{"id":"https://openalex.org/W2410098307","doi":null,"title":"[Current role of metformin in treatment of diabetes mellitus type 2].","display_name":"[Current role of metformin in treatment of diabetes mellitus type 2].","publication_year":2000,"publication_date":"2000-09-30","ids":{"openalex":"https://openalex.org/W2410098307","mag":"2410098307","pmid":"https://pubmed.ncbi.nlm.nih.gov/11045135"},"language":"nl","primary_location":{"id":"pmid:11045135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11045135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nederlands tijdschrift voor geneeskunde","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026436166","display_name":"J. A. M. J. L. Janssen","orcid":"https://orcid.org/0000-0002-9363-6408","observed_orcids":["https://orcid.org/0000-0002-9363-6408"]},"institutions":[{"id":"https://openalex.org/I4405267036","display_name":"Academisch Ziekenhuis Rotterdam","ror":"https://ror.org/00xtwy257","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4405267036"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"J A Janssen","raw_affiliation_strings":["Afd. Interne Geneeskunde, Academisch Ziekenhuis Rotterdam-Dijkzigt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Afd. Interne Geneeskunde, Academisch Ziekenhuis Rotterdam-Dijkzigt","institution_ids":["https://openalex.org/I4405267036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026436166"],"corresponding_institution_ids":["https://openalex.org/I4405267036"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"40","first_page":"1900","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/metformin-associated-lactic-acidosis","display_name":"metformin-associated lactic acidosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ukpds","display_name":"UKPDS","score":0.8119999766349792},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8299999833106995},{"id":"https://openalex.org/keywords/microvascular-complications","display_name":"microvascular complications","score":0.8799999952316284},{"id":"https://openalex.org/keywords/macrovascular-events","display_name":"macrovascular events","score":0.8849999904632568},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9070000052452087},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.9855555891990662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9552469253540039},{"id":"https://openalex.org/C2778854520","wikidata":"https://www.wikidata.org/wiki/Q418776","display_name":"Sulfonylurea","level":3,"score":0.8371416926383972},{"id":"https://openalex.org/C2780317664","wikidata":"https://www.wikidata.org/wiki/Q1500373","display_name":"Lactic acidosis","level":2,"score":0.8019473552703857},{"id":"https://openalex.org/C2780920962","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"United Kingdom Prospective Diabetes Study","level":4,"score":0.7428935766220093},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.7261163592338562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6721347570419312},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6608827710151672},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4520558714866638},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3803432881832123}],"mesh":[{"descriptor_ui":"D000075202","descriptor_name":"Contraindications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000140","descriptor_name":"Acidosis, Lactic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11045135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11045135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nederlands tijdschrift voor geneeskunde","raw_type":"Journal Article"},{"id":"mag:2410098307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11045135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4256180260","https://openalex.org/W2144330800","https://openalex.org/W2412345970","https://openalex.org/W2067068390","https://openalex.org/W2549172675","https://openalex.org/W7097727584","https://openalex.org/W2020741797","https://openalex.org/W3185842985","https://openalex.org/W2801542522","https://openalex.org/W4292620874"],"abstract_inverted_index":{"Metformin-associated":[0],"lactic":[1,20],"acidosis":[2,21],"is":[3,22,160,171,202,222],"not":[4,223],"necessarily":[5],"due":[6],"to":[7,25,106,121,167,182,192,203,212],"metformin":[8,17,33,49,93,100,210],"accumulation.":[9],"It":[10,28],"appears":[11],"that":[12,32,161],"mortality":[13,64,116],"in":[14,56,65,73,77,83,88,101,117,130,184],"patients":[15,47,133],"receiving":[16],"who":[18,190],"develop":[19],"mostly":[23],"linked":[24],"underlying":[26],"disease.":[27],"has":[29],"been":[30],"suggested":[31],"should":[34],"be":[35,107],"the":[36,40,66,97,122,128,131,139,158,164,168,175,218],"first-line":[37],"agent":[38,177,216],"for":[39,144,147],"treatment":[41],"of":[42,62,99,112,127,137,150,157,163,174],"obese":[43,89,118,132],"type":[44,151,186],"2":[45,152,187],"diabetic":[46],"since":[48],"was":[50,86],"associated":[51,108],"with":[52,91,103,109,197,206],"a":[53,60,74,135,185,207],"significant":[54,81],"decrease":[55,82],"macrovascular":[57],"events":[58],"and":[59,114,124,134,199,211],"reduction":[61],"all-cause":[63,115],"United":[67],"Kingdom":[68],"Prospective":[69],"Diabetes":[70],"Study":[71],"(UKPDS)":[72],"substudy.":[75],"However,":[76],"this":[78],"substudy":[79],"no":[80,142],"microvascular":[84],"complications":[85],"observed":[87],"subjects":[90],"intensive":[92],"therapy.":[94],"In":[95],"addition,":[96],"use":[98],"combination":[102],"sulfonylurea":[104,208],"seemed":[105],"excess":[110],"risk":[111],"diabetes-related":[113],"subjects.":[119],"Due":[120],"discrepant":[123],"contradictory":[125],"nature":[126],"results":[129],"lack":[136],"power":[138],"UKPDS":[140,159],"offered":[141],"decision":[143],"any":[145],"drug":[146],"initial":[148],"therapy":[149,183,205],"diabetes.":[153],"The":[154],"main":[155],"message":[156],"lowering":[162],"blood":[165,195],"glucose":[166],"normal":[169],"range":[170],"beneficial":[172],"irrespective":[173],"hypoglycaemic":[176],"used.":[178],"A":[179],"rational":[180],"approach":[181],"diabetes":[188],"patient":[189],"fails":[191],"sufficiently":[193],"lower":[194],"sugar":[196],"diet":[198],"weight":[200],"loss":[201],"begin":[204],"or":[209],"add":[213],"another":[214],"oral":[215],"if":[217],"desired":[219],"glycaemic":[220],"control":[221],"achieved.":[224]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}