{"id":"https://openalex.org/W2410643270","doi":null,"title":"Anti-TNF\u03b1-therapy as an evidence-based treatment option for different clinical manifestations of psoriatic arthritis.","display_name":"Anti-TNF\u03b1-therapy as an evidence-based treatment option for different clinical manifestations of psoriatic arthritis.","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2410643270","mag":"2410643270","pmid":"https://pubmed.ncbi.nlm.nih.gov/26472504"},"language":"en","primary_location":{"id":"pmid:26472504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26472504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://publica.fraunhofer.de/documents/N-418462.html","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029412055","display_name":"Michaela K\u00f6hm","orcid":"https://orcid.org/0000-0002-3579-5574","observed_orcids":["https://orcid.org/0000-0002-3579-5574"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michaela K\u00f6hm","raw_affiliation_strings":["Rheumatology Department, Goethe-University Frankfurt am Main; and Fraunhofer IME, Projectgroup Translational Medicine and Pharmacology TMP at Goethe-University Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Department, Goethe-University Frankfurt am Main; and Fraunhofer IME, Projectgroup Translational Medicine and Pharmacology TMP at Goethe-University Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032343417","display_name":"Harald Burkhardt","orcid":"https://orcid.org/0000-0002-6261-3131","observed_orcids":["https://orcid.org/0000-0002-6261-3131"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Harald Burkhardt","raw_affiliation_strings":["Rheumatology Department, Goethe-University Frankfurt am Main; and Fraunhofer IME, Projectgroup Translational Medicine and Pharmacology TMP at Goethe-University Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Department, Goethe-University Frankfurt am Main; and Fraunhofer IME, Projectgroup Translational Medicine and Pharmacology TMP at Goethe-University Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012842018","display_name":"Frank Behrens","orcid":"https://orcid.org/0000-0001-8750-7186","observed_orcids":["https://orcid.org/0000-0001-8750-7186"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210134473","display_name":"Fraunhofer Institute for Molecular Biology and Applied Ecology","ror":"https://ror.org/03j85fc72","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210134473","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Behrens","raw_affiliation_strings":["Rheumatology Department, Goethe-University Frankfurt am Main; and Fraunhofer IME, Projectgroup Translational Medicine and Pharmacology TMP at Goethe-University Frankfurt am Main, Germany. frank.behrens@ime.fraunhofer.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Department, Goethe-University Frankfurt am Main; and Fraunhofer IME, Projectgroup Translational Medicine and Pharmacology TMP at Goethe-University Frankfurt am Main, Germany. frank.behrens@ime.fraunhofer.de","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210134473"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6922,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68846879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"33","issue":"5 Suppl 93","first_page":"S109","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriatic-arthritis","display_name":"psoriatic arthritis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anti-tnf-therapy","display_name":"anti-TNF therapy","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.9459999799728394},{"id":"https://openalex.org/keywords/peripheral-arthritis","display_name":"peripheral arthritis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/enthesitis","display_name":"enthesitis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dactylitis","display_name":"dactylitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/radiographic-progression","display_name":"radiographic progression","score":0.9850000143051147},{"id":"https://openalex.org/keywords/disease-manifestations","display_name":"disease manifestations","score":0.503000020980835},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.977386474609375},{"id":"https://openalex.org/C2778019847","wikidata":"https://www.wikidata.org/wiki/Q517782","display_name":"Dactylitis","level":5,"score":0.9159775376319885},{"id":"https://openalex.org/C2776260265","wikidata":"https://www.wikidata.org/wiki/Q511097","display_name":"Psoriatic arthritis","level":3,"score":0.8581581115722656},{"id":"https://openalex.org/C2780131103","wikidata":"https://www.wikidata.org/wiki/Q3055079","display_name":"Enthesitis","level":4,"score":0.7829837799072266},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.7039932012557983},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6220988631248474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4809809923171997},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4806629419326782},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4733331799507141},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4613476097583771},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4544728696346283},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38083159923553467},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18853473663330078},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.07366615533828735}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:26472504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26472504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"pmh:oai:fraunhofer.de:N-418462","doi":null,"is_oa":true,"landing_page_url":"http://publica.fraunhofer.de/documents/N-418462.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400801","display_name":"Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fraunhofer IME","raw_type":"Journal Article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/245665","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/245665","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"mag:2410643270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26472504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:fraunhofer.de:N-418462","doi":null,"is_oa":true,"landing_page_url":"http://publica.fraunhofer.de/documents/N-418462.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400801","display_name":"Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fraunhofer IME","raw_type":"Journal Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W79463722","https://openalex.org/W152686937","https://openalex.org/W1234335402","https://openalex.org/W1922566561","https://openalex.org/W1976172421","https://openalex.org/W1976217778","https://openalex.org/W1977445011","https://openalex.org/W1985680749","https://openalex.org/W1997999969","https://openalex.org/W2000183493","https://openalex.org/W2000500639","https://openalex.org/W2008716526","https://openalex.org/W2013361256","https://openalex.org/W2017720269","https://openalex.org/W2020050449","https://openalex.org/W2029629958","https://openalex.org/W2031172875","https://openalex.org/W2031504111","https://openalex.org/W2035642138","https://openalex.org/W2039186692","https://openalex.org/W2045317929","https://openalex.org/W2052398986","https://openalex.org/W2053889157","https://openalex.org/W2062890136","https://openalex.org/W2077358378","https://openalex.org/W2083136482","https://openalex.org/W2088228080","https://openalex.org/W2091422666","https://openalex.org/W2091442391","https://openalex.org/W2094124191","https://openalex.org/W2098927200","https://openalex.org/W2128141316","https://openalex.org/W2131999276","https://openalex.org/W2133696182","https://openalex.org/W2142180500","https://openalex.org/W2144794315","https://openalex.org/W2145778588","https://openalex.org/W2146966993","https://openalex.org/W2149118348","https://openalex.org/W2149168537","https://openalex.org/W2152245204","https://openalex.org/W2154515402","https://openalex.org/W2168698481","https://openalex.org/W2169930621","https://openalex.org/W2313246527","https://openalex.org/W2323608499","https://openalex.org/W2336449142","https://openalex.org/W2397530324","https://openalex.org/W2413177977"],"related_works":["https://openalex.org/W2098854264","https://openalex.org/W2982115245","https://openalex.org/W1926906892","https://openalex.org/W2200472334","https://openalex.org/W7096984739","https://openalex.org/W1557541442","https://openalex.org/W2009392302","https://openalex.org/W7020840807","https://openalex.org/W2060773419","https://openalex.org/W2136920783"],"abstract_inverted_index":{"The":[0,70],"development":[1],"programmes":[2],"of":[3,20,52,98,130,136,143,164],"different":[4,50],"TNF-blocking":[5],"agents":[6],"in":[7,66,110,132,161,171],"psoriatic":[8],"arthritis":[9,61,80],"(PsA)":[10],"not":[11,116],"only":[12],"provided":[13],"substantial":[14],"evidence":[15,45,72],"for":[16,46,75,93,102,106],"the":[17,21,31,40,103,120,133,137,141,144],"therapeutic":[18],"benefits":[19],"specific":[22,43],"treatment":[23,33,108,149],"options,":[24],"but":[25],"also":[26,150],"enabled":[27],"new":[28],"insights":[29],"into":[30],"differential":[32],"effects":[34,48],"on":[35,49,78,147,154],"distinct":[36,56],"disease":[37],"manifestations.":[38],"For":[39],"first":[41,104],"time,":[42],"robust":[44],"distinctive":[47],"manifestations":[51],"PsA,":[53],"as":[54,113],"a":[55,67,107],"entity":[57],"separate":[58],"from":[59,86,166],"rheumatoid":[60],"(RA),":[62],"has":[63],"been":[64],"generated":[65],"standardized":[68],"way.":[69],"clearest":[71],"was":[73,124],"shown":[74],"an":[76,96],"effect":[77],"peripheral":[79,121],"(polyarticular)":[81],"with":[82],"ACR20":[83],"response":[84],"rates":[85],"45":[87],"up":[88],"to":[89,119,126],"58%":[90],"(vs.":[91],"9-24%":[92],"placebo),":[94],"and":[95,157],"inhibition":[97],"radiographic":[99],"progression":[100],"demonstrated":[101,152],"time":[105],"principle":[109],"PsA.":[111],"However,":[112],"PsA":[114],"does":[115],"remain":[117],"confined":[118],"joints,":[122],"it":[123],"necessary":[125],"address":[127],"diverse":[128],"patterns":[129],"PsA-subtypes":[131],"outcome":[134],"measurements":[135],"anti-TNF":[138,148],"trials.":[139],"Accordingly,":[140],"results":[142,165],"clinical":[145],"studies":[146],"have":[151],"efficacy":[153],"enthesitis,":[155],"dactylitis":[156],"skin":[158],"psoriasis,":[159],"either":[160],"sub":[162],"analysis":[163],"phase":[167],"III":[168],"RCTs,":[169],"or":[170],"additional":[172],"prospective":[173],"studies.":[174]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}