{"id":"https://openalex.org/W2411148786","doi":null,"title":"Regulation of glycolytic flux in the heart of the fetal guinea pig.","display_name":"Regulation of glycolytic flux in the heart of the fetal guinea pig.","publication_year":1983,"publication_date":"1983-02-01","ids":{"openalex":"https://openalex.org/W2411148786","mag":"2411148786","pmid":"https://pubmed.ncbi.nlm.nih.gov/6300215"},"language":"en","primary_location":{"id":"pmid:6300215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6300215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of developmental physiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068314774","display_name":"Tim Rolph","orcid":"https://orcid.org/0000-0001-5284-6903","observed_orcids":["https://orcid.org/0000-0001-5284-6903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T P Rolph","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060987083","display_name":"C T Jones","orcid":"https://orcid.org/0000-0001-8054-2077","observed_orcids":["https://orcid.org/0000-0001-8054-2077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C T Jones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.32472399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"5","issue":"1","first_page":"31","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycolytic-flux","display_name":"glycolytic flux","score":0.8410000205039978},{"id":"https://openalex.org/keywords/fetal-heart","display_name":"fetal heart","score":0.925000011920929},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.7229999899864197},{"id":"https://openalex.org/keywords/oxygen-deprivation","display_name":"oxygen deprivation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/phosphofructokinase","display_name":"phosphofructokinase","score":0.8550000190734863},{"id":"https://openalex.org/keywords/anaerobic-glycolysis","display_name":"anaerobic glycolysis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/lactic-acid-production","display_name":"lactic acid production","score":0.7919999957084656},{"id":"https://openalex.org/keywords/glycogen","display_name":"glycogen","score":0.4869999885559082},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7020000219345093},{"id":"https://openalex.org/keywords/myocardial-energy-metabolism","display_name":"myocardial energy metabolism","score":0.574999988079071},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.8400880098342896},{"id":"https://openalex.org/C122245378","wikidata":"https://www.wikidata.org/wiki/Q14771739","display_name":"Phosphofructokinase","level":4,"score":0.8243455290794373},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6257561445236206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6156627535820007},{"id":"https://openalex.org/C55885012","wikidata":"https://www.wikidata.org/wiki/Q4750801","display_name":"Anaerobic glycolysis","level":4,"score":0.6111786961555481},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5911588668823242},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5343747735023499},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5275055170059204},{"id":"https://openalex.org/C2779372652","wikidata":"https://www.wikidata.org/wiki/Q427147","display_name":"Phosphofructokinase 1","level":5,"score":0.5251145958900452},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.5069025158882141},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.5061082243919373},{"id":"https://openalex.org/C5140985","wikidata":"https://www.wikidata.org/wiki/Q483866","display_name":"Anaerobic exercise","level":2,"score":0.4128669500350952},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3494061231613159},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2362232506275177},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20325589179992676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11119642853736877},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.08815327286720276},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.08233559131622314},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000693","descriptor_name":"Anaerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005318","descriptor_name":"Fetal Heart","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005318","descriptor_name":"Fetal Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005318","descriptor_name":"Fetal Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6300215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6300215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of developmental physiology","raw_type":"Journal Article"},{"id":"mag:2411148786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6300215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009248023","https://openalex.org/W2405709479","https://openalex.org/W2039052218","https://openalex.org/W2040463374","https://openalex.org/W2395270642","https://openalex.org/W2124716588","https://openalex.org/W2077920541","https://openalex.org/W1982446540","https://openalex.org/W1967531331","https://openalex.org/W2408681826"],"abstract_inverted_index":{"Functional":[0],"glycolytic":[1,26,137,155],"capacity":[2,75],"and":[3,19,40,44,58,125,151,172],"its":[4,175],"regulation":[5],"have":[6],"been":[7],"studied":[8],"in":[9,17,20,37,56,59,111,123,166],"the":[10,21,38,60,65,112,118,128,147,157,167],"fetal":[11,43,50,81,113,168],"guinea-pig":[12,46],"heart":[13,62,82,114],"during":[14,80,91],"O2":[15,54,92,149,179],"deprivation":[16,55,93],"situ":[18,57],"Langendorff":[22],"perfused":[23,61],"heart.":[24],"Anaerobic":[25],"flux,":[27,156],"at":[28,85,98,127],"2":[29],"mumol/min":[30],"per":[31],"g":[32],"wet":[33],"wt.":[34],"was":[35,64,89,104,115,162],"similar":[36],"48-50":[39,86],"60-65":[41,99],"days":[42,87,100],"adult":[45,170],"heart,":[47,171],"despite":[48],"lower":[49],"phosphofructokinase":[51,103],"activity.":[52],"During":[53],"glucose":[63],"major":[66],"substrate,":[67],"with":[68,143],"glycogen":[69],"making":[70],"a":[71],"smaller":[72],"contribution.":[73],"Glycolytic":[74],"became":[76],"more":[77],"tightly":[78],"regulated":[79],"development.":[83],"Thus":[84],"glycolysis":[88],"increased":[90],"by":[94,117],"substrate":[95],"supply,":[96],"but":[97],"activation":[101],"of":[102,120,130,135,146,159],"required":[105],"also.":[106],"Low":[107],"malate/aspartate":[108],"cycle":[109],"activity":[110],"suggested":[116],"absence":[119],"an":[121],"increase":[122],"malate":[124],"alanine":[126],"expense":[129],"aspartate.":[131],"The":[132],"large":[133],"proportion":[134,158],"aerobic":[136,154],"flux":[138],"converted":[139],"to":[140,178],"lactate":[141],"concurred":[142],"this.":[144],"Because":[145],"low":[148],"consumption":[150],"relatively":[152],"high":[153],"glycolytically-derived":[160],"ATP":[161],"3-4":[163],"fold":[164],"higher":[165],"than":[169],"may":[173],"explain":[174],"functional":[176],"resistance":[177],"deprivation.":[180]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}