{"id":"https://openalex.org/W2411186166","doi":"https://doi.org/10.1007/bf03657365","title":"Regulation of cerebrovascular endothelial peroxisome proliferator activator receptor alpha expression and nitric oxide production by clofibrate","display_name":"Regulation of cerebrovascular endothelial peroxisome proliferator activator receptor alpha expression and nitric oxide production by clofibrate","publication_year":2010,"publication_date":"2010-05-01","ids":{"openalex":"https://openalex.org/W2411186166","doi":"https://doi.org/10.1007/bf03657365","mag":"2411186166","pmid":"https://pubmed.ncbi.nlm.nih.gov/20568414"},"language":"en","primary_location":{"id":"doi:10.1007/bf03657365","doi":"https://doi.org/10.1007/bf03657365","is_oa":true,"landing_page_url":"https://doi.org/10.1007/bf03657365","pdf_url":"https://link.springer.com/content/pdf/10.1007/BF03657365.pdf","source":{"id":"https://openalex.org/S2756093218","display_name":"Bratislavske\u0301 leka\u0301rske listy/Bratislava medical journal","issn_l":"0006-9248","issn":["0006-9248","1336-0345"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bratislava Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/BF03657365.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074800822","display_name":"Momoh Audu Yakubu","orcid":"https://orcid.org/0000-0002-6072-2473","observed_orcids":["https://orcid.org/0000-0002-6072-2473"]},"institutions":[{"id":"https://openalex.org/I48205209","display_name":"Texas Southern University","ror":"https://ror.org/05ch0aw77","country_code":"US","type":"education","lineage":["https://openalex.org/I48205209"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Momoh A Yakubu","raw_affiliation_strings":["College of Pharmacy and Health Sciences , Texas Southern University , Suite 104 Gray Hall , 3100 Cleburne Avenue , Houston , TX 77004 ","Vascular Biology Unit , Center for Cardiovascular Diseases , College of Pharmacy and Health Sciences , Texas Southern University , Houston","Vascular Biology Unit, Center for Cardiovascular Diseases, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Health Sciences , Texas Southern University , Suite 104 Gray Hall , 3100 Cleburne Avenue , Houston , TX 77004 ","institution_ids":["https://openalex.org/I48205209"]},{"raw_affiliation_string":"Vascular Biology Unit , Center for Cardiovascular Diseases , College of Pharmacy and Health Sciences , Texas Southern University , Houston","institution_ids":["https://openalex.org/I48205209"]},{"raw_affiliation_string":"Vascular Biology Unit, Center for Cardiovascular Diseases, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA","institution_ids":["https://openalex.org/I48205209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056826016","display_name":"Rami H Nsaif","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rami H Nsaif","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056132267","display_name":"Adebayo Oyekan","orcid":"https://orcid.org/0000-0002-8966-3921","observed_orcids":["https://orcid.org/0000-0002-8966-3921"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adebayo O Oyekan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":0.3905,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.60763768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"111","issue":"5","first_page":"258","last_page":"264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clofibrate","display_name":"clofibrate","score":0.9409999847412109},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.9629999995231628},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/protein-kinase-c-signaling","display_name":"protein kinase C signaling","score":0.9039999842643738},{"id":"https://openalex.org/keywords/calphostin-c","display_name":"calphostin C","score":0.9110000133514404},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9789999723434448},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.7289999723434448},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.753000020980835},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2779496979","wikidata":"https://www.wikidata.org/wiki/Q2701912","display_name":"Clofibrate","level":2,"score":0.8881571292877197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7004011273384094},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6889523863792419},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.6299251317977905},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5762306451797485},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4665180444717407},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4599446654319763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3331679403781891},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12649887800216675}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D002994","descriptor_name":"Clofibrate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/bf03657365","doi":"https://doi.org/10.1007/bf03657365","is_oa":true,"landing_page_url":"https://doi.org/10.1007/bf03657365","pdf_url":"https://link.springer.com/content/pdf/10.1007/BF03657365.pdf","source":{"id":"https://openalex.org/S2756093218","display_name":"Bratislavske\u0301 leka\u0301rske listy/Bratislava medical journal","issn_l":"0006-9248","issn":["0006-9248","1336-0345"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bratislava Medical Journal","raw_type":"journal-article"},{"id":"pmid:20568414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20568414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bratislavske lekarske listy","raw_type":"Journal Article"},{"id":"mag:2411186166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20568414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1007/bf03657365","doi":"https://doi.org/10.1007/bf03657365","is_oa":true,"landing_page_url":"https://doi.org/10.1007/bf03657365","pdf_url":"https://link.springer.com/content/pdf/10.1007/BF03657365.pdf","source":{"id":"https://openalex.org/S2756093218","display_name":"Bratislavske\u0301 leka\u0301rske listy/Bratislava medical journal","issn_l":"0006-9248","issn":["0006-9248","1336-0345"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bratislava Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G398401327","display_name":null,"funder_award_id":"HL03674","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5435409521","display_name":null,"funder_award_id":"HL-70669","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5939445781","display_name":"Cerebral Microvascular Endothelin Production","funder_award_id":"R15HL070669","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8438083053","display_name":"TEXAS SOUTHERN UNIVERSITY RESEARCH SCIENTIST AWARD","funder_award_id":"R25HL003674","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320334601","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2411186166.pdf","grobid_xml":"https://content.openalex.org/works/W2411186166.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W66239920","https://openalex.org/W1919291000","https://openalex.org/W1984171775","https://openalex.org/W1985709687","https://openalex.org/W1988795259","https://openalex.org/W1993008296","https://openalex.org/W2015437912","https://openalex.org/W2020248217","https://openalex.org/W2042006175","https://openalex.org/W2047401628","https://openalex.org/W2051904771","https://openalex.org/W2075385622","https://openalex.org/W2082502030","https://openalex.org/W2085973940","https://openalex.org/W2086524338","https://openalex.org/W2098132645","https://openalex.org/W2098881393","https://openalex.org/W2100079215","https://openalex.org/W2107869341","https://openalex.org/W2109932727","https://openalex.org/W2110733021","https://openalex.org/W2114334408","https://openalex.org/W2119617266","https://openalex.org/W2135801405","https://openalex.org/W2148403865","https://openalex.org/W2162822326","https://openalex.org/W2169878907","https://openalex.org/W2231232140","https://openalex.org/W2464065178","https://openalex.org/W2464068899"],"related_works":["https://openalex.org/W166394769","https://openalex.org/W2109932727","https://openalex.org/W2110733021","https://openalex.org/W2004274360","https://openalex.org/W2982863016","https://openalex.org/W2379655460","https://openalex.org/W3144228112","https://openalex.org/W2052587548","https://openalex.org/W2006948677","https://openalex.org/W2054727930"],"abstract_inverted_index":{"BACKGROUND:":[0],"Peroxisome":[1],"proliferator":[2],"activator":[3,105],"receptor":[4,13],"alpha":[5,29,52,61,91,181,193,252,266],"(PPAR":[6],"alpha),":[7],"a":[8,50,263,269],"member":[9],"of":[10,47,57,85,103,116,132,145,164,222,257,283],"the":[11,24,45,55,83,99,197,246],"nuclear":[12],"superfamily,":[14],"is":[15],"known":[16],"to":[17],"increase":[18,155,174,210],"nitric":[19],"oxide":[20],"(NO)":[21],"production":[22,65,95,124],"and":[23,38,54,63,82,93,136,171,216,259,278],"mechanisms":[25],"by":[26,125,231],"which":[27],"PPAR":[28,51,60,90,180,192,214,223,251,265,284],"activation":[30,37,253,277,282],"alleviates":[31],"vascular":[32],"dysfunction":[33],"may":[34],"predicate":[35],"its":[36],"possible":[39],"expression.":[40,224],"OBJECTIVES:":[41],"We":[42],"have":[43],"evaluated":[44],"effects":[46],"acute":[48,88],"clofibrate,":[49],"ligand":[53],"role":[56,84],"PKC":[58,86,104,260,271,276],"on":[59,141],"expression":[62,92,182,194,226,267,285],"NO":[64,94,123,142,157,165,176,255],"in":[66,87,98,156,175,213,238,245],"cultured":[67,81],"cerebral":[68],"microvascular":[69,248],"endothelial":[70,249],"cell":[71],"(CMVEC).":[72],"METHODS:":[73],"Confluent":[74],"CMVEC":[75,117],"derived":[76],"from":[77],"pig":[78],"brain":[79,247],"were":[80],"clofibrate-induced":[89,154,173,209,281],"was":[96,227],"determined":[97],"presence":[100],"or":[101,110,120,127,188,234,237],"absence":[102],"phorbol":[106],"myristate":[107],"acetate":[108],"(PMA)":[109],"inhibitor":[111,163],"(calphostin":[112],"C).":[113],"RESULTS:":[114],"Incubation":[115,144],"with":[118,134,147,187],"clofibrate":[119,137,190,233],"PMA":[121,135,151,186],"increased":[122,179],"40%":[126],"27%,":[128],"respectively,":[129],"whereas":[130],"co-incubation":[131],"cells":[133,146],"had":[138],"no":[139],"effect":[140],"production.":[143,158,177],"Calphostin":[148],"C":[149,201],"blunted":[150],"but":[152],"not":[153,228],"L-NAME":[159],"(0.1":[160],"mM),":[161],"an":[162],"synthase,":[166],"reduced":[167,191,202,218,280],"basal":[168,203],"(47%;":[169],"p<0.01)":[170,212],"abolished":[172],"Clofibrate":[178],"(26%;":[183],"p<0.05)":[184],"while":[185],"without":[189],"(p<0.01).":[195],"On":[196],"other":[198],"hand,":[199],"calphostin":[200],"(69%,":[204],"ap<0.01)":[205],"as":[206,208,274],"well":[207],"(59%,":[211],"expression,":[215],"further":[217],"PMA-induced":[219],"down":[220],"regulation":[221],"eNOS":[225,258],"significantly":[229],"affected":[230],"either":[232],"PMA,":[235],"alone":[236],"combination.":[239],"CONCLUSION:":[240],"These":[241],"results":[242],"show":[243],"that":[244],"cell,":[250],"increases":[254],"production-independent":[256],"signaling":[261,272],"pathways,":[262],"regulates":[264],"through":[268],"complex":[270],"mechanism(s)":[273],"both":[275],"inhibition":[279],"(Fig.":[286],"4,":[287],"Ref.":[288],"32).":[289],"Full":[290],"Text":[291],"(Free,":[292],"PDF)":[293],"www.bmj.sk.":[294]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
