{"id":"https://openalex.org/W2412929454","doi":null,"title":"Granulocyte colony-stimulating factor administration reverses cadmium-associated inhibition of hepatocyte regeneration.","display_name":"Granulocyte colony-stimulating factor administration reverses cadmium-associated inhibition of hepatocyte regeneration.","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W2412929454","mag":"2412929454","pmid":"https://pubmed.ncbi.nlm.nih.gov/8864679"},"language":"en","primary_location":{"id":"pmid:8864679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8864679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gastroenterology & hepatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113618523","display_name":"S. Theocharis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S E Theocharis","raw_affiliation_strings":["Department of Histology and Embryology, School of Medicine, University of Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, School of Medicine, University of Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016531769","display_name":"A. Margelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A P Margeli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108449382","display_name":"N. Goutas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N D Goutas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024567950","display_name":"Maria Horti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M G Horti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055339446","display_name":"Christos Karkantaris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C S Karkantaris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008899846","display_name":"Kittas Cn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C N Kittas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4874,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.64770524,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":"8","first_page":"805","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":1.0},{"id":"https://openalex.org/keywords/cadmium-toxicity","display_name":"cadmium toxicity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hepatocyte-regeneration","display_name":"hepatocyte regeneration","score":0.9319999814033508},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/thymidine-kinase-activity","display_name":"thymidine kinase activity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.8820000290870667},{"id":"https://openalex.org/keywords/mitotic-index","display_name":"mitotic index","score":0.8519999980926514},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.6140000224113464},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.7947514057159424},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.7516495585441589},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.6467409133911133},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6247018575668335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6237366199493408},{"id":"https://openalex.org/C66640590","wikidata":"https://www.wikidata.org/wiki/Q4296711","display_name":"Mitotic index","level":3,"score":0.6200881600379944},{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.5945632457733154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45041486620903015},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.4419757127761841},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.437584787607193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3036884665489197},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.2548581659793854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21235865354537964},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.11701080203056335},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10211181640625},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10151398181915283},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.10028338432312012},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.09921562671661377}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008940","descriptor_name":"Mitotic Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8864679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8864679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gastroenterology & hepatology","raw_type":"Journal Article"},{"id":"mag:2412929454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8864679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W249393410","https://openalex.org/W2311280870","https://openalex.org/W2083808104","https://openalex.org/W2027616563","https://openalex.org/W2071798105","https://openalex.org/W2152120501","https://openalex.org/W2002391829","https://openalex.org/W4244066167","https://openalex.org/W2102014451","https://openalex.org/W2063309707"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"document":[2],"whether":[3],"the":[4,12,61,111,138,167],"administration":[5,104,160],"of":[6,16,99,140,156,161,174],"granulocyte":[7],"colony-stimulating":[8],"factor":[9],"(G-CSF)":[10],"enhances":[11],"impaired":[13,168],"regenerative":[14,68],"response":[15],"hepatocytes":[17,145],"to":[18,121,124],"partial":[19],"hepatectomy":[20],"(PH),":[21],"in":[22,55,105,127,144,149,171],"cadmium-pretreated":[23,56,106,152],"partially":[24,57,107,131,153],"hepatectomized":[25,58,108,132,154],"rats.":[26,157],"MATERIALS":[27],"AND":[28],"METHODS:":[29],"Rats":[30],"were":[31,95,130,146],"injected":[32],"intraperioneally":[33],"with":[34],"2.5":[35],"mg":[36],"CdCl2/kg":[37],"body":[38,48],"weight,":[39],"24h":[40,72],"before":[41],"PH.":[42,65,74],"G-CSF":[43,103,150,162],"(1500":[44],"or":[45,50],"150":[46],"micrograms/kg":[47],"weight)":[49],"saline":[51],"was":[52,70],"administered":[53,151],"intraperitoneally":[54],"rats":[59,109,128],"at":[60],"same":[62],"time":[63],"as":[64,97],"The":[66,134,159],"liver":[67,79,81,169],"process":[69],"estimated":[71],"after":[73],"[3H]":[75],"thymidine":[76,82],"incorporation":[77],"into":[78],"DNA,":[80],"kinase":[83],"(TK)":[84],"activity,":[85],"mitotic":[86,135],"index":[87,136],"and":[88,115,137],"proliferating":[89],"cell":[90],"nuclear":[91],"antigen":[92],"(PCNA)":[93],"immunostaining":[94],"used":[96],"indices":[98],"hepatocyte":[100,176],"proliferation.":[101,177],"RESULTS:":[102],"restored":[110],"suppressed":[112],"DNA":[113],"biosynthesis":[114],"TK":[116],"activity":[117],"(P":[118],"<":[119],"0.001),":[120],"levels":[122],"similar":[123],"those":[125],"found":[126],"that":[129,165],"only.":[133],"percentage":[139],"PCNA":[141],"positive":[142],"nuclei":[143],"also":[147],"enhanced":[148],"groups":[155],"CONCLUSION:":[158],"triggers":[163],"events":[164],"restore":[166],"regeneration":[170],"this":[172],"model":[173],"reduced":[175]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}