{"id":"https://openalex.org/W2412447629","doi":null,"title":"[Regulation of antigen specific Th17 cells differentiation in experimental autoimmune uveitis].","display_name":"[Regulation of antigen specific Th17 cells differentiation in experimental autoimmune uveitis].","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W2412447629","mag":"2412447629","pmid":"https://pubmed.ncbi.nlm.nih.gov/22800421"},"language":"zh","primary_location":{"id":"pmid:22800421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22800421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"[Zhonghua yan ke za zhi] Chinese journal of ophthalmology","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012587352","display_name":"Hai-Ting Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Ting Chen","raw_affiliation_strings":["Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University , Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University , Beijing 100730, China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":["100730 \u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u540c\u4ec1\u533b\u9662\u5317\u4eac\u540c\u4ec1\u773c\u79d1\u4e2d\u5fc3\u5317\u4eac\u5e02\u773c\u79d1\u5b66\u4e0e\u89c6\u89c9\u79d1\u5b66\u91cd\u70b9\u5b9e\u9a8c\u5ba4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"100730 \u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u540c\u4ec1\u533b\u9662\u5317\u4eac\u540c\u4ec1\u773c\u79d1\u4e2d\u5fc3\u5317\u4eac\u5e02\u773c\u79d1\u5b66\u4e0e\u89c6\u89c9\u79d1\u5b66\u91cd\u70b9\u5b9e\u9a8c\u5ba4","institution_ids":["https://openalex.org/I1294606314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101400070","display_name":"Meng Zhao","orcid":"https://orcid.org/0000-0002-6253-7060","observed_orcids":["https://orcid.org/0000-0002-6253-7060","https://orcid.org/0009-0001-7267-400X"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Zhao","raw_affiliation_strings":["100730 \u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u540c\u4ec1\u533b\u9662\u5317\u4eac\u540c\u4ec1\u773c\u79d1\u4e2d\u5fc3\u5317\u4eac\u5e02\u773c\u79d1\u5b66\u4e0e\u89c6\u89c9\u79d1\u5b66\u91cd\u70b9\u5b9e\u9a8c\u5ba4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"100730 \u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u540c\u4ec1\u533b\u9662\u5317\u4eac\u540c\u4ec1\u773c\u79d1\u4e2d\u5fc3\u5317\u4eac\u5e02\u773c\u79d1\u5b66\u4e0e\u89c6\u89c9\u79d1\u5b66\u91cd\u70b9\u5b9e\u9a8c\u5ba4","institution_ids":["https://openalex.org/I1294606314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101494765","display_name":"Bin Hou","orcid":"https://orcid.org/0000-0002-1858-2294","observed_orcids":["https://orcid.org/0000-0002-1858-2294"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Hou","raw_affiliation_strings":["100730 \u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u540c\u4ec1\u533b\u9662\u5317\u4eac\u540c\u4ec1\u773c\u79d1\u4e2d\u5fc3\u5317\u4eac\u5e02\u773c\u79d1\u5b66\u4e0e\u89c6\u89c9\u79d1\u5b66\u91cd\u70b9\u5b9e\u9a8c\u5ba4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"100730 \u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u540c\u4ec1\u533b\u9662\u5317\u4eac\u540c\u4ec1\u773c\u79d1\u4e2d\u5fc3\u5317\u4eac\u5e02\u773c\u79d1\u5b66\u4e0e\u89c6\u89c9\u79d1\u5b66\u91cd\u70b9\u5b9e\u9a8c\u5ba4","institution_ids":["https://openalex.org/I1294606314"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2843,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66717868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"48","issue":"3","first_page":"234","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/experimental-autoimmune-uveitis","display_name":"experimental autoimmune uveitis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/th17-differentiation","display_name":"Th17 cell differentiation","score":0.925000011920929},{"id":"https://openalex.org/keywords/interphotoreceptor-retinoid-binding-protein","display_name":"interphotoreceptor retinoid-binding protein","score":0.8569999933242798},{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.6959999799728394},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9210000038146973},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9950000047683716},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.8740000128746033},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.875},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.7639999985694885},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.824999988079071},{"id":"https://openalex.org/keywords/il-27","display_name":"IL-27","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6473532915115356},{"id":"https://openalex.org/C47348012","wikidata":"https://www.wikidata.org/wiki/Q99486570","display_name":"Interleukin 17","level":3,"score":0.5858429670333862},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5733805298805237},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5304483771324158},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49753597378730774},{"id":"https://openalex.org/C74737994","wikidata":"https://www.wikidata.org/wiki/Q18031207","display_name":"RAR-related orphan receptor gamma","level":4,"score":0.45558980107307434},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4286614954471588},{"id":"https://openalex.org/C2781136212","wikidata":"https://www.wikidata.org/wiki/Q632518","display_name":"T helper cell","level":4,"score":0.4227762222290039},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3491642475128174},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3482922315597534},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33468097448349},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.333095908164978},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31617870926856995},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.2962653934955597},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2573363780975342}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058504","descriptor_name":"Th17 Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22800421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22800421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"[Zhonghua yan ke za zhi] Chinese journal of ophthalmology","raw_type":"English Abstract"},{"id":"mag:2412447629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22800421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2026041842","https://openalex.org/W2055026612","https://openalex.org/W3178659564","https://openalex.org/W7100607486","https://openalex.org/W1928412993","https://openalex.org/W2037402079","https://openalex.org/W1601703517","https://openalex.org/W1481332847","https://openalex.org/W1974663077","https://openalex.org/W3030912339"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,46,54,94,145,168,278,349,354],"regulation":[4],"of":[5,29,140,147,153,170,190,205,221,240,256,280,284,300,318,358],"antigen":[6,60,148],"specific":[7,149,334],"Th17":[8,100,135,150,154,225,241,281,285,319,335,359],"cells":[9,42,155,192,207,226,242,260,286,302,320],"differentiation":[10,146,227,279,336,355],"in":[11,51,53,172],"experimental":[12,128],"autoimmune":[13],"uveitis":[14],"(EAU).":[15],"METHODS:":[16],"A":[17],"randomized":[18],"controlled":[19],"trials":[20],"research.":[21],"EAU":[22],"model":[23],"was":[24],"made":[25],"through":[26],"subcutaneous":[27],"injection":[28],"interphotoreceptor":[30],"retinoid-binding":[31],"protein":[32],"(IRBP)":[33],"at":[34],"backs":[35],"and":[36,49,93,103,112,126,136,142,167,231,254,258,341,346,356],"bellies.":[37],"Mouse":[38],"splenic":[39],"CD4":[40],"T":[41],"were":[43,97,107,116],"collected":[44],"on":[45],"fourteenth":[47],"day":[48],"cultured":[50],"vitro":[52],"cell":[55,173],"culture":[56,174],"plates":[57],"containing":[58],"IRBP":[59,235],"for":[61,352],"72":[62],"hours":[63],"under":[64],"different":[65],"conditions:":[66],"control":[67],"group,":[68,70,72,74,78,84,86,238,316],"TGF-beta":[69,75,79,141,230],"IL-6":[71,77,81,143,345],"IL-23":[73,83,222,347],"+":[76,80,82],"IL-27":[85,276,362],"all":[87],"transretinoic":[88],"acid":[89],"(ATRA)":[90],"group.":[91],"Cells":[92],"clear":[95],"liquid":[96],"collected.":[98],"Then":[99],"cells,":[101,105],"IL-17":[102,171],"other":[104],"cytokines":[106],"assessed":[108],"by":[109,118,229],"flow":[110],"cytometry":[111],"ELISA.":[113],"All":[114],"data":[115],"analyzed":[117],"Student's":[119],"t":[120,269],"test.":[121],"RESULTS:":[122],"Flow":[123],"cytometric":[124],"detection":[125],"ELISA":[127],"results":[129],"showed:IRBP":[130],"polypeptide":[131,236],"alone":[132,237],"mainly":[133],"induced":[134,144,228],"Th1":[137,191,257,340],"response.":[138],"Addition":[139],"cells.":[151,282,343],"Percentage":[152,189,204,283],"increased":[156,176,243,303],"from":[157,177,194,209,244,288,304,322,339],"7.55%":[158,245,289,323],"to":[159,180,196,211,246,290,306,324],"13.08%":[160],"(t":[161,183,198,213,248,263,292,308,326],"=":[162,165,184,187,199,202,214,217,249,252,264,267,270,273,293,296,309,312,327,330],"-2.842,":[163],"P":[164,186,201,216,251,266,272,295,311,329],"0.048),":[166],"concentration":[169],"fluid":[175],"50.66":[178],"microg/L":[179,182],"164.12":[181],"-9.493,":[185],"0.009).":[188],"reduced":[193,208,261,287,321],"6.33%":[195],"3.43%":[197],"6.059,":[200],"0.004).":[203],"Treg":[206,301],"4.96%":[210,305],"1.52%":[212],"5.683,":[215],"0.005);":[218],"Furthermore,":[219],"addition":[220],"could":[223],"enhance":[224],"IL-6.":[232],"Compared":[233],"with":[234],"percentage":[239,255,299,317],"18.37%":[247],"-3.329,":[250],"0.029),":[253],"Th2":[259,342],"obviously":[262],"7.410,":[265],"0.002;":[268],"-3.863,":[271],"0.018).":[274],"While":[275],"suppressed":[277],"1.92%":[291],"4.425,":[294],"0.041),":[297],"while":[298],"9.98%":[307],"-5.073,":[310],"0.015);":[313],"In":[314],"ATRA":[315],"4.06%":[325],"2.163,":[328],"0.099).":[331],"CONCLUSIONS:":[332],"Antigen":[333],"is":[337],"distinct":[338],"TGF-beta,":[344],"are":[348],"factors":[350],"responsible":[351],"promoting":[353],"development":[357],"subset,":[360],"whereas":[361],"has":[363],"inhibitory":[364],"effects.":[365]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
