{"id":"https://openalex.org/W2410165503","doi":"https://doi.org/10.1007/978-1-349-06276-8_15","title":"Molecular biology of tyrosine hydroxylase induction","display_name":"Molecular biology of tyrosine hydroxylase induction","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W2410165503","doi":"https://doi.org/10.1007/978-1-349-06276-8_15","mag":"2410165503"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-349-06276-8_15","doi":"https://doi.org/10.1007/978-1-349-06276-8_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-349-06276-8_15","pdf_url":null,"source":{"id":"https://openalex.org/S4306463716","display_name":"Palgrave Macmillan UK eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319703","host_organization_name":"Palgrave Macmillan","host_organization_lineage":["https://openalex.org/P4310319703","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Palgrave Macmillan","Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2485617923","display_name":"Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048825104","display_name":"Alessandro Guidotti","orcid":"https://orcid.org/0000-0003-4480-0010","observed_orcids":["https://orcid.org/0000-0003-4480-0010"]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Guidotti","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health Saint Elizabeths Hospital, Washington, DC 20032, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health Saint Elizabeths Hospital, Washington, DC 20032, United Kingdom","institution_ids":["https://openalex.org/I2802104953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113535502","display_name":"D M Chuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D M Chuang","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health Saint Elizabeths Hospital, Washington, DC 20032, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health Saint Elizabeths Hospital, Washington, DC 20032, United Kingdom","institution_ids":["https://openalex.org/I2802104953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109043637","display_name":"K. Kumakura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Kumakura","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health Saint Elizabeths Hospital, Washington, DC 20032, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health Saint Elizabeths Hospital, Washington, DC 20032, United Kingdom","institution_ids":["https://openalex.org/I2802104953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051515082","display_name":"E. Costa","orcid":"https://orcid.org/0000-0003-0792-5439","observed_orcids":["https://orcid.org/0000-0003-0792-5439"]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Costa","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health Saint Elizabeths Hospital, Washington, DC 20032, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health Saint Elizabeths Hospital, Washington, DC 20032, United Kingdom","institution_ids":["https://openalex.org/I2802104953"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802104953"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32598039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"141","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.061000000685453415,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.05530000105500221,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.6970000267028809},{"id":"https://openalex.org/keywords/chromaffin-cells","display_name":"chromaffin cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/adrenal-medulla","display_name":"adrenal medulla","score":0.8560000061988831},{"id":"https://openalex.org/keywords/acetylcholine-release","display_name":"acetylcholine release","score":0.9150000214576721},{"id":"https://openalex.org/keywords/catecholamine-biosynthesis","display_name":"catecholamine synthesis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/trans-synaptic-signaling","display_name":"trans-synaptic signaling","score":0.7229999899864197},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/enzyme-induction","display_name":"enzyme induction","score":0.5220000147819519},{"id":"https://openalex.org/keywords/afferent-innervation","display_name":"afferent innervation","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.9045655727386475},{"id":"https://openalex.org/C2777597313","wikidata":"https://www.wikidata.org/wiki/Q934888","display_name":"Adrenal medulla","level":3,"score":0.7214996814727783},{"id":"https://openalex.org/C2909129545","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine 3-Monooxygenase","level":4,"score":0.5821637511253357},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5134842991828918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5039727091789246},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45734477043151855},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.43054690957069397},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.37090030312538147},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31431853771209717},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.26861339807510376},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2222692370414734}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-349-06276-8_15","doi":"https://doi.org/10.1007/978-1-349-06276-8_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-349-06276-8_15","pdf_url":null,"source":{"id":"https://openalex.org/S4306463716","display_name":"Palgrave Macmillan UK eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319703","host_organization_name":"Palgrave Macmillan","host_organization_lineage":["https://openalex.org/P4310319703","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Palgrave Macmillan","Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W988868760","https://openalex.org/W2009251383","https://openalex.org/W2055719149","https://openalex.org/W2064215179","https://openalex.org/W2072904661","https://openalex.org/W2109608980","https://openalex.org/W2312029842","https://openalex.org/W2410725625","https://openalex.org/W2413772162","https://openalex.org/W4406988036"],"related_works":["https://openalex.org/W248674206","https://openalex.org/W2078552350","https://openalex.org/W2493843344","https://openalex.org/W1995978652","https://openalex.org/W1995739691","https://openalex.org/W2066567786","https://openalex.org/W2396112225","https://openalex.org/W272282084","https://openalex.org/W1969669997","https://openalex.org/W2061241408"],"abstract_inverted_index":{"Several":[0],"lines":[1],"of":[2,10,35,73,93,107,110],"investigation":[3],"have":[4],"suggested":[5],"that":[6],"the":[7,16,70,91,108,122,129,135],"persistent":[8],"release":[9],"acetylcholine":[11],"from":[12],"axon":[13],"terminals":[14],"innervating":[15],"rat":[17],"adrenal":[18],"medulla":[19],"activates":[20],"nicotinic":[21],"receptors":[22],"located":[23],"in":[24,81,103],"chromaffin":[25],"cells":[26],"and":[27,40,44,101,119,128],"induces":[28],"tyrosine":[29],"hydroxylase":[30],"(TH)":[31],"after":[32],"a":[33,66,82,94],"period":[34],"latency":[36],"(Axelrod,":[37],"1971;":[38,42],"Patrick":[39],"Kirshner,":[41],"Guidotti":[43],"Costa,":[45],"1973).":[46],"Although":[47],"originally":[48],"these":[49],"studies":[50],"were":[51,115],"carried":[52],"out":[53],"to":[54,68,96],"investigate":[55],"how":[56],"afferent":[57],"impulses":[58],"control":[59],"catecholamine":[60],"biosynthesis,":[61],"subsequently":[62],"this":[63],"induction":[64],"became":[65],"model":[67],"study":[69],"causal":[71],"sequence":[72,88],"molecular":[74],"events":[75],"whereby":[76],"enzymes":[77],"can":[78],"be":[79,132],"induced":[80],"cell":[83],"by":[84,117,121],"transsynaptic":[85],"stimuli.":[86],"This":[87,124],"begins":[89],"with":[90],"binding":[92],"transmitter":[95],"its":[97],"specific":[98],"membrane":[99],"receptor":[100],"ends":[102],"functionally":[104],"relevant":[105],"modifications":[106],"expression":[109],"gene":[111],"activity.":[112],"These":[113],"keywords":[114,130],"added":[116],"machine":[118],"not":[120],"authors.":[123],"process":[125],"is":[126],"experimental":[127],"may":[131],"updated":[133],"as":[134],"learning":[136],"algorithm":[137],"improves.":[138]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}