{"id":"https://openalex.org/W2410503152","doi":null,"title":"Suppression of acute inflammation by 15 methyl prostaglandin E1.","display_name":"Suppression of acute inflammation by 15 methyl prostaglandin E1.","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W2410503152","mag":"2410503152","pmid":"https://pubmed.ncbi.nlm.nih.gov/2841538"},"language":"en","primary_location":{"id":"pmid:2841538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2841538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113550782","display_name":"Guillermo Tate","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G A Tate","raw_affiliation_strings":["Department of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017608818","display_name":"Brian F. Mandell","orcid":"https://orcid.org/0000-0002-4416-1194","observed_orcids":["https://orcid.org/0000-0002-4416-1194"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B F Mandell","raw_affiliation_strings":["#N#               * University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109387464","display_name":"H. Ralph Schumacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H R Schumacher","raw_affiliation_strings":["#N#               * University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064923635","display_name":"Robert B. Zurier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R B Zurier","raw_affiliation_strings":["#N#               * University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":1.8891,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.83581512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"59","issue":"2","first_page":"192","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e1","display_name":"prostaglandin E1","score":0.8669999837875366},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.8209999799728394},{"id":"https://openalex.org/keywords/acute-inflammation","display_name":"acute inflammation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/air-pouch-model","display_name":"air pouch model","score":0.746999979019165},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/monosodium-urate-crystals","display_name":"monosodium urate crystals","score":0.9330000281333923},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":1.0},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.9089999794960022},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.8190000057220459},{"id":"https://openalex.org/keywords/vascular-reactivity","display_name":"vascular reactivity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/exudate","display_name":"exudate","score":0.722000002861023},{"id":"https://openalex.org/keywords/beta-galactosidase","display_name":"beta-galactosidase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.8443464636802673},{"id":"https://openalex.org/C2776685179","wikidata":"https://www.wikidata.org/wiki/Q2704449","display_name":"Leukotriene B4","level":3,"score":0.7257344126701355},{"id":"https://openalex.org/C2780101441","wikidata":"https://www.wikidata.org/wiki/Q949930","display_name":"Pouch","level":2,"score":0.616897702217102},{"id":"https://openalex.org/C2779837120","wikidata":"https://www.wikidata.org/wiki/Q579348","display_name":"Prostaglandin E1","level":2,"score":0.5769163370132446},{"id":"https://openalex.org/C2778573061","wikidata":"https://www.wikidata.org/wiki/Q1139400","display_name":"Exudate","level":2,"score":0.5279138088226318},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.5232909321784973},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.4352937936782837},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4351711869239807},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42803773283958435},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.4242342412471771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.419705331325531},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38784247636795044},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3557528257369995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3290012776851654},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24356737732887268},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08360305428504944}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007975","descriptor_name":"Leukotriene B4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009240","descriptor_name":"N-Formylmethionine Leucyl-Phenylalanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2841538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2841538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:2410503152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2841538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2109362436","https://openalex.org/W2050326142","https://openalex.org/W1998727869","https://openalex.org/W2071264144","https://openalex.org/W1557197959","https://openalex.org/W7096156861","https://openalex.org/W585755835","https://openalex.org/W2077172352","https://openalex.org/W2128198913","https://openalex.org/W2113683216"],"abstract_inverted_index":{"Prostaglandins":[0],"are":[1],"important":[2],"regulators":[3],"of":[4,23,26,85,88,95,115,132,151,167,184,192,204,217,220,227,232,248],"inflammatory":[5,57,97,179],"responses.":[6],"The":[7,45,181],"rat":[8],"subcutaneous":[9],"air":[10],"pouch,":[11],"a":[12,50],"model":[13],"for":[14,80],"synovial":[15],"inflammation,":[16],"was":[17,49,124,142,187,211],"used":[18,143],"to":[19,144],"study":[20],"the":[21,96,116,129,161,202,242,254],"effect":[22,183],"systemic":[24,225],"injections":[25],"prostaglandin":[27,36],"E1":[28,37],"(PGE1)":[29],"and":[30,71,107,113,136,170,252],"its":[31],"stable":[32],"analog":[33,48],"15S,15":[34],"methyl":[35],"(15M":[38],"PGE1)":[39],"on":[40],"nonimmunologically":[41],"induced":[42,60,212,236],"acute":[43,178,234],"inflammation.":[44,86,146,218],"15M":[46,101,122,157,185,198,228],"PGE1":[47,79,102,123,158,186,199,229],"more":[51],"effective":[52,126],"longer-lasting":[53],"antiinflammatory":[54,182],"agent.":[55],"Acute":[56],"responses":[58],"were":[59,74],"with":[61,76,121,197],"three":[62,215],"diverse":[63],"stimuli":[64,216],"including":[65],"monosodium":[66,238],"urate":[67,239],"crystals,":[68,240],"leukotriene":[69,140,250],"B4":[70,141],"formylmethionylleucyl-phenylalanine.":[72],"Animals":[73],"treated":[75],"15":[77],"M":[78],"2":[81],"days":[82],"before":[83],"induction":[84],"Analysis":[87],"pouch":[89,152,193,205],"fluid":[90,130],"6":[91],"hours":[92],"after":[93],"injection":[94],"stimulus":[98],"indicates":[99],"that":[100,156,224],"treatment":[103],"suppressed":[104],"exudate":[105],"volume":[106,135],"protein":[108,137],"concentration,":[109],"polymorphonuclear":[110,208],"leucocyte":[111],"accumulation":[112],"activity":[114],"lysosomal":[117],"enzyme":[118],"beta-galactosidase.":[119],"Treatment":[120,196],"least":[125],"in":[127,176],"preventing":[128],"phase":[131],"inflammation":[133,235,249],"(exudate":[134],"concentration)":[138],"when":[139],"induce":[145],"Direct":[147],"observation":[148],"(dissecting":[149],"microscope)":[150],"lining":[153,194],"vessels":[154,169],"indicated":[155],"reduced":[159,200],"markedly":[160],"intense":[162],"vascular":[163],"reactivity":[164],"(increased":[165],"number":[166],"dilated":[168],"filamentous,":[171],"corkscrew-shaped":[172],"vessels)":[173],"usually":[174],"seen":[175],"an":[177],"response.":[180],"also":[188],"documented":[189],"by":[190,207,213,237,241,253],"histopathology":[191],"tissue.":[195],"substantially":[201],"invasion":[203],"tissue":[206],"leucocytes":[209],"which":[210],"all":[214],"Results":[219],"these":[221],"experiments":[222],"show":[223],"administration":[226],"is":[230],"capable":[231],"suppressing":[233],"potent":[243],"soluble":[244],"naturally":[245],"occurring":[246],"mediator":[247],"B4,":[251],"synthetic":[255],"chemotactic":[256],"peptide,":[257],"formylmethionylleucylphenylalanine.":[258]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}