{"id":"https://openalex.org/W2412974809","doi":null,"title":"[Triflusal in the prevention of vascular dementia].","display_name":"[Triflusal in the prevention of vascular dementia].","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W2412974809","mag":"2412974809","pmid":"https://pubmed.ncbi.nlm.nih.gov/9462972"},"language":"es","primary_location":{"id":"pmid:9462972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9462972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de neurologia","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012336996","display_name":"Secundino L\u00f3pez Pousa","orcid":"https://orcid.org/0000-0002-2818-3473","observed_orcids":["https://orcid.org/0000-0002-2818-3473"]},"institutions":[{"id":"https://openalex.org/I157913058","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04","country_code":"ES","type":"government","lineage":["https://openalex.org/I157913058"]},{"id":"https://openalex.org/I4210121211","display_name":"Hospital Santa Caterina","ror":"https://ror.org/036dkm174","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210121211"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"S L\u00f3pez-Pousa","raw_affiliation_strings":["Unitat de Valoraci\u00f3 de la Mem\u00f2ria i les Dem\u00e8ncies, Departament de Sanitat, Generalitat de Catalunya, Hospital Santa Caterina, Girona, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat de Valoraci\u00f3 de la Mem\u00f2ria i les Dem\u00e8ncies, Departament de Sanitat, Generalitat de Catalunya, Hospital Santa Caterina, Girona, Espa\u00f1a","institution_ids":["https://openalex.org/I157913058","https://openalex.org/I4210121211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037137899","display_name":"J Mercadal-Dalmau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Mercadal-Dalmau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042501095","display_name":"Mart\u00ed-Cuadros Am","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A M Mart\u00ed-Cuadros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038802405","display_name":"Joan Vilalta Franch","orcid":"https://orcid.org/0000-0002-5306-437X","observed_orcids":["https://orcid.org/0000-0002-5306-437X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Vilalta-Franch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109201211","display_name":"Manuela Lozano Gallego","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Lozano-Gallego","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5083,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.69613541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"146","first_page":"1525","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.798799991607666,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.798799991607666,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.19099999964237213,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triflusal","display_name":"triflusal","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antiplatelet-drugs","display_name":"antiplatelet agents","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7080000042915344},{"id":"https://openalex.org/keywords/mini-mental-state-examination","display_name":"Mini-Mental State Examination","score":0.7799999713897705},{"id":"https://openalex.org/keywords/stroke-risk-factors","display_name":"stroke risk factors","score":0.4390000104904175},{"id":"https://openalex.org/keywords/dementia-prevention","display_name":"dementia prevention","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.8466489315032959},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.7684480547904968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7236284613609314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46898704767227173},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.45134633779525757},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.41021811962127686},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37257274985313416}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012459","descriptor_name":"Salicylates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9462972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9462972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de neurologia","raw_type":"Clinical Trial"},{"id":"mag:2412974809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9462972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2914264896","https://openalex.org/W937319193","https://openalex.org/W7098593753","https://openalex.org/W4296343890","https://openalex.org/W1992318681","https://openalex.org/W2366881375","https://openalex.org/W3036176789","https://openalex.org/W7100041933","https://openalex.org/W2435618142","https://openalex.org/W2017544087"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Vascular":[1],"dementia":[2,9,90],"is":[3,20,209],"the":[4,28,51,68,105,111,116,119,135,151,158,180,184],"second":[5],"commonest":[6],"cause":[7],"of":[8,33,38,70,85,107,113,118,129,138,197,215],"after":[10,125],"Alzheimer's":[11],"disease.":[12],"The":[13,177],"most":[14],"important":[15],"risk":[16,29],"factor":[17],"for":[18],"this":[19,34,173],"previous":[21],"cerebral":[22],"vascular":[23,73,89,218],"accident.":[24],"OBJECTIVE:":[25],"To":[26,103],"eliminate":[27],"factors":[30],"and/or":[31],"progression":[32],"illness":[35],"would":[36],"be":[37,142],"considerable":[39],"benefit":[40],"to":[41,50,141,211],"these":[42],"patients.":[43],"Triflusal,":[44],"a":[45,83,126,143,166,194,205],"platelet":[46],"anti-aggregant":[47],"chemically":[48],"related":[49],"salicylates,":[52],"whose":[53],"clinical":[54,127],"efficacy":[55,106,140],"has":[56,64],"been":[57,65],"shown":[58],"in":[59,67,115,157,179],"cardiac":[60],"and":[61,97,156],"cerebrovascular":[62],"pathology,":[63],"used":[66,124],"treatment":[69,99,108],"patients":[71,87],"with":[72,88,100,109,161,193,217],"dementia.":[74,219],"MATERIAL":[75],"AND":[76],"METHODS:":[77],"An":[78],"open":[79],"study":[80],"was":[81,123,170,187],"done":[82],"sample":[84],"73":[86],"randomly":[91],"distributed":[92],"into":[93],"two":[94,185],"groups":[95,186],"(control":[96],"undergoing":[98],"triflusal).":[101],"RESULTS:":[102],"check":[104],"triflusal,":[110],"percentage":[112],"variation":[114],"scoring":[117],"Cognitive":[120],"Mini":[121],"Examination":[122],"course":[128,168],"12":[130,182],"months":[131],"(IVP":[132],"12),":[133],"considering":[134],"critical":[136,174],"point":[137],"no":[139],"loss":[144],"equal":[145],"or":[146],"greater":[147,171],"than":[148,172],"10%.":[149],"In":[150],"control":[152],"group,":[153],"33%":[154],"(8/24)":[155],"group":[159],"treated":[160],"triflusal":[162,204],"8%":[163],"(3/35)":[164],"had":[165],"negative":[167],"which":[169,208],"point.":[175],"CONCLUSIONS:":[176],"difference":[178],"IVP":[181],"between":[183],"statistically":[188],"significant":[189],"(p":[190],"=":[191,200],"0.0375),":[192],"statistical":[195],"power":[196],"87%":[198],"(beta":[199],"0.13).":[201],"This":[202],"gives":[203],"therapeutic":[206],"activity":[207],"sufficient":[210],"limit":[212],"cognitive":[213],"deterioration":[214],"patient":[216]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}