSPAC,":[193],"average":[207,227],"absolute":[208],"2.9":[216],"years.":[217],"Positive":[218],"higher":[226],"height":[228,308],"(0.65":[229],"cm":[230],"per":[231,249],"year":[232,250],"acceleration,":[235,253],"95%":[236,254],"CI":[237,255],"0.02":[238],"cm\u20131.29":[239],"cm;":[240],"p":[241,258],"=":[242,259],"0.044)":[243],"(1.39":[247],"kg":[248],"0.54\u20132.34":[256],"kg;":[257],"0.002)":[260],"(i.e.,":[265],"0\u201317).":[268],"Discussion":[269],"The":[270],"represents":[273],"useful":[275],"application":[276],"data,":[280],"evidence":[294],"being":[296],"ahead":[297],"one\u2019s":[299],"is":[304],"increased":[307],"This":[312],"demonstrates":[313],"potential":[315],"future":[326],"research.":[327],"Our":[328],"analysis":[329],"limited":[331],"having":[333],"available":[335],"until":[336],"17":[337],"rather":[338],"than":[339],"into":[340],"adulthood,":[341],"but":[342],"our":[343],"strengths":[344],"include":[345],"measurements":[347],"developmental":[350],"responses":[351],"methylation.":[354]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}
