{"id":"https://openalex.org/W2411043687","doi":null,"title":"Development of an implantable drug delivery catheter.","display_name":"Development of an implantable drug delivery catheter.","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W2411043687","mag":"2411043687","pmid":"https://pubmed.ncbi.nlm.nih.gov/1751157"},"language":"en","primary_location":{"id":"pmid:1751157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1751157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASAIO transactions","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112524155","display_name":"Jan J. Lewandowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Lewandowski","raw_affiliation_strings":["Applied Medical Research Inc., Independence, Ohio 44131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Medical Research Inc., Independence, Ohio 44131","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089124040","display_name":"George J. Picha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G J Picha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013971903","display_name":"Anson Nguyen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J Nguyen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090223198","display_name":"D. Bressen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Bressen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33895921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"3","first_page":"M295","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/implantable-drug-delivery-systems","display_name":"implantable drug delivery","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mass-transport-rate","display_name":"mass transport rate","score":0.9430000185966492},{"id":"https://openalex.org/keywords/subcutaneous-drug-delivery","display_name":"subcutaneous drug delivery","score":0.609000027179718},{"id":"https://openalex.org/keywords/fibrous-capsule-formation","display_name":"fibrous capsule formation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/occlusion","display_name":"occlusion","score":0.5180000066757202},{"id":"https://openalex.org/keywords/implant-survival","display_name":"implant survival","score":0.4259999990463257},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6446184515953064},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5798314809799194},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.5434272289276123},{"id":"https://openalex.org/C2778778583","wikidata":"https://www.wikidata.org/wiki/Q147768","display_name":"Capsule","level":2,"score":0.5316116809844971},{"id":"https://openalex.org/C2989209122","wikidata":"https://www.wikidata.org/wiki/Q178512","display_name":"Mass transport","level":2,"score":0.530600905418396},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.49714258313179016},{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.43963623046875},{"id":"https://openalex.org/C105289051","wikidata":"https://www.wikidata.org/wiki/Q1930094","display_name":"Pillar","level":2,"score":0.4374259114265442},{"id":"https://openalex.org/C2776561332","wikidata":"https://www.wikidata.org/wiki/Q5554853","display_name":"Depot","level":2,"score":0.4272107183933258},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40735873579978943},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38156113028526306},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3116019368171692},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28125542402267456},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21734189987182617},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.15871131420135498},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10019668936729431},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0797421932220459},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.07664799690246582},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.06825736165046692},{"id":"https://openalex.org/C61696701","wikidata":"https://www.wikidata.org/wiki/Q770766","display_name":"Engineering physics","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002408","descriptor_name":"Catheters, Indwelling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007208","descriptor_name":"Indocyanine Green","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015918","descriptor_name":"Infusion Pumps, Implantable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1751157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1751157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASAIO transactions","raw_type":"Journal Article"},{"id":"mag:2411043687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1751157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2320269004","https://openalex.org/W2412439090","https://openalex.org/W2028892040","https://openalex.org/W2066938739","https://openalex.org/W7039458510","https://openalex.org/W2416208254","https://openalex.org/W2913207355","https://openalex.org/W2401271433","https://openalex.org/W1573632739","https://openalex.org/W2539616560"],"abstract_inverted_index":{"A":[0],"microtextured,":[1],"pillared":[2,129],"drug":[3,76],"delivery":[4,77],"system":[5,78],"has":[6,15,131],"been":[7],"designed":[8],"and":[9,57,88,110,137],"tested":[10],"in":[11,45,142,149,155,159],"rabbits.":[12],"This":[13],"model":[14],"allowed":[16],"for":[17,100],"the":[18,21,48,94,118,128,151],"calculation":[19],"of":[20,68,146,165],"mass":[22,35,147,166],"transport":[23,36,167],"rate":[24,37,145],"indicating":[25],"after":[26,123],"a":[27,32,66,74,124],"4":[28],"week":[29],"time":[30],"period":[31],"pillar":[33],"device's":[34],"K1":[38],"[min-1]":[39],"is":[40,52,61,72,79,89,103,139],"K1p":[41],"1.54":[42],"x":[43,55,63],"10(-2)":[44,56],"contrast":[46,150],"to":[47,105,112],"smooth":[49,95,152],"control":[50,96,153],"which":[51,60],"K1C":[53],".043":[54],"K1im":[58],"IM":[59],"0.136":[62],"10(-2).":[64],"As":[65],"result":[67],"these":[69],"experiments,":[70],"it":[71],"apparent":[73],"micropillared":[75,119],"an":[80,85],"order":[81],"magnitude":[82,143],"faster":[83,92],"than":[84,93],"intramuscular":[86],"injection":[87],"30":[90],"times":[91],"device.":[97],"The":[98],"etiology":[99],"this":[101],"difference":[102],"related":[104],"close":[106],"blood":[107],"vessel":[108],"proximity":[109],"minimal":[111],"no":[113,140],"fibrous":[114],"capsule":[115],"formation":[116],"with":[117,162],"implant.":[120],"Finally,":[121],"even":[122],"6-month":[125],"implantation":[126],"time,":[127],"device":[130],"greater":[132],"reproducibility":[133],"regarding":[134],"curve":[135],"profile":[136],"there":[138],"loss":[141,164],"or":[144],"transport,":[148],"devices":[154],"many":[156],"instances":[157],"resulted":[158],"complete":[160],"occlusion":[161],"total":[163],"capabilities.":[168]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}