{"id":"https://openalex.org/W2412475186","doi":null,"title":"The effect of selective serotonin reuptake inhibitors in healthy first-degree relatives of patients with major depressive disorder - an experimental medicine blinded controlled trial.","display_name":"The effect of selective serotonin reuptake inhibitors in healthy first-degree relatives of patients with major depressive disorder - an experimental medicine blinded controlled trial.","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2412475186","mag":"2412475186","pmid":"https://pubmed.ncbi.nlm.nih.gov/22459724"},"language":"en","primary_location":{"id":"pmid:22459724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22459724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Danish medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007536391","display_name":"Ulla Knorr","orcid":"https://orcid.org/0000-0002-1222-1527","observed_orcids":["https://orcid.org/0000-0002-1222-1527"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Ulla Benedichte Knorr","raw_affiliation_strings":["Psychiatric Centre Copenhagen, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark. ulla.knorr@regionh.dk","Psychiatric Centre Copenhagen, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric Centre Copenhagen, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark. ulla.knorr@regionh.dk","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]},{"raw_affiliation_string":"Psychiatric Centre Copenhagen, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007536391"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"],"apc_list":null,"apc_paid":null,"fwci":0.1248,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.41297367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"59","issue":"4","first_page":"B4426","last_page":"B4426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.5458999872207642,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.5458999872207642,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.399399995803833,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/escitalopram","display_name":"escitalopram","score":0.9940000176429749},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9359999895095825},{"id":"https://openalex.org/keywords/first-degree-relatives","display_name":"first-degree relatives","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cortisol-response","display_name":"cortisol response","score":0.6669999957084656},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neuroticism","display_name":"neuroticism","score":0.9850000143051147},{"id":"https://openalex.org/keywords/personality","display_name":"personality","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.902999997138977},{"id":"https://openalex.org/keywords/depression-biomarkers","display_name":"depression biomarkers","score":0.6790000200271606},{"id":"https://openalex.org/keywords/serotonergic-system","display_name":"serotonergic system","score":0.7120000123977661},{"id":"https://openalex.org/keywords/eysenck-personality-inventory","display_name":"Eysenck Personality Inventory","score":0.6620000004768372},{"id":"https://openalex.org/keywords/neo-pi-r","display_name":"NEO-PI-R","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C2779583969","wikidata":"https://www.wikidata.org/wiki/Q423757","display_name":"Escitalopram","level":4,"score":0.7908177375793457},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.7461453080177307},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.6596627831459045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6359058618545532},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.477670282125473},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45991459488868713},{"id":"https://openalex.org/C94612546","wikidata":"https://www.wikidata.org/wiki/Q1540168","display_name":"Neuroticism","level":3,"score":0.45353010296821594},{"id":"https://openalex.org/C2779862289","wikidata":"https://www.wikidata.org/wiki/Q25098571","display_name":"First-degree relatives","level":3,"score":0.41945451498031616},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4174243211746216},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3670582175254822},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.3638108968734741},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.3501591980457306},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3440667390823364},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.30315691232681274},{"id":"https://openalex.org/C187288502","wikidata":"https://www.wikidata.org/wiki/Q641118","display_name":"Personality","level":2,"score":0.24970924854278564},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.2355092465877533},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.16418203711509705},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003718","descriptor_name":"Denmark","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010556","descriptor_name":"Personality Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011594","descriptor_name":"Psychometrics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015283","descriptor_name":"Citalopram","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015283","descriptor_name":"Citalopram","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057566","descriptor_name":"Self Report","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22459724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22459724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Danish medical journal","raw_type":"Journal Article"},{"id":"mag:2412475186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22459724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7096265509","https://openalex.org/W7019060603","https://openalex.org/W2023258470","https://openalex.org/W2109185125","https://openalex.org/W2135610944","https://openalex.org/W2238313629","https://openalex.org/W2922164744","https://openalex.org/W2006700386","https://openalex.org/W2007709610","https://openalex.org/W2912277372"],"abstract_inverted_index":{"The":[0,16,149,253,287],"mechanisms":[1],"of":[2,59,76,116,151,207,223,264,285,317,333,437],"action":[3],"for":[4,71,147,246,272],"selective":[5],"serotonin":[6],"re-uptake":[7],"in-hibitors":[8],"(SSRI)":[9],"in":[10,95,140,174,181,203,219,249,261,275,293,323,339,379,407,452],"depressed":[11,96],"patients":[12,186,208,224,232,457],"remain":[13],"widely":[14],"unknown.":[15],"serotonergic":[17,29],"neurotransmitter":[18,30],"system":[19,24,31],"and":[20,37,304,319,349,371,410,414,423,449],"the":[21,28,50,103,108,114,152,175,195,258,262,265,269,276,298,305,321,324,330,347,350,380,408,415,429,446],"hypothalamic-pituitary-adrenal":[22],"(HPA)":[23],"may":[25,90,200],"interact.":[26],"Further,":[27,192],"seems":[32],"closely":[33],"linked":[34],"to":[35,113,162,185,193,212,231,237,281,313,456],"personality":[36,53],"cognition.":[38],"It":[39,121],"is":[40,57,100,105,111],"not":[41,359,385,433],"known":[42],"if":[43,81,102,164],"SSRIs":[44,84,89,117],"have":[45],"a":[46,68,74,130,133,144,198,250],"direct":[47],"effect":[48,61,104,115,135,436],"on":[49,62,107,118,136,297,445],"HPA":[51],"system,":[52],"or":[54,110],"cognition":[55,326,382],"that":[56,197],"independent":[58],"their":[60],"depression.":[63,148],"Thus,":[64],"healthy":[65,141,182,204,220,228,453],"individuals":[66,142],"with":[67,83,129,143,167,187,209,225,233,365,388,391,443,458],"genetic":[69,145],"liability":[70,146],"depression":[72,420],"represent":[73],"group":[75],"particular":[77],"interest":[78],"when":[79],"investigating":[80],"intervention":[82,128,166,259,318],"affects":[85],"these":[86,92,137],"potential":[87,93,138],"biomarkers.":[88],"affect":[91,361],"biomarkers":[94,109,139],"patients,":[97],"but":[98],"it":[99],"unclear":[101],"directly":[106],"secondary":[112,288,411],"depressive":[119,189],"symptoms.":[120],"has":[122,132],"newer":[123],"been":[124],"tested":[125],"whether":[126,214],"an":[127,156,435],"SSRI":[131,168,199,215],"beneficial":[134],"aim":[150],"thesis":[153],"was":[154,257,329,384],"by":[155],"experimental":[157],"medicine":[158],"blinded":[159,251],"controlled":[160],"trial,":[161],"investigate":[163],"long-term":[165],"versus":[169,242],"placebo":[170,351,444],"decreases":[171],"cortisol":[172,274],"response":[173],"dexamethasone":[176],"corticotropin-releasing":[177],"hormone":[178],"(DEX-CRH)":[179],"test":[180,194,213,278,336],"first-degree":[183,205,221,229,454],"relatives":[184,206,222,230,455],"major":[188],"disorder":[190],"(MDD).":[191],"hypothesis":[196],"reduce":[201],"neuroticism":[202,295,448],"MDD.":[210,226,459],"Finally,":[211,376],"enhance":[216],"cognitive":[217,335,450],"function":[218,451],"Eighty":[227],"MDD":[234],"were":[235,290,403],"randomised":[236],"receive":[238],"escitalopram":[239,348,357,389,425,438],"10":[240,439],"mg":[241,440],"matching":[243],"pla-cebo":[244],"daily":[245,441],"four":[247,283,315],"weeks":[248,284,316],"trial.":[252],"primary":[254,409],"outcome":[255],"measure":[256],"difference":[260,345],"change":[263,292,322,378,406],"total":[266],"area":[267],"under":[268],"curve":[270],"(CorAUCtotal)":[271],"plasma":[273,424],"DEX-CRH":[277],"at":[279,311],"entry":[280,312],"after":[282,314],"intervention.":[286],"outcomes":[289],"a)":[291],"self-reported":[294,362],"scores":[296],"240-items":[299],"Revised":[300],"Neuroticism-Extroversion-Openness-Personality":[301],"Inventory":[302,309],"(NEO-PI-R)":[303],"101-items":[306],"Eysenck":[307],"Personality":[308],"(EPQ)":[310],"b)":[320],"general":[325,381],"score,":[327],"which":[328],"standardised":[331],"mean":[332,377],"13":[334],"measures.":[337],"Change":[338],"CorAUCtotal":[340],"showed":[341],"no":[342,399],"statically":[343],"significant":[344,401],"between":[346,405],"group,":[352],"p":[353],"=":[354,369,374,394],"0.47.":[355],"Fur-ther,":[356],"did":[358],"significantly":[360,386],"neu-roticism":[363],"compared":[364,390,442],"placebo,":[366,392],"NEO-PI-R":[367],"(p":[368,373,393],"0.09)":[370],"EPQ":[372],"0.73).":[375],"score":[383,421],"increased":[387],"0.37).":[395],"In":[396,427],"univariate":[397],"analyses,":[398],"statistically":[400],"correlations":[402],"found":[404],"outcomes,":[412],"respectively,":[413],"covariates":[416],"age,":[417],"sex,":[418],"Hamilton":[419],"17-items,":[422],"levels.":[426],"conclusion,":[428],"present":[430],"trial":[431],"does":[432],"support":[434],"HPA-axis,":[447]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}