{"id":"https://openalex.org/W2412349392","doi":null,"title":"Estrogen receptor and binding site for estramustine in metastatic malignant melanoma.","display_name":"Estrogen receptor and binding site for estramustine in metastatic malignant melanoma.","publication_year":1987,"publication_date":"1987-07-01","ids":{"openalex":"https://openalex.org/W2412349392","mag":"2412349392","pmid":"https://pubmed.ncbi.nlm.nih.gov/3314674"},"language":"en","primary_location":{"id":"pmid:3314674","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3314674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044494492","display_name":"M\u00e5rten Fern\u00f6","orcid":"https://orcid.org/0000-0003-2220-1236","observed_orcids":["https://orcid.org/0000-0003-2220-1236"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"M Fern\u00f6","raw_affiliation_strings":["Department of Oncology, University Hospital, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061851445","display_name":"\u00c5ke Borg","orcid":"https://orcid.org/0009-0009-2332-3228","observed_orcids":["https://orcid.org/0009-0009-2332-3228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Borg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102978610","display_name":"Christian Ingvar","orcid":"https://orcid.org/0000-0002-7721-4619","observed_orcids":["https://orcid.org/0000-0002-7721-4619"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Ingvar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111967620","display_name":"P.-E. J\u00f6nsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P E J\u00f6nsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6907,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.72692786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":"4B","first_page":"741","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.04540000110864639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/estramustine","display_name":"estramustine","score":0.7440000176429749},{"id":"https://openalex.org/keywords/estramustine-phosphate","display_name":"estramustine phosphate","score":0.9129999876022339},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.7599999904632568},{"id":"https://openalex.org/keywords/estradiol-binding","display_name":"estradiol binding","score":0.6700000166893005},{"id":"https://openalex.org/keywords/isoelectric-focusing","display_name":"isoelectric focusing","score":0.7300000190734863},{"id":"https://openalex.org/keywords/enzyme-immunoassay","display_name":"enzyme immunoassay","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C2780201970","wikidata":"https://www.wikidata.org/wiki/Q412939","display_name":"Estramustine","level":5,"score":0.9009478092193604},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.505446195602417},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4999821186065674},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.48547127842903137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4810538589954376},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.448970764875412},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.447148859500885},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4450129568576813},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4359566271305084},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.403475284576416},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36092492938041687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.344234824180603},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.24168947339057922},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.21321046352386475},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1478835642337799},{"id":"https://openalex.org/C2994223898","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate disease","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004961","descriptor_name":"Estramustine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009588","descriptor_name":"Nitrogen Mustard Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:3314674","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3314674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2412349392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3314674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2018841796","https://openalex.org/W2062626332","https://openalex.org/W2468983425","https://openalex.org/W2030411293","https://openalex.org/W1985925208","https://openalex.org/W2030998987","https://openalex.org/W1997963564","https://openalex.org/W2417386498","https://openalex.org/W1966003642","https://openalex.org/W2323804745"],"abstract_inverted_index":{"Enzyme":[0],"immuno":[1],"assay":[2,54],"(EIA)":[3],"of":[4,12,34,57,75,104,121,133,140,146],"estrogen":[5],"receptor":[6],"(ER)":[7],"has":[8,97],"confirmed":[9],"the":[10,51,65,73,118,128,138,143],"results":[11,77],"earlier":[13],"investigations":[14],"using":[15,46],"steroid":[16,52],"binding":[17,53,91,94,135],"techniques,":[18],"namely":[19],"that":[20],"ER":[21,39,82],"is":[22],"present":[23],"at":[24,80],"very":[25],"low":[26,81],"concentrations":[27],"in":[28,72,100,110,137,153,157],"samples":[29,36,60,101],"from":[30,88,102],"metastatic":[31,154],"melanoma.":[32],"Thirty-four":[33],"61":[35,59],"(56%)":[37],"were":[38,55],"positive":[40],"with":[41,108,116,159],"EIA.":[42],"The":[43,62],"corresponding":[44],"figures":[45],"isoelectric":[47],"focusing":[48],"(IF)":[49],"for":[50,78],"16":[56],"these":[58],"(26%).":[61],"difference":[63],"between":[64],"methods":[66],"may":[67],"be":[68,151],"due":[69],"to":[70,86,127],"difficulties":[71],"interpretation":[74],"analytical":[76],"IF":[79,109],"concentration":[83],"levels":[84],"or":[85],"interference":[87],"other":[89],"3H-estradiol":[90],"components.":[92],"Estramustine":[93,113],"site":[95],"(EMBS)":[96],"been":[98],"found":[99],"15":[103],"77":[105],"patients":[106],"(20%)":[107],"polyacrylamide":[111],"gels.":[112],"is,":[114],"together":[115],"estramustine,":[117],"cytotoxic":[119],"metabolite":[120],"estramustine":[122,134,147],"phosphate":[123,148],"(Estracyt).":[124],"In":[125],"analogy":[126],"previously":[129],"suggested":[130],"therapeutic":[131],"significance":[132],"protein":[136],"treatment":[139],"prostatic":[141],"cancer,":[142],"clinical":[144],"importance":[145],"should":[149],"also":[150],"studied":[152],"malignant":[155],"melanoma":[156],"correlation":[158],"EMBS":[160],"status.":[161]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}