{"id":"https://openalex.org/W2411344780","doi":null,"title":"Decreased expression of long non-coding RNA MEG3 acts as a potential predictor biomarker in progression and poor prognosis of osteosarcoma.","display_name":"Decreased expression of long non-coding RNA MEG3 acts as a potential predictor biomarker in progression and poor prognosis of osteosarcoma.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2411344780","mag":"2411344780","pmid":"https://pubmed.ncbi.nlm.nih.gov/26823857","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4713643"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4713643","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4713643","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4713643","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113760318","display_name":"Zhi-Zhong Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152095","display_name":"Xinxiang Central Hospital","ror":"https://ror.org/006zn6z18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152095"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Zhong Tian","raw_affiliation_strings":["Department of Orthopedics, Xinxiang Central Hospital Xinxiang 453000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xinxiang Central Hospital Xinxiang 453000, China","institution_ids":["https://openalex.org/I4210152095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064255618","display_name":"Xinjun Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152095","display_name":"Xinxiang Central Hospital","ror":"https://ror.org/006zn6z18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152095"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin-Jun Guo","raw_affiliation_strings":["Department of Orthopedics, Xinxiang Central Hospital Xinxiang 453000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xinxiang Central Hospital Xinxiang 453000, China","institution_ids":["https://openalex.org/I4210152095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104102074","display_name":"Yongming Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152095","display_name":"Xinxiang Central Hospital","ror":"https://ror.org/006zn6z18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152095"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong-Ming Zhao","raw_affiliation_strings":["Department of Orthopedics, Xinxiang Central Hospital Xinxiang 453000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xinxiang Central Hospital Xinxiang 453000, China","institution_ids":["https://openalex.org/I4210152095"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101650825","display_name":"Yuan Fang","orcid":"https://orcid.org/0000-0002-2801-2121","observed_orcids":["https://orcid.org/0000-0002-2801-2121"]},"institutions":[{"id":"https://openalex.org/I4210152095","display_name":"Xinxiang Central Hospital","ror":"https://ror.org/006zn6z18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152095"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Fang","raw_affiliation_strings":["Department of Orthopedics, Xinxiang Central Hospital Xinxiang 453000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xinxiang Central Hospital Xinxiang 453000, China","institution_ids":["https://openalex.org/I4210152095"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210152095"],"apc_list":null,"apc_paid":null,"fwci":3.9366,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.95325892,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"8","issue":"11","first_page":"15138","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lncrna-meg3","display_name":"lncRNA MEG3","score":0.875},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9300000071525574},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.984000027179718},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8920000195503235},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/clinical-stage","display_name":"clinical stage","score":0.890999972820282},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7409999966621399},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C2781369401","wikidata":"https://www.wikidata.org/wiki/Q18041809","display_name":"MEG3","level":5,"score":0.8480299711227417},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.8341851234436035},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.7092484831809998},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6347653269767761},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5969683527946472},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5493837594985962},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5105513334274292},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4838649034500122},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.44343000650405884},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.433590292930603},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.429257869720459},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42305296659469604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3963209390640259},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3876919150352478},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2995832562446594},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11496323347091675},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04781290888786316},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4713643","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4713643","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:26823857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26823857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"mag:2411344780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26823857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4713643","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4713643","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W181426613","https://openalex.org/W617617441","https://openalex.org/W1435045704","https://openalex.org/W1864729394","https://openalex.org/W1988325237","https://openalex.org/W2003544524","https://openalex.org/W2050114212","https://openalex.org/W2053740048","https://openalex.org/W2066815559","https://openalex.org/W2071271349","https://openalex.org/W2083239828","https://openalex.org/W2087377443","https://openalex.org/W2091161969","https://openalex.org/W2099176640","https://openalex.org/W2106787323","https://openalex.org/W2106861653","https://openalex.org/W2124050695","https://openalex.org/W2146573461","https://openalex.org/W2150695488"],"related_works":["https://openalex.org/W2770520463","https://openalex.org/W2793246190","https://openalex.org/W2782803783","https://openalex.org/W2896541536","https://openalex.org/W2893418727","https://openalex.org/W7061303196","https://openalex.org/W2588600997","https://openalex.org/W2767867596","https://openalex.org/W3134122255","https://openalex.org/W2599972203"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Long":[1],"non-coding":[2],"RNA":[3],"MEG3":[4,22,39,92,108,126,166,176],"(lncRNA":[5],"MEG3)":[6],"has":[7],"been":[8],"showed":[9,87,120],"to":[10,156],"involve":[11],"in":[12,40,55,96],"a":[13,65,129,179],"variety":[14],"of":[15,28,37,81,90,106,143,159,164,173,186],"cancers.":[16],"However,":[17],"the":[18,26,61],"association":[19],"between":[20],"lncRNA":[21,38,91,107,125,144,165],"expression":[23,35,89,105,127,142],"level":[24],"and":[25,43,64,78,114,149,184],"prognosis":[27,185],"osteosarcoma":[29,41,97,160],"is":[30],"still":[31],"unclear.":[32],"METHODS:":[33],"The":[34,104],"levels":[36],"tissues":[42,46,98],"adjacent":[44,101],"non-tumor":[45,102],"were":[47,58,152],"detected":[48],"using":[49,60],"quantitative":[50],"real-time":[51],"PCR":[52],"(qRT-PCR).":[53],"Differences":[54],"patient":[56],"survival":[57,132,158,172],"determined":[59],"Kaplan-Meier":[62,118],"method":[63],"log-rank":[66],"test.":[67],"A":[68],"Cox":[69],"proportional":[70],"hazards":[71],"regression":[72],"analysis":[73,119,138],"was":[74,93,109,167],"used":[75],"for":[76,182],"univariate":[77],"multivariate":[79,137],"analyses":[80],"prognostic":[82],"values.":[83],"RESULTS:":[84],"Our":[85],"findings":[86],"that":[88,121,140],"clearly":[94],"lower":[95],"compared":[99],"with":[100,111,123,169],"tissues.":[103],"associated":[110,168],"clinical":[112,147],"stage":[113,148],"distant":[115,150],"metastasis":[116,151],"(P<0.05).":[117],"patients":[122],"low":[124],"had":[128],"shorter":[130],"overall":[131,157,171],"(log-rank":[133],"test,":[134],"P<0.05).":[135],"Furthermore,":[136],"revealed":[139],"decreased":[141],"MEG3,":[145],"advanced":[146],"all":[153],"independent":[154],"predictors":[155],"patients.":[161],"CONCLUSIONS:":[162],"Downregulation":[163],"poor":[170],"osteosarcoma.":[174,187],"LncRNA":[175],"could":[177],"be":[178],"useful":[180],"biomarker":[181],"progression":[183]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
