{"id":"https://openalex.org/W2412379064","doi":"https://doi.org/10.1042/bj2730219","title":"Changes in the mechanism of Ca2+ mobilization during the differentiation of BC3H1 muscle cells","display_name":"Changes in the mechanism of Ca2+ mobilization during the differentiation of BC3H1 muscle cells","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2412379064","doi":"https://doi.org/10.1042/bj2730219","mag":"2412379064","pmid":"https://pubmed.ncbi.nlm.nih.gov/1989585","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1149902"},"language":"en","primary_location":{"id":"doi:10.1042/bj2730219","doi":"https://doi.org/10.1042/bj2730219","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2730219","pdf_url":"https://portlandpress.com/biochemj/article-pdf/273/1/219/601872/bj2730219.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/273/1/219/601872/bj2730219.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035800550","display_name":"Humbert DE SMEDT","orcid":"https://orcid.org/0000-0002-6459-603X","observed_orcids":["https://orcid.org/0000-0002-6459-603X"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"H De Smedt","raw_affiliation_strings":["Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082879421","display_name":"Jan B. Parys","orcid":"https://orcid.org/0000-0002-3591-4967","observed_orcids":["https://orcid.org/0000-0002-3591-4967"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J B Parys","raw_affiliation_strings":["Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032340086","display_name":"Bernard Himpens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"B Himpens","raw_affiliation_strings":["Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029742854","display_name":"Ludwig Missiaen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"L Missiaen","raw_affiliation_strings":["Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060490990","display_name":"Roger Borghgraef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"R Borghgraef","raw_affiliation_strings":["Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":null,"apc_paid":null,"fwci":3.0392,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.92483597,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"273","issue":"1","first_page":"219","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.08640000224113464,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.07339999824762344,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.9539999961853027},{"id":"https://openalex.org/keywords/muscle-cell-differentiation","display_name":"muscle cell differentiation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"inositol trisphosphate","score":0.8040000200271606},{"id":"https://openalex.org/keywords/intracellular-calcium-concentration","display_name":"intracellular calcium concentration","score":0.7379999756813049},{"id":"https://openalex.org/keywords/histamine-response","display_name":"histamine response","score":0.765999972820282},{"id":"https://openalex.org/keywords/growth-promotion","display_name":"growth promotion","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6982659697532654},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6557143926620483},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.6349304914474487},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5470120310783386},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5266509056091309},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.49904799461364746},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4693140983581543},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4627054035663605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4101073741912842},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.357451856136322},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19935697317123413},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.056502968072891235}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj2730219","doi":"https://doi.org/10.1042/bj2730219","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2730219","pdf_url":"https://portlandpress.com/biochemj/article-pdf/273/1/219/601872/bj2730219.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1149902","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1149902","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:1989585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1989585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj2730219","doi":"https://doi.org/10.1042/bj2730219","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2730219","pdf_url":"https://portlandpress.com/biochemj/article-pdf/273/1/219/601872/bj2730219.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2412379064.pdf","grobid_xml":"https://content.openalex.org/works/W2412379064.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W28762819","https://openalex.org/W71582486","https://openalex.org/W1495187283","https://openalex.org/W1496519351","https://openalex.org/W1508947443","https://openalex.org/W1509427554","https://openalex.org/W1516070458","https://openalex.org/W1532284082","https://openalex.org/W1561980328","https://openalex.org/W1564829038","https://openalex.org/W1564957024","https://openalex.org/W1575979011","https://openalex.org/W1580787869","https://openalex.org/W1582789812","https://openalex.org/W1593774413","https://openalex.org/W1596082331","https://openalex.org/W1605124928","https://openalex.org/W1663123254","https://openalex.org/W1740533879","https://openalex.org/W1775749144","https://openalex.org/W1800167367","https://openalex.org/W1928258718","https://openalex.org/W1945703861","https://openalex.org/W1956859188","https://openalex.org/W1971936465","https://openalex.org/W1972484465","https://openalex.org/W1981941073","https://openalex.org/W1994212926","https://openalex.org/W1995429206","https://openalex.org/W2001498679","https://openalex.org/W2017139762","https://openalex.org/W2032363260","https://openalex.org/W2061440119","https://openalex.org/W2062152852","https://openalex.org/W2079250143","https://openalex.org/W2092224962","https://openalex.org/W2128797099","https://openalex.org/W2129310997","https://openalex.org/W2138310843","https://openalex.org/W2161244301","https://openalex.org/W6602549760","https://openalex.org/W6629138492","https://openalex.org/W6632676472","https://openalex.org/W6815926605"],"related_works":["https://openalex.org/W2400241614","https://openalex.org/W2345222283","https://openalex.org/W2066394289","https://openalex.org/W2038588350","https://openalex.org/W2083509475","https://openalex.org/W2162451481","https://openalex.org/W2421538341","https://openalex.org/W4280547489","https://openalex.org/W7018292398","https://openalex.org/W2296622290"],"abstract_inverted_index":{"Ca2+":[0,25,36,50,67,116],"sequestration":[1],"and":[2,28,41,84],"release":[3],"in":[4,69,105],"BC3H1":[5,72,106],"muscle":[6,92,103],"cells":[7,82,89],"is":[8],"strongly":[9],"dependent":[10],"on":[11],"the":[12,23,35,48,65,78,85,99,102,113],"stage":[13],"of":[14,22,47,59,80,87,101,112],"differentiation.":[15,94],"In":[16,32],"proliferating":[17],"cells,":[18,34,73],"more":[19],"than":[20],"90%":[21],"sequestered":[24,49],"was":[26,30,38,42,51,75],"Ins(1,4,5)P3-sensitive":[27],"25%":[29],"caffeine-sensitive.":[31,52],"differentiated":[33],"accumulation":[37],"5-fold":[39],"higher":[40],"InsP3-insensitive,":[43],"but":[44],"about":[45],"60%":[46],"These":[53,95],"changes":[54],"were":[55],"reversible":[56],"upon":[57],"addition":[58],"growth":[60],"stimuli.":[61],"Similarly,":[62],"by":[63],"measuring":[64],"intracellular":[66],"concentration":[68],"single":[70],"intact":[71],"it":[74],"found":[76],"that":[77,98],"number":[79,86],"histamine-responsive":[81],"decreased":[83],"caffeine-responsive":[88],"increased":[90],"during":[91],"cell":[93],"data":[96],"indicate":[97],"development":[100],"phenotype":[104],"myoblasts":[107],"induces":[108],"a":[109],"major":[110],"rearrangement":[111],"mechanisms":[114],"for":[115],"mobilization.":[117]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}