{"id":"https://openalex.org/W2410354582","doi":null,"title":"On the brain endocoid for benzodiazepine recognition sites.","display_name":"On the brain endocoid for benzodiazepine recognition sites.","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W2410354582","mag":"2410354582","pmid":"https://pubmed.ncbi.nlm.nih.gov/3001768"},"language":"en","primary_location":{"id":"pmid:3001768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3001768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in clinical and biological research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048825104","display_name":"Alessandro Guidotti","orcid":"https://orcid.org/0000-0003-4480-0010","observed_orcids":["https://orcid.org/0000-0003-4480-0010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Guidotti","raw_affiliation_strings":["Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"P Ferrero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Ferrero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"E Costa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Costa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2907,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.4866121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"192","issue":null,"first_page":"477","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dbi","display_name":"DBI","score":0.6710000038146973},{"id":"https://openalex.org/keywords/benzodiazepine-binding-site","display_name":"benzodiazepine binding site","score":0.8880000114440918},{"id":"https://openalex.org/keywords/benzodiazepine-receptor","display_name":"benzodiazepine receptor","score":0.7820000052452087},{"id":"https://openalex.org/keywords/benzodiazepine-receptor-agonists","display_name":"benzodiazepine receptor agonists","score":0.7099999785423279},{"id":"https://openalex.org/keywords/conflict-test","display_name":"conflict test","score":0.49300000071525574},{"id":"https://openalex.org/keywords/punishment","display_name":"punishment","score":0.31299999356269836},{"id":"https://openalex.org/keywords/anxiety-regulation","display_name":"anxiety regulation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/lysine-and-arginine-residues","display_name":"lysine and arginine residues","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C205044023","wikidata":"https://www.wikidata.org/wiki/Q4778117","display_name":"Anxiogenic","level":4,"score":0.9157943725585938},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.7797057032585144},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.5792953372001648},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.578616738319397},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.54323410987854},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.5310291051864624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5121359825134277},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.451670378446579},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.4444637596607208},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4336371421813965},{"id":"https://openalex.org/C89951826","wikidata":"https://www.wikidata.org/wiki/Q1671731","display_name":"Inverse agonist","level":4,"score":0.4290936291217804},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.412163645029068},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2877017855644226},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2716081440448761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2687786817550659}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003488","descriptor_name":"Cyanogen Bromide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013570","descriptor_name":"Synaptic Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3001768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3001768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in clinical and biological research","raw_type":"Journal Article"},{"id":"mag:2410354582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3001768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2048791827","https://openalex.org/W2080359769","https://openalex.org/W2082070124","https://openalex.org/W2072197361","https://openalex.org/W2018562021","https://openalex.org/W1976440389","https://openalex.org/W2078206080","https://openalex.org/W2055990086","https://openalex.org/W2027579597","https://openalex.org/W2010400196"],"abstract_inverted_index":{"Human":[0],"and":[1,18,74,128],"rat":[2],"brain":[3,27],"contain":[4],"a":[5,40,87,90],"neuropeptide":[6],"with":[7],"105":[8],"amino":[9],"acid":[10],"residues":[11,76],"which":[12,36,93],"inhibits":[13],"the":[14,48,65,78,104,110,134],"binding":[15],"of":[16,72,89,109,113],"3H-diazepam":[17],"other":[19],"specific":[20],"benzodiazepine":[21,66,105,121],"recognition":[22,67,106],"site":[23],"ligands":[24],"to":[25,39],"crude":[26],"synaptic":[28],"membranes.":[29],"DBI":[30,58,79],"injected":[31],"intracerebroventricularly":[32],"in":[33,77],"thirsty":[34],"rats":[35],"are":[37],"subjected":[38],"conflict":[41],"test":[42,57],"(Corda":[43],"et":[44],"al.,":[45],"1983),":[46],"lowers":[47],"threshold":[49],"for":[50,64,103],"behavioral":[51],"suppression":[52],"by":[53],"punishment.":[54],"In":[55],"this":[56,83,114],"acts":[59,99],"like":[60],"an":[61,101,126,131],"anxiogenic":[62,111],"endocoid":[63,92,98],"sites.":[68],"The":[69],"large":[70],"abundance":[71],"lysine":[73],"arginine":[75],"molecule":[80],"suggest":[81],"that":[82,119],"polypeptide":[84],"functions":[85],"as":[86,100,125,130],"precursor":[88],"putative":[91],"regulates":[94],"anxiety":[95],"levels.":[96],"This":[97],"agonist":[102,132],"site.":[107],"Because":[108],"properties":[112],"endocoid,":[115],"it":[116],"is":[117],"proposed":[118],"anxiolytic":[120],"should":[122],"be":[123],"classified":[124],"antagonist":[127],"beta-carboline":[129],"at":[133],"receptor":[135],"level.":[136]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}