{"id":"https://openalex.org/W2410997635","doi":null,"title":"A controlled clinical trial of calcium dobesylate in the treatment of diabetic retinopathy.","display_name":"A controlled clinical trial of calcium dobesylate in the treatment of diabetic retinopathy.","publication_year":1977,"publication_date":"1977-03-01","ids":{"openalex":"https://openalex.org/W2410997635","mag":"2410997635","pmid":"https://pubmed.ncbi.nlm.nih.gov/323086"},"language":"en","primary_location":{"id":"pmid:323086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/323086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabete & metabolisme","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110257215","display_name":"Jean\u2010Claude Daubresse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Daubresse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021003334","display_name":"Rashna Meunier","orcid":"https://orcid.org/0000-0003-4478-0988","observed_orcids":["https://orcid.org/0000-0003-4478-0988"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Meunier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019214812","display_name":"P Dumont","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Dumont","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8718,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.77997218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"3","issue":"1","first_page":"27","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12599","display_name":"Retinal and Optic Conditions","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/proliferative-diabetic-retinopathy","display_name":"proliferative diabetic retinopathy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/microaneurysms","display_name":"microaneurysms","score":0.9559999704360962},{"id":"https://openalex.org/keywords/microhemorrhages","display_name":"microhemorrhages","score":0.8970000147819519},{"id":"https://openalex.org/keywords/retinal-angiography","display_name":"retinal angiography","score":0.9300000071525574},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8060680031776428},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.7524012923240662},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6708517074584961},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.5560528039932251},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4911513030529022},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.4545851945877075},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.43699437379837036},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.41254401206970215},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3845272660255432},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38178640604019165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34677350521087646},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.13010525703430176},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10074788331985474},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001557","descriptor_name":"Benzenesulfonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002123","descriptor_name":"Calcium Dobesilate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002200","descriptor_name":"Capillary Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012166","descriptor_name":"Retinal Hemorrhage","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:323086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/323086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabete & metabolisme","raw_type":"Clinical Trial"},{"id":"mag:2410997635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/323086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2317067028","https://openalex.org/W1979804064","https://openalex.org/W2357429271","https://openalex.org/W2347960107","https://openalex.org/W2040197732","https://openalex.org/W2311703660","https://openalex.org/W2035640141","https://openalex.org/W2474141198","https://openalex.org/W1997562982","https://openalex.org/W2391291852"],"abstract_inverted_index":{"In":[0],"a":[1,32,58,68],"two-year":[2],"study":[3,90],"of":[4,45,88,101,116,130,153],"36":[5],"diabetic":[6],"patients":[7,23,84,97],"with":[8],"retinopathy,":[9],"proliferative":[10],"in":[11,20,82,95,111],"18,":[12],"first":[13],"six":[14,52,60],"months":[15,53],"(period":[16,34,71],"A)":[17],"were":[18,37,125,137],"spent":[19],"baseline.":[21],"The":[22],"then":[24,38],"received":[25],"calcium":[26],"dobesylate,":[27],"250":[28],"mg":[29],"three":[30],"times":[31],"day":[33],"B)":[35],"and":[36,73,123],"entered":[39],"into":[40],"the":[41,46,64,86,89,99,112,117,128,154],"double":[42,113],"blind":[43,114],"part":[44,115],"study,":[47],"receiving":[48],"either":[49],"dobesylate":[50],"for":[51,57],"followed":[54],"by":[55,98],"placebo":[56],"further":[59],"month":[61],"period,":[62],"or":[63],"reverse,":[65],"according":[66],"to":[67,148],"randomised":[69],"code":[70],"C":[72],"D).":[74],"Cutaneous":[75],"capillary":[76],"resistance":[77],"(CCR)":[78],"which":[79],"was":[80,108],"abnormal":[81],"26":[83],"at":[85,127,139],"beginning":[87],"had":[91],"returned":[92],"toward":[93],"normal":[94],"11":[96],"end":[100,129],"period":[102,141],"B.":[103],"However,":[104],"this":[105],"beneficial":[106,151],"effect":[107,152],"not":[109],"confirmed":[110],"study.":[118],"Punctate":[119],"red":[120],"spots":[121],"(microaneurysms":[122],"microhemorrhages)":[124],"counted":[126],"each":[131],"period.":[132],"No":[133],"statistically":[134],"significant":[135],"differences":[136],"noted":[138],"any":[140,150],"studied.":[142],"Retinal":[143],"angiographic":[144],"studies":[145],"also":[146],"failed":[147],"demonstrate":[149],"drug.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}