{"id":"https://openalex.org/W2412912989","doi":null,"title":"Bed rest immobilization with various oral sodium supply: plasma hormones and body fluids.","display_name":"Bed rest immobilization with various oral sodium supply: plasma hormones and body fluids.","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W2412912989","mag":"2412912989","pmid":"https://pubmed.ncbi.nlm.nih.gov/12466015"},"language":"en","primary_location":{"id":"pmid:12466015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12466015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine regulations","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110025429","display_name":"Helmut G Hinghofer-Szalkay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Helmut G Hinghofer-Szalkay","raw_affiliation_strings":["Institute for Adaptive Spaceflight Physiology, Graz, Austria. helmut.hinghofer@uni-graz.at"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Adaptive Spaceflight Physiology, Graz, Austria. helmut.hinghofer@uni-graz.at","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112619564","display_name":"Zoltan L\u00e1szl\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117895","display_name":"Szent J\u00e1nos K\u00f3rh\u00e1z","ror":"https://ror.org/024pgmp43","country_code":"HU","type":"healthcare","lineage":["https://openalex.org/I4210117895"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zolt\u00e1n L\u00e1szl\u00f3","raw_affiliation_strings":["Szent J\u00e1nos K\u00f3rh\u00e1z / Szent J\u00e1nos K\u00f3rh\u00e1z \u00e9s \u00c9szak-budai Egyes\u00edtett K\u00f3rh\u00e1zak"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Szent J\u00e1nos K\u00f3rh\u00e1z / Szent J\u00e1nos K\u00f3rh\u00e1z \u00e9s \u00c9szak-budai Egyes\u00edtett K\u00f3rh\u00e1zak","institution_ids":["https://openalex.org/I4210117895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023082493","display_name":"Daniela Je\u017eov\u00e1","orcid":"https://orcid.org/0000-0003-1932-2950","observed_orcids":["https://orcid.org/0000-0003-1932-2950"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Daniela Jezova","raw_affiliation_strings":["Slovak Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Slovak Academy of Sciences","institution_ids":["https://openalex.org/I207624831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110771216","display_name":"Andreas R\u00f6ssler","orcid":"https://orcid.org/0000-0001-9543-8870","observed_orcids":["https://orcid.org/0000-0001-9543-8870"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andreas R\u00f6ssler","raw_affiliation_strings":["University of Graz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Graz","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031096409","display_name":"Bernd Haditsch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernd Haditsch","raw_affiliation_strings":["Inst. Adaptive Spaceflight Physiol"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inst. Adaptive Spaceflight Physiol","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016457543","display_name":"Karl Pilz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karl Pilz","raw_affiliation_strings":["Inst. Adaptive Spaceflight Physiol"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inst. Adaptive Spaceflight Physiol","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052966023","display_name":"Herfried Passath","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herfried Passath","raw_affiliation_strings":["Inst. Adaptive Spaceflight Physiol"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inst. Adaptive Spaceflight Physiol","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046392071","display_name":"Hermann Scharfetter","orcid":"https://orcid.org/0000-0003-2534-3213","observed_orcids":["https://orcid.org/0000-0003-2534-3213"]},"institutions":[{"id":"https://openalex.org/I4092182","display_name":"Graz University of Technology","ror":"https://ror.org/00d7xrm67","country_code":"AT","type":"education","lineage":["https://openalex.org/I4092182"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Hermann Sharfetter","raw_affiliation_strings":["Graz University of Technology,#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graz University of Technology,#TAB#","institution_ids":["https://openalex.org/I4092182"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.201,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53234384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"36","issue":"4","first_page":"151","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-down-bed-rest","display_name":"head-down bed rest","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dietary-sodium","display_name":"dietary sodium","score":0.6380000114440918},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.8389999866485596},{"id":"https://openalex.org/keywords/extracellular-volume","display_name":"extracellular volume","score":0.9869999885559082},{"id":"https://openalex.org/keywords/transthoracic-impedance","display_name":"thoracic impedance","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2777854218","wikidata":"https://www.wikidata.org/wiki/Q850197","display_name":"Bed rest","level":2,"score":0.7996015548706055},{"id":"https://openalex.org/C2113261","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Extracellular fluid","level":3,"score":0.7871483564376831},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.7429459095001221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6868720054626465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6831445693969727},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6416969299316406},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.4986112117767334},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4941425621509552},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.49369725584983826},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4783201217651367},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.4648752510547638},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2286832630634308},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.21772807836532593},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1456611454486847},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09818398952484131},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001510","descriptor_name":"Bed Rest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001826","descriptor_name":"Body Fluids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007103","descriptor_name":"Immobilization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012982","descriptor_name":"Sodium, Dietary","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018474","descriptor_name":"Weightlessness Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018475","descriptor_name":"Head-Down Tilt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12466015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12466015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine regulations","raw_type":"Clinical Trial"},{"id":"mag:2412912989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12466015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3178847398","https://openalex.org/W182215470","https://openalex.org/W2043997059","https://openalex.org/W7100544865","https://openalex.org/W2267910582","https://openalex.org/W2405274604","https://openalex.org/W2077010927","https://openalex.org/W2020535479","https://openalex.org/W1979460097","https://openalex.org/W1992817970"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"answer":[2],"the":[3,83,141,195,213,234],"question":[4],"if":[5],"plasma":[6,105,186],"hormone":[7,131,164],"concentrations":[8],"(plasma":[9],"renin":[10],"activity--PRA,":[11],"vasopressin--pAVP,":[12],"and":[13,60,81,89,94,100,104,111,231],"aldosterone":[14,99,187],"concentration)":[15],"due":[16,240],"to":[17,125,241],"antiorthostatic":[18],"immobilization":[19],"(8":[20],"days":[21,41,47],"-6":[22],"degree":[23],"head-down":[24],"tilt":[25],"bed":[26,244],"rest--HDBR)":[27],"are":[28,218],"altered":[29,168],"by":[30,45,169,202,221,226,249],"oral":[31,222],"salt":[32,161,223],"load,":[33],"we":[34],"provided":[35,70],"constant":[36],"sodium":[37,67,207,254],"supply":[38],"during":[39],"4":[40],"ambulatory":[42],"conditions":[43],"followed":[44],"8":[46],"HDBR":[48,150,198],"in":[49,71,128,177,180],"10":[50,58],"normotensive":[51],"men.":[52],"METHODS:":[53],"A":[54],"low'":[55],"(LS:":[56,151],"143":[57],"mM)":[59],"high'":[61],"(HS:":[62,188],"434+/-17":[63],"mM":[64],"Na+/d":[65],"excreted)":[66],"treatment":[68],"were":[69,92,113,133,166],"randomized":[72],"order,":[73],"separated":[74],">":[75],"or":[76],"=":[77],"1":[78],"mo.":[79],"Before":[80],"at":[82],"end":[84],"of":[85,205,236,252],"HDBR,":[86,170],"hemodynamic":[87],"variables":[88],"thoracic":[90],"impedance":[91,121],"determined,":[93],"blood":[95],"was":[96,123,173,185],"taken":[97],"for":[98],"PRA,":[101],"venous":[102],"hematocrit,":[103],"mass":[106,137],"density.":[107],"Extracellular":[108,146],"fluid":[109,238],"volume":[110,147,201,239],"pAVP":[112,172],"determined":[114],"every":[115],"second":[116],"day.":[117],"Whole":[118],"body":[119],"electrical":[120],"spectroscopy":[122],"employed":[124],"assess":[126],"changes":[127,251],"extracellular":[129,200,237],"volume,":[130],"determinations":[132],"done":[134],"with":[135,140,149],"radioimmunoassay,":[136],"density":[138],"measurements":[139],"mechanical":[142],"oscillator":[143],"technique.":[144],"RESULTS:":[145],"decreased":[148],"-4.0%,":[152],"p=0.002;":[153],"HS:":[154],"-5.8%,":[155],"p=0.018)":[156],"without":[157],"significant":[158],"difference":[159],"between":[160],"treatments.":[162],"Resting":[163],"levels":[165],"not":[167,247],"but":[171],"lower":[174],"(5.5+/-0.1":[175],"pg/ml)":[176,183],"HS":[178],"than":[179,225],"LS":[181],"(7.2+/-0.3":[182],"as":[184],"69+/-7":[189],"pg/ml,":[190],"LS:":[191],"180+/-24":[192],"pg/ml).":[193],"On":[194],"other":[196],"hand,":[197],"reduced":[199],"?5%":[203],"irrespective":[204],"dietary":[206,253],"supply.":[208,255],"CONCLUSIONS:":[209],"Our":[210],"data":[211],"support":[212],"hypothesis":[214],"that":[215,233],"hormonal":[216],"activities":[217],"more":[219],"affected":[220],"load":[224],"simulated":[227],"short-term":[228],"space":[229],"flight,":[230],"suggest":[232],"reduction":[235],"head":[242],"down":[243],"rest":[245],"is":[246],"influenced":[248],"moderate":[250]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}