{"id":"https://openalex.org/W2410117005","doi":null,"title":"Influence of supplementation with N-3 fatty acids on different coronary risk factors in men--a placebo controlled study.","display_name":"Influence of supplementation with N-3 fatty acids on different coronary risk factors in men--a placebo controlled study.","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2410117005","mag":"2410117005","pmid":"https://pubmed.ncbi.nlm.nih.gov/1413984"},"language":"en","primary_location":{"id":"pmid:1413984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1413984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112149024","display_name":"Jean Paul Deslypere","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"J P Deslypere","raw_affiliation_strings":["Department of Endocrinology, University Hospital, Gent"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, University Hospital, Gent","institution_ids":["https://openalex.org/I2801227569"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112149024"],"corresponding_institution_ids":["https://openalex.org/I2801227569"],"apc_list":null,"apc_paid":null,"fwci":0.867,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.73306462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"54","issue":"3","first_page":"189","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10450","display_name":"Aquaculture Nutrition and Growth","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9480000138282776},{"id":"https://openalex.org/keywords/fish-oil-supplementation","display_name":"fish oil supplementation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/coronary-risk-factors","display_name":"coronary risk factors","score":0.8259999752044678},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9620000123977661},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.8820000290870667},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.5929999947547913},{"id":"https://openalex.org/keywords/coagulation-and-fibrinolysis","display_name":"coagulation and fibrinolysis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7250000238418579},{"id":"https://openalex.org/keywords/men","display_name":"men","score":0.3070000112056732},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2779946292","wikidata":"https://www.wikidata.org/wiki/Q1786125","display_name":"Fish oil","level":3,"score":0.7465502619743347},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.6636512875556946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5983706116676331},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5800788998603821},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5701976418495178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5611791014671326},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.5464091300964355},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.536323070526123},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.45882630348205566},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45034146308898926},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.44707199931144714},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.43398359417915344},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.41801396012306213},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4115149974822998},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38575106859207153},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.333057165145874},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.32404887676239014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19543898105621338},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.149433434009552},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.12545746564865112},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08740872144699097},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015525","descriptor_name":"Fatty Acids, Omega-3","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015525","descriptor_name":"Fatty Acids, Omega-3","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:1413984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1413984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie","raw_type":"Clinical Trial"},{"id":"pmh:oai:archive.ugent.be:233898","doi":null,"is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/233898","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0302-6469","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2410117005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1413984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2143392703","https://openalex.org/W2421071080","https://openalex.org/W3014769807","https://openalex.org/W2767751524","https://openalex.org/W2088047127","https://openalex.org/W2204737926","https://openalex.org/W4251357218","https://openalex.org/W191717173","https://openalex.org/W2138965761","https://openalex.org/W4300097062"],"abstract_inverted_index":{"Recent":[0],"epidemiological":[1],"studies":[2,26,71],"have":[3,33,106],"shown":[4],"some":[5],"beneficial":[6,62],"health":[7],"effects":[8,41,63],"of":[9,24,42,54,60,64,91,141,189,201,216,221,230,247],"the":[10,22,40,48,55,61,121,208,214,219,227,237,244,256,294],"long":[11],"chain":[12],"(n-3)":[13],"polyunsaturated":[14],"fatty":[15,19,44],"acids":[16,45],"found":[17],"in":[18,69,77,103,114,207,218,265,293],"fish.":[20],"Although":[21],"results":[23],"these":[25,231],"are":[27],"often":[28],"ambiguous":[29],"and":[30,97,102,128,168,285],"inconclusive,":[31],"they":[32],"prompted":[34],"many":[35,59],"intervention":[36,70],"trials":[37],"to":[38,105,252],"study":[39,111],"n-3":[43,100,142,248,283],"(FA)":[46],"on":[47,145,173,177,255,274],"cardiovascular":[49],"risk":[50],"profile.":[51],"However":[52],"screening":[53],"literature":[56],"revealed":[57],"that":[58,243],"fish":[65,122,210],"(oil)":[66],"were":[67,129],"obtained":[68],"which":[72,278,286],"had":[73],"several":[74],"serious":[75],"shortcomings":[76],"their":[78],"design.":[79],"Therefore":[80],"we":[81],"started":[82],"a":[83,107,195],"placebo":[84],"controlled":[85],"randomised":[86],"trial":[87],"with":[88],"increasing":[89],"doses":[90],"n-3FA":[92],"(respectively":[93],"0;":[94],"1.12;":[95],"2.24":[96],"3.37":[98],"g":[99],"FA/day)":[101],"order":[104],"maximum":[108],"compliance":[109],"this":[110],"was":[112,192,205],"done":[113],"healthy":[115],"monks.":[116],"Fifty":[117],"eight":[118],"subjects":[119],"took":[120],"oil":[123,211],"capsules":[124],"during":[125],"12":[126],"months":[127],"thereafter":[130],"followed":[131],"for":[132],"another":[133],"6":[134],"months.":[135],"We":[136],"couldn't":[137],"detect":[138],"any":[139],"effect":[140,254],"FA":[143,249,284],"supplementation":[144],"total":[146],"cholesterol,":[147,149,151],"HDL":[148],"LDL":[150],"apo":[152,202],"A1,":[153],"Lp(a),":[154],"HbA1C,":[155],"glucose,":[156],"fibrinogen,":[157],"factor":[158,171],"VIII,":[159],"antithrombin":[160],"III,":[161],"plasminogen":[162,166],"activator":[163,167],"inhibitor,":[164],"tissue":[165],"von":[169],"Willebrand":[170],"concentration,":[172],"bleeding":[174],"time":[175],"or":[176,179,260],"systolic":[178],"diastolic":[180],"blood":[181],"pressure.":[182],"A":[183],"pronounced":[184],"significant":[185,199],"dose":[186],"dependent":[187],"decrease":[188,200],"triglyceride":[190],"levels":[191,204],"seen,":[193],"while":[194],"slight":[196],"but":[197],"statistical":[198],"B":[203],"observed":[206],"highest":[209],"dose.":[212],"As":[213],"importance":[215],"triglycerides":[217],"pathogenesis":[220],"atherosclerosis":[222],"is":[223,233,250],"still":[224],"under":[225],"discussion,":[226],"clinical":[228],"relevance":[229],"finding":[232],"not":[234],"clear":[235],"at":[236],"moment.":[238],"It":[239],"seems":[240],"therefore":[241],"improbable":[242],"anti-atherosclerotic":[245],"action":[246],"due":[251],"an":[253,289],"lipid,":[257],"apoprotein,":[258],"coagulation":[259],"fibrinolysis":[261],"parameters":[262,276],"as":[263],"measured":[264],"our":[266],"study.":[267],"Hence":[268],"further":[269],"research":[270],"must":[271],"be":[272,280],"focused":[273],"other":[275],"(prostaglandins)":[277],"can":[279],"influenced":[281],"by":[282],"probably":[287],"play":[288],"equally":[290],"important":[291],"role":[292],"atherosclerotic":[295],"process.":[296]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
