{"id":"https://openalex.org/W2412543741","doi":null,"title":"[Features of memantine action profile in cholinergic deficit and intracerebral posttraumatic hematoma (hemorrhagic stroke) models in rats].","display_name":"[Features of memantine action profile in cholinergic deficit and intracerebral posttraumatic hematoma (hemorrhagic stroke) models in rats].","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2412543741","mag":"2412543741","pmid":"https://pubmed.ncbi.nlm.nih.gov/18488899"},"language":"ru","primary_location":{"id":"pmid:18488899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18488899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eksperimental'naia i klinicheskaia farmakologiia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086528336","display_name":"\u0422. \u041b. \u0413\u0430\u0440\u0438\u0431\u043e\u0432\u0430","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T L Garibova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057380490","display_name":"\u0422\u0430\u0442\u044c\u044f\u043d\u0430 \u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440\u043e\u0432\u043d\u0430 \u0412\u043e\u0440\u043e\u043d\u0438\u043d\u0430","orcid":"https://orcid.org/0000-0001-7065-469X","observed_orcids":["https://orcid.org/0000-0001-7065-469X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T A Voronina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078900624","display_name":"\u0421\u0432\u0435\u0442\u043b\u0430\u043d\u0430 \u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440\u043e\u0432\u043d\u0430 \u041b\u0438\u0442\u0432\u0438\u043d\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-9139-2334","observed_orcids":["https://orcid.org/0000-0001-9139-2334"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Litvinova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042415771","display_name":"Kuznetsova Al","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A L Kuznetsova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012108381","display_name":"\u041a\u0443\u043b\u044c\u0447\u0438\u043a\u043e\u0432 \u0410\u043d\u0434\u0440\u0435\u0439 \u0415\u0432\u0433\u0435\u043d\u044c\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0003-0470-1245","observed_orcids":["https://orcid.org/0000-0003-0470-1245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A E Kul'chikov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034331502","display_name":"A V Alesenko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A V Alesenko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.375,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.5670402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"71","issue":"2","first_page":"8","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.13650000095367432,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.09049999713897705,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":1.0},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cholinergic-deficit","display_name":"cholinergic deficit","score":0.9279999732971191},{"id":"https://openalex.org/keywords/scopolamine","display_name":"scopolamine","score":0.9110000133514404},{"id":"https://openalex.org/keywords/intracerebral-hematoma","display_name":"intracerebral hematoma","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hemorrhagic-stroke","display_name":"hemorrhagic stroke","score":0.9480000138282776},{"id":"https://openalex.org/keywords/learning-disabilities","display_name":"learning disabilities","score":0.4729999899864197},{"id":"https://openalex.org/keywords/emotional-stress","display_name":"emotional stress","score":0.7360000014305115},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.8349999785423279},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.9405006170272827},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6204017400741577},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6027269959449768},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.5600677132606506},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.5175223350524902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5148910284042358},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5047911405563354},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.45696040987968445},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4559895992279053},{"id":"https://openalex.org/C2779662492","wikidata":"https://www.wikidata.org/wiki/Q468787","display_name":"Hematoma","level":2,"score":0.43432703614234924},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.42043134570121765},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3972702920436859},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.3912785053253174},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23590010404586792},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21602168679237366},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.12543869018554688},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002543","descriptor_name":"Cerebral Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D002543","descriptor_name":"Cerebral Hemorrhage","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003213","descriptor_name":"Conditioning, Psychological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006406","descriptor_name":"Hematoma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006406","descriptor_name":"Hematoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008559","descriptor_name":"Memantine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18488899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18488899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eksperimental'naia i klinicheskaia farmakologiia","raw_type":"Journal Article"},{"id":"mag:2412543741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18488899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W197594573","https://openalex.org/W2094842927","https://openalex.org/W2921317743","https://openalex.org/W6907767764","https://openalex.org/W2083890595","https://openalex.org/W2002827758","https://openalex.org/W2550281893","https://openalex.org/W2094921102","https://openalex.org/W2060397937","https://openalex.org/W2014156489"],"abstract_inverted_index":{"Memantine,":[0],"a":[1,12],"low-affinity":[2],"non-competitive":[3],"antagonist":[4],"of":[5,15,24,34,44,47,63,91],"glutamatergic":[6],"NMDA-subtype":[7],"receptors,":[8],"was":[9],"used":[10],"at":[11],"daily":[13],"dose":[14],"1":[16],"mg/kg":[17],"over":[18],"10":[19],"days":[20,84],"for":[21,82],"the":[22,31,45,60,89,94,108],"treatment":[23],"rats":[25],"with":[26,73],"cholinergic":[27],"deficit":[28],"induced":[29],"by":[30],"chronic":[32],"administration":[33],"scopolamine":[35],"(1":[36],"mg/kg,":[37,81],"20":[38],"days).":[39],"The":[40],"drug":[41],"prevented":[42,88],"violation":[43],"learning":[46],"conditioned":[48,98],"active":[49],"and":[50,54,103],"passive":[51,99],"avoidance":[52,100],"reflexes":[53],"produced":[55],"no":[56],"significant":[57],"effect":[58],"on":[59],"emotional":[61,105],"state":[62],"animals":[64,72],"in":[65,107],"elevated":[66],"plus":[67],"maze":[68],"(EPM)":[69],"test.":[70,110],"In":[71],"intracerebral":[74],"posttraumatic":[75],"hematoma":[76],"(hemorrhagic":[77],"stroke),":[78],"memantine":[79],"(2":[80],"3":[83],"after":[85],"operation)":[86],"completely":[87],"loss":[90],"animals,":[92],"reduced":[93],"neurological":[95],"deficit,":[96],"improved":[97],"reflex":[101],"performance,":[102],"decreased":[104],"stress":[106],"EPM":[109]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}