{"id":"https://openalex.org/W2410169484","doi":null,"title":"Sensitivity of anticancer drugs in Saos-2 cells transfected with mutant p53 varied with mutation point.","display_name":"Sensitivity of anticancer drugs in Saos-2 cells transfected with mutant p53 varied with mutation point.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2410169484","mag":"2410169484","pmid":"https://pubmed.ncbi.nlm.nih.gov/9568097"},"language":"en","primary_location":{"id":"pmid:9568097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9568097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074869340","display_name":"L H Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"L H Wang","raw_affiliation_strings":["Department of Radiation Biophysics, Nagasaki University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Biophysics, Nagasaki University School of Medicine, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046288264","display_name":"Kumio Okaichi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Okaichi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047305720","display_name":"Manabu Ihara","orcid":"https://orcid.org/0000-0002-3397-1378","observed_orcids":["https://orcid.org/0000-0002-3397-1378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087834980","display_name":"Yutaka Okumura","orcid":"https://orcid.org/0000-0003-2750-3081","observed_orcids":["https://orcid.org/0000-0003-2750-3081"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Okumura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9253,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.77298154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"18","issue":"1A","first_page":"321","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/mutant-p53","display_name":"mutant p53","score":0.8899999856948853},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.7940000295639038},{"id":"https://openalex.org/keywords/nimustine","display_name":"ACNU","score":0.8600000143051147},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.996999979019165},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.7889999747276306},{"id":"https://openalex.org/keywords/saos-2-cells","display_name":"Saos-2 cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.9022974967956543},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.8341562151908875},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6999362707138062},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.6787691712379456},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.601118266582489},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5990774631500244},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5431051254272461},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5398634076118469},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4677709937095642},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4026256203651428},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14972513914108276},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.13386136293411255}],"mesh":[{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015376","descriptor_name":"Nimustine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9568097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9568097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2410169484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9568097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2096204268","https://openalex.org/W1972629085","https://openalex.org/W2091024920","https://openalex.org/W2401810070","https://openalex.org/W7030216031","https://openalex.org/W212115807","https://openalex.org/W2023289001","https://openalex.org/W2187854211","https://openalex.org/W2238526648","https://openalex.org/W2095848435"],"abstract_inverted_index":{"A":[0],"human":[1],"osteosarcoma":[2],"cell":[3],"line,":[4],"Saos-2,":[5],"which":[6,18],"is":[7],"devoid":[8],"of":[9,15,59,75,82,99,103,114,130,135,146],"endogenous":[10],"p53":[11,24,27,86,148],"gene,":[12],"and":[13,32,54,64,87,127],"clones":[14],"Saos-2":[16,126],"cells,":[17],"were":[19,34,66,90],"transfected":[20],"with":[21,42,142],"wild":[22,84],"type":[23,85],"or":[25],"mutant":[26,61,88,104],"genes":[28],"(123A,":[29],"143A,":[30,62],"175H":[31,63],"273H),":[33],"observed":[35],"for":[36],"their":[37],"surviving":[38],"fraction":[39],"after":[40],"treatment":[41],"the":[43,60,73,83,97,112,133,136,143,147],"commonly":[44],"used":[45],"anticancer":[46,139],"drugs,":[47],"cisplatin":[48],"(CDDP),":[49],"nimustine":[50],"(ACNU),":[51],"adriamicin":[52],"(ADR)":[53],"bleomicin":[55],"(BLM).":[56],"The":[57,80,101],"transfectants":[58,81],"273H":[65],"significantly":[67,91],"more":[68,92,107],"resistant":[69],"to":[70,94,109,123,138],"CDDP":[71],"than":[72,96,111],"transfectant":[74,98,102,113],"pOPI3":[76],"(expression":[77],"plasmid":[78],"only).":[79],"123A":[89,105],"sensitive":[93,108],"ACNU":[95],"pOPI3.":[100,115],"was":[106,117],"ADR":[110],"There":[116],"no":[118],"significant":[119],"difference":[120],"in":[121],"sensitivity":[122,134],"BLM":[124],"between":[125],"all":[128],"kinds":[129],"transfectants.":[131],"Thus":[132],"cells":[137],"drugs":[140],"varied":[141],"mutation":[144],"point":[145],"gene.":[149]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
