{"id":"https://openalex.org/W2412427328","doi":"https://doi.org/10.21037/jgo.2016.04.03","title":"Cost-effectiveness of precision medicine in gastrointestinal stromal tumor and gastric adenocarcinoma","display_name":"Cost-effectiveness of precision medicine in gastrointestinal stromal tumor and gastric adenocarcinoma","publication_year":2017,"publication_date":"2017-06-01","ids":{"openalex":"https://openalex.org/W2412427328","doi":"https://doi.org/10.21037/jgo.2016.04.03","mag":"2412427328","pmid":"https://pubmed.ncbi.nlm.nih.gov/28736638","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5506269"},"language":"en","primary_location":{"id":"doi:10.21037/jgo.2016.04.03","doi":"https://doi.org/10.21037/jgo.2016.04.03","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo.2016.04.03","pdf_url":"https://jgo.amegroups.com/article/viewFile/7609/pdf","source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jgo.amegroups.com/article/viewFile/7609/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036774794","display_name":"Simon Blechman Zeichner","orcid":"https://orcid.org/0000-0003-1953-6238","observed_orcids":["https://orcid.org/0000-0003-1953-6238"]},"institutions":[{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Simon B. Zeichner","raw_affiliation_strings":["Winship Cancer Institute at Emory University, Division of Hematology & Oncology, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute at Emory University, Division of Hematology & Oncology, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020242154","display_name":"Daniel A. Goldstein","orcid":"https://orcid.org/0000-0002-8082-9622","observed_orcids":["https://orcid.org/0000-0002-8082-9622"]},"institutions":[{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Daniel A. Goldstein","raw_affiliation_strings":["Davidoff Cancer Center, Rabin Medical Center, Petah Tikva 4941492, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Davidoff Cancer Center, Rabin Medical Center, Petah Tikva 4941492, Israel","institution_ids":["https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032615520","display_name":"Christine G. Kohn","orcid":"https://orcid.org/0000-0003-4372-2700","observed_orcids":["https://orcid.org/0000-0003-4372-2700"]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I192633058","display_name":"University of Saint Joseph","ror":"https://ror.org/05m5j6s60","country_code":"US","type":"education","lineage":["https://openalex.org/I192633058"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Kohn","raw_affiliation_strings":["University of Saint Joseph School of Pharmacy, Hartford Hospital Evidence-based Practice Center, Hartford, CT 06103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Saint Joseph School of Pharmacy, Hartford Hospital Evidence-based Practice Center, Hartford, CT 06103, USA","institution_ids":["https://openalex.org/I1302163369","https://openalex.org/I192633058"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082892912","display_name":"Christopher R. Flowers","orcid":"https://orcid.org/0000-0002-9524-3990","observed_orcids":["https://orcid.org/0000-0002-9524-3990"]},"institutions":[{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher R. Flowers","raw_affiliation_strings":["Winship Cancer Institute at Emory University, Division of Hematology & Oncology, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute at Emory University, Division of Hematology & Oncology, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I4390039307"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036774794"],"corresponding_institution_ids":["https://openalex.org/I4390039307"],"apc_list":null,"apc_paid":null,"fwci":1.2654,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.75485009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"3","first_page":"513","last_page":"523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.30809998512268066,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.1234000027179718,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.9350000023841858},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.996999979019165},{"id":"https://openalex.org/keywords/gastrointestinal-stromal-tumor","display_name":"gastrointestinal stromal tumor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/metastatic-gastric-adenocarcinoma","display_name":"metastatic gastric adenocarcinoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6859999895095825},{"id":"https://openalex.org/keywords/gene-sequencing","display_name":"gene sequencing","score":0.6819999814033508},{"id":"https://openalex.org/keywords/diagnostic-testing","display_name":"diagnostic testing","score":0.6230000257492065},{"id":"https://openalex.org/keywords/drug-acquisition-costs","display_name":"drug acquisition costs","score":0.6959999799728394},{"id":"https://openalex.org/keywords/patient-outcomes","display_name":"patient outcomes","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9612798690795898},{"id":"https://openalex.org/C2777007597","wikidata":"https://www.wikidata.org/wiki/Q16869243","display_name":"Stromal tumor","level":3,"score":0.524341881275177},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5190420746803284},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.48277416825294495},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.4633939862251282},{"id":"https://openalex.org/C2993283237","wikidata":"https://www.wikidata.org/wiki/Q189588","display_name":"Gastric adenocarcinoma","level":4,"score":0.4527845084667206},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3844505250453949},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3517521619796753},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23624494671821594},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20753997564315796}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21037/jgo.2016.04.03","doi":"https://doi.org/10.21037/jgo.2016.04.03","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo.2016.04.03","pdf_url":"https://jgo.amegroups.com/article/viewFile/7609/pdf","source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4362403","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5506269","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5506269","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5506269","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gastrointest Oncol","raw_type":"Text"},{"id":"pmid:28736638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28736638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/jgo.2016.04.03","doi":"https://doi.org/10.21037/jgo.2016.04.03","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo.2016.04.03","pdf_url":"https://jgo.amegroups.com/article/viewFile/7609/pdf","source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2412427328.pdf","grobid_xml":"https://content.openalex.org/works/W2412427328.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W656919145","https://openalex.org/W1742083806","https://openalex.org/W1921489273","https://openalex.org/W1970687736","https://openalex.org/W1980323844","https://openalex.org/W1982984751","https://openalex.org/W1987009448","https://openalex.org/W1993494638","https://openalex.org/W1995827154","https://openalex.org/W1998758456","https://openalex.org/W2000998080","https://openalex.org/W2005697460","https://openalex.org/W2036977598","https://openalex.org/W2037471181","https://openalex.org/W2042929108","https://openalex.org/W2049912688","https://openalex.org/W2050056063","https://openalex.org/W2053580566","https://openalex.org/W2061055806","https://openalex.org/W2068079378","https://openalex.org/W2071056007","https://openalex.org/W2072098827","https://openalex.org/W2075657881","https://openalex.org/W2076516630","https://openalex.org/W2078058278","https://openalex.org/W2091448280","https://openalex.org/W2095974037","https://openalex.org/W2097988373","https://openalex.org/W2100439220","https://openalex.org/W2101986793","https://openalex.org/W2102769930","https://openalex.org/W2104759721","https://openalex.org/W2104991120","https://openalex.org/W2110444464","https://openalex.org/W2110577005","https://openalex.org/W2112816082","https://openalex.org/W2113720307","https://openalex.org/W2115175878","https://openalex.org/W2115504770","https://openalex.org/W2116922255","https://openalex.org/W2118897332","https://openalex.org/W2126042521","https://openalex.org/W2128518955","https://openalex.org/W2130320283","https://openalex.org/W2131887171","https://openalex.org/W2132668126","https://openalex.org/W2137144853","https://openalex.org/W2139511378","https://openalex.org/W2140626630","https://openalex.org/W2150501295","https://openalex.org/W2150878386","https://openalex.org/W2159967578","https://openalex.org/W2166199281","https://openalex.org/W2170488412","https://openalex.org/W2170651337","https://openalex.org/W2171620774","https://openalex.org/W2194735827","https://openalex.org/W2220679976","https://openalex.org/W2235523093","https://openalex.org/W2240503289","https://openalex.org/W2319883326","https://openalex.org/W2333563174","https://openalex.org/W2336417567","https://openalex.org/W2410407118","https://openalex.org/W2422179176","https://openalex.org/W3089528479","https://openalex.org/W4249003418","https://openalex.org/W4254130498","https://openalex.org/W4387993641","https://openalex.org/W6663166422","https://openalex.org/W7075729444"],"related_works":["https://openalex.org/W3089249991","https://openalex.org/W2270857651","https://openalex.org/W4387785956","https://openalex.org/W2347121652","https://openalex.org/W4205435680","https://openalex.org/W2623014943","https://openalex.org/W2611041238","https://openalex.org/W2514742214","https://openalex.org/W2993633535","https://openalex.org/W3198633373"],"abstract_inverted_index":{"Over":[0],"the":[1,6,15,36,42,56,109,114,130],"past":[2],"20":[3],"years,":[4],"with":[5,60,97,117,138],"incorporation":[7],"of":[8,17,39,58],"genetic":[9],"sequencing":[10],"and":[11,22,30,64,81,90,135,142,147],"improved":[12],"understanding":[13],"regarding":[14,133],"mechanisms":[16],"cancer":[18],"growth/metastasis,":[19],"novel":[20],"targets":[21],"their":[23],"associated":[24,82,96,116,137],"treatments":[25,83],"have":[26,120],"emerged":[27],"in":[28,41,55,84,105,112],"oncology":[29],"are":[31,52,88],"now":[32],"regularly":[33],"incorporated":[34],"into":[35],"clinical":[37],"care":[38],"patients":[40,59],"US.":[43],"Novel,":[44],"more":[45],"tumor-specific,":[46],"non-chemotherapy":[47],"agents,":[48],"including":[49],"agents":[50,115],"that":[51],"commonly":[53],"used":[54],"treatment":[57,73,143],"gastric":[61],"adenocarcinoma":[62],"(GA)":[63],"gastrointestinal":[65],"stromal":[66],"tumor":[67],"(GIST),":[68],"fall":[69],"under":[70],"a":[71],"broader":[72],"strategy,":[74],"termed":[75],"\"precision":[76],"medicine\".":[77],"While":[78],"diagnostic":[79],"testing":[80],"metastatic":[85],"GA":[86,146],"(mGA)":[87],"costly":[89],"may":[91],"produce":[92,102],"marginal":[93],"benefit,":[94],"those":[95],"GIST,":[98],"despite":[99],"being":[100],"costly,":[101],"significant":[103,110],"improvements":[104],"patient":[106],"outcomes.":[107],"Despite":[108],"difference":[111],"impact,":[113],"these":[118],"cancers":[119],"similar":[121],"acquisition":[122],"costs.":[123],"In":[124],"this":[125],"paper,":[126],"we":[127],"will":[128],"review":[129],"current":[131],"literature":[132],"cost":[134],"cost-effectiveness":[136],"precision":[139],"medicine":[140],"diagnosis":[141],"strategies":[144],"for":[145],"GIST.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}