{"id":"https://openalex.org/W24123876","doi":null,"title":"Long-term alloxan diabetes in the rat. Study of mesangial cell morphology by serial biopsies.","display_name":"Long-term alloxan diabetes in the rat. Study of mesangial cell morphology by serial biopsies.","publication_year":1976,"publication_date":"1976-01-01","ids":{"openalex":"https://openalex.org/W24123876","mag":"24123876","pmid":"https://pubmed.ncbi.nlm.nih.gov/194206"},"language":"en","primary_location":{"id":"pmid:194206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/194206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathologia Europaea","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071338888","display_name":"Aurora Anjo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Anjo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"E Couturier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Couturier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0029098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"4","first_page":"239","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.09839999675750732,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alloxan-induced-diabetes","display_name":"alloxan-induced diabetes","score":0.9769999980926514},{"id":"https://openalex.org/keywords/experimental-diabetes","display_name":"experimental diabetes","score":0.6159999966621399},{"id":"https://openalex.org/keywords/mesangial-cells","display_name":"mesangial cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/glomerulus","display_name":"glomeruli","score":0.9089999794960022},{"id":"https://openalex.org/keywords/dense-bodies","display_name":"dense bodies","score":0.6119999885559082},{"id":"https://openalex.org/keywords/lysosomal-system","display_name":"lysosomal system","score":0.625},{"id":"https://openalex.org/keywords/silver-staining","display_name":"silver staining","score":0.7070000171661377},{"id":"https://openalex.org/keywords/acid-phosphatase","display_name":"acid phosphatase","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2778305430","wikidata":"https://www.wikidata.org/wiki/Q26261754","display_name":"Glomerulus","level":3,"score":0.7277296781539917},{"id":"https://openalex.org/C2779131090","wikidata":"https://www.wikidata.org/wiki/Q3331086","display_name":"Mesangial cell","level":3,"score":0.680806040763855},{"id":"https://openalex.org/C2781005915","wikidata":"https://www.wikidata.org/wiki/Q417701","display_name":"Alloxan","level":3,"score":0.6526092886924744},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6051367521286011},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.5793887972831726},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5517725944519043},{"id":"https://openalex.org/C3018920779","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Renal glomerulus","level":4,"score":0.5105425119400024},{"id":"https://openalex.org/C2776115139","wikidata":"https://www.wikidata.org/wiki/Q1753456","display_name":"Glomerular basement membrane","level":4,"score":0.5074867606163025},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.47933468222618103},{"id":"https://openalex.org/C21547065","wikidata":"https://www.wikidata.org/wiki/Q418243","display_name":"Acid phosphatase","level":3,"score":0.4720474183559418},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4671812653541565},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4500121474266052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4294321835041046},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3819804787635803},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3440542221069336},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33215975761413574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3090175986289978},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.2754059433937073},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.27219530940055847},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1160837709903717},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07586613297462463},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07536032795906067}],"mesh":[{"descriptor_ui":"D000135","descriptor_name":"Acid Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:194206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/194206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathologia Europaea","raw_type":"Journal Article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/182000","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/182000","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PATH.EUROP. 11 (4","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:24123876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/194206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1559742681","https://openalex.org/W1829137581","https://openalex.org/W1971835681","https://openalex.org/W1976298213","https://openalex.org/W1985252531","https://openalex.org/W1987824870","https://openalex.org/W1989590409","https://openalex.org/W1996803437","https://openalex.org/W1996941416","https://openalex.org/W1998228863","https://openalex.org/W2017173296","https://openalex.org/W2018643387","https://openalex.org/W2021341670","https://openalex.org/W2022629430","https://openalex.org/W2026947381","https://openalex.org/W2047498240","https://openalex.org/W2059145105","https://openalex.org/W2072506631","https://openalex.org/W2074167964","https://openalex.org/W2080187462","https://openalex.org/W2091376022","https://openalex.org/W2092276132","https://openalex.org/W2101269797","https://openalex.org/W2106806319","https://openalex.org/W2107126369","https://openalex.org/W2107277218","https://openalex.org/W2108244474","https://openalex.org/W2110526616","https://openalex.org/W2115558586","https://openalex.org/W2116753165","https://openalex.org/W2123352533","https://openalex.org/W2127174421","https://openalex.org/W2137575965","https://openalex.org/W2138033133","https://openalex.org/W2138196920","https://openalex.org/W2145138789","https://openalex.org/W2408906671","https://openalex.org/W2977931116","https://openalex.org/W6629874611"],"related_works":["https://openalex.org/W1892036726","https://openalex.org/W2139022340","https://openalex.org/W2162992169","https://openalex.org/W1847052733","https://openalex.org/W1456629988","https://openalex.org/W2059954696","https://openalex.org/W2086254494","https://openalex.org/W1948137015","https://openalex.org/W4297944749","https://openalex.org/W1811678469"],"abstract_inverted_index":{"Experimental":[0],"diabetes":[1],"in":[2,15,51,56,67,73,80,109,136],"the":[3,37,52,60,68,74,81,96,110,113,126,130,146,152,160,164],"rat":[4],"was":[5,40,134],"induced":[6],"by":[7,42],"alloxan":[8],"(40":[9],"mg/kg":[10],"body":[11],"weight)":[12],"and":[13,55,76],"resulted":[14],"permanent":[16],"hyperglycaemia":[17],"(mean":[18],"glycaemia:":[19],"403.0":[20],"mg/100":[21],"ml).":[22],"The":[23,33],"animals":[24,54],"were":[25],"left":[26],"untreated":[27],"for":[28],"more":[29],"than":[30],"16":[31],"months.":[32],"mesangial":[34,89],"cell":[35],"of":[36,59,88,118,125,163],"renal":[38],"glomerulus":[39],"studied":[41],"serial":[43],"biopsies":[44],"performed":[45],"each":[46],"month":[47],"under":[48],"light":[49],"anaesthesia":[50],"diabetic":[53,140],"normal":[57],"controls":[58],"same":[61],"age.":[62],"Large":[63],"dense":[64,93,114,148,165],"bodies":[65,115,149,166],"appeared":[66],"cytoplasm":[69],"after":[70,77],"3":[71],"months":[72,79],"diabetics":[75],"10":[78],"controls.":[82],"With":[83],"time,":[84],"a":[85],"larger":[86],"number":[87],"cells":[90],"contained":[91],"these":[92],"bodies.":[94],"At":[95],"end":[97],"stage":[98],"they":[99,122],"seem":[100],"to":[101,151],"be":[102],"mainly":[103],"lipidic.":[104],"When":[105],"NO3Ag":[106],"is":[107,167],"given":[108],"drinking":[111],"water":[112],"accumulate":[116],"particles":[117],"silver,":[119],"suggesting":[120],"that":[121,145],"contain":[123],"fragments":[124],"basement":[127],"membrane.":[128],"While":[129],"acid":[131],"phosphatase":[132],"reaction":[133],"negative":[135],"biopsy":[137],"specimens":[138],"from":[139],"animals,":[141],"it":[142],"remains":[143],"possible":[144],"large":[147],"belong":[150],"lysosomial":[153],"system.":[154],"This":[155],"point,":[156],"as":[157,159],"well":[158],"pathologic":[161],"significance":[162],"currently":[168],"investigated.":[169]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}