{"id":"https://openalex.org/W2411202201","doi":null,"title":"Watery diarrhea in a patient with myasthenia gravis, thymoma, and immunodeficiency.","display_name":"Watery diarrhea in a patient with myasthenia gravis, thymoma, and immunodeficiency.","publication_year":1985,"publication_date":"1985-11-01","ids":{"openalex":"https://openalex.org/W2411202201","mag":"2411202201","pmid":"https://pubmed.ncbi.nlm.nih.gov/2996329"},"language":"en","primary_location":{"id":"pmid:2996329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2996329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053160478","display_name":"Sanjeev Kumar Gupta","orcid":"https://orcid.org/0000-0002-5818-7280","observed_orcids":["https://orcid.org/0000-0002-5818-7280"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Gupta","raw_affiliation_strings":["\u2020Imperial College Healthcare NHS Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Imperial College Healthcare NHS Trust","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113740587","display_name":"Sethna H. Saverymuttu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S H Saverymuttu","raw_affiliation_strings":["\u2020Imperial College Healthcare NHS Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Imperial College Healthcare NHS Trust","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026902884","display_name":"J. Simon R. Gibbs","orcid":"https://orcid.org/0000-0001-6147-9252","observed_orcids":["https://orcid.org/0000-0001-6147-9252"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J S Gibbs","raw_affiliation_strings":["\u2020Imperial College Healthcare NHS Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Imperial College Healthcare NHS Trust","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111787010","display_name":"D. J. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D J Evans","raw_affiliation_strings":["\u2020Imperial College Healthcare NHS Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Imperial College Healthcare NHS Trust","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113588603","display_name":"Humphrey J.F. Hodgson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H J Hodgson","raw_affiliation_strings":["\u2020Imperial College Healthcare NHS Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Imperial College Healthcare NHS Trust","institution_ids":["https://openalex.org/I153355300"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I153355300"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.28874122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"80","issue":"11","first_page":"877","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.20360000431537628,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/watery-diarrhea","display_name":"watery diarrhea","score":0.9599999785423279},{"id":"https://openalex.org/keywords/myasthenia-gravis","display_name":"myasthenia gravis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thymoma","display_name":"thymoma","score":1.0},{"id":"https://openalex.org/keywords/hypogammaglobulinemia","display_name":"hypogammaglobulinemia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cytomegalovirus-infection","display_name":"cytomegalovirus infection","score":0.8569999933242798},{"id":"https://openalex.org/keywords/duodenal-ulcer","display_name":"duodenal ulcer","score":0.7379999756813049},{"id":"https://openalex.org/keywords/ileal-ulceration","display_name":"ileal ulcer","score":0.7879999876022339},{"id":"https://openalex.org/keywords/villous-atrophy","display_name":"villous atrophy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/small-intestine-inflammation","display_name":"small bowel inflammation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/bronchopneumonia","display_name":"bronchopneumonia","score":0.902999997138977},{"id":"https://openalex.org/keywords/herpes-simplex-virus-infection","display_name":"herpes simplex","score":0.8529999852180481},{"id":"https://openalex.org/keywords/invasive-candidiasis","display_name":"invasive candidiasis","score":0.996999979019165},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.7979999780654907},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9257005453109741},{"id":"https://openalex.org/C2777805810","wikidata":"https://www.wikidata.org/wiki/Q1047559","display_name":"Hypogammaglobulinemia","level":3,"score":0.8598108291625977},{"id":"https://openalex.org/C2779159893","wikidata":"https://www.wikidata.org/wiki/Q1429863","display_name":"Thymoma","level":2,"score":0.7346591949462891},{"id":"https://openalex.org/C2781107259","wikidata":"https://www.wikidata.org/wiki/Q5508364","display_name":"Fulminant","level":2,"score":0.6835882067680359},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.6336907744407654},{"id":"https://openalex.org/C2993432164","wikidata":"https://www.wikidata.org/wiki/Q868506","display_name":"Villous atrophy","level":4,"score":0.5750380754470825},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.5730408430099487},{"id":"https://openalex.org/C2778105408","wikidata":"https://www.wikidata.org/wiki/Q8285","display_name":"Myasthenia gravis","level":2,"score":0.5600190758705139},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.5132846832275391},{"id":"https://openalex.org/C79162176","wikidata":"https://www.wikidata.org/wiki/Q5520338","display_name":"Gamma globulin","level":3,"score":0.4860716164112091},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46649524569511414},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.454474538564682},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42197465896606445},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34718188643455505},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.2000943422317505},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.17106780409812927},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.17075064778327942},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.16104096174240112},{"id":"https://openalex.org/C2780349322","wikidata":"https://www.wikidata.org/wiki/Q11088","display_name":"Coeliac disease","level":3,"score":0.13635537028312683},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07160717248916626},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000361","descriptor_name":"Agammaglobulinemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009157","descriptor_name":"Myasthenia Gravis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D013945","descriptor_name":"Thymoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D013953","descriptor_name":"Thymus Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2996329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2996329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Case Reports"},{"id":"mag:2411202201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2996329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W41380831","https://openalex.org/W2105484919","https://openalex.org/W2117531097","https://openalex.org/W2978922711","https://openalex.org/W4417294357","https://openalex.org/W4237691874","https://openalex.org/W7169578169","https://openalex.org/W2907564020","https://openalex.org/W4313656989","https://openalex.org/W2018655347"],"abstract_inverted_index":{"An":[0],"elderly":[1],"man":[2],"with":[3,37,65],"thymoma,":[4],"myasthenia":[5],"gravis,":[6],"and":[7,39,52,59],"hypogammaglobulinemia":[8],"developed":[9],"profuse":[10],"watery":[11],"diarrhea.":[12],"Infusions":[13],"of":[14,48,72],"gamma-globulin":[15],"caused":[16],"the":[17,49],"diarrhea":[18],"to":[19,24,32,69],"resolve.":[20],"The":[21],"patient":[22],"succumbed":[23],"fulminant":[25],"bronchopneumonia.":[26,53],"At":[27],"necropsy":[28],"he":[29],"was":[30],"found":[31],"have":[33],"widespread":[34],"cytomegalovirus":[35],"infection":[36,58],"duodenal":[38],"ileal":[40],"ulceration,":[41],"subtotal":[42],"villous":[43],"atrophy,":[44],"marked":[45],"nonspecific":[46],"inflammation":[47],"small":[50],"intestine":[51],"In":[54],"addition":[55],"Herpes":[56],"simplex":[57],"invasive":[60],"candidiasis":[61],"were":[62],"present.":[63],"Patients":[64],"immunodeficiency":[66],"are":[67],"susceptible":[68],"a":[70],"variety":[71],"gastrointestinal":[73],"pathogens,":[74],"particularly":[75],"viral.":[76]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}