{"id":"https://openalex.org/W2410072590","doi":null,"title":"Neuropathic cancer pain: the role of adjuvant analgesics.","display_name":"Neuropathic cancer pain: the role of adjuvant analgesics.","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2410072590","mag":"2410072590","pmid":"https://pubmed.ncbi.nlm.nih.gov/11758872"},"language":"en","primary_location":{"id":"pmid:11758872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11758872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology (Williston Park, N.Y.)","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085578019","display_name":"John T. Farrar","orcid":"https://orcid.org/0000-0001-8656-5157","observed_orcids":["https://orcid.org/0000-0001-8656-5157"]},"institutions":[{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J T Farrar","raw_affiliation_strings":["Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Health System, Philadelphia 19104-6021, USA. jfarrar@cceb.med.upenn.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Health System, Philadelphia 19104-6021, USA. jfarrar@cceb.med.upenn.edu","institution_ids":["https://openalex.org/I4210143392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055802027","display_name":"R. Portenoy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R K Portenoy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.587,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.94631321,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"15","issue":"11","first_page":"1435","last_page":"42, 1445; discussion 1445, 1450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropathic-cancer-pain","display_name":"neuropathic cancer pain","score":0.9279999732971191},{"id":"https://openalex.org/keywords/adjuvant-analgesics","display_name":"adjuvant analgesics","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.859000027179718},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9279999732971191},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.9959999918937683},{"id":"https://openalex.org/keywords/opioid-analgesics","display_name":"opioid analgesics","score":0.7110000252723694},{"id":"https://openalex.org/keywords/chemotherapy-induced-peripheral-neuropathy","display_name":"chemotherapy-induced peripheral neuropathy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/nerve-compression","display_name":"nerve compression","score":0.47600001096725464},{"id":"https://openalex.org/keywords/spinal-cord-compression","display_name":"spinal cord compression","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.8944259881973267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.887701153755188},{"id":"https://openalex.org/C2776608144","wikidata":"https://www.wikidata.org/wiki/Q410352","display_name":"Gabapentin","level":3,"score":0.5338360667228699},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5165494680404663},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.5110756158828735},{"id":"https://openalex.org/C2775991916","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Nerve injury","level":2,"score":0.5031031966209412},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49191856384277344},{"id":"https://openalex.org/C2778904085","wikidata":"https://www.wikidata.org/wiki/Q3712728","display_name":"Cancer pain","level":3,"score":0.4784379303455353},{"id":"https://openalex.org/C55932262","wikidata":"https://www.wikidata.org/wiki/Q7827726","display_name":"Pain ladder","level":4,"score":0.47680899500846863},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.4607663154602051},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.4558703601360321},{"id":"https://openalex.org/C2780016216","wikidata":"https://www.wikidata.org/wiki/Q1136940","display_name":"Neuralgia","level":3,"score":0.4243064522743225},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3760378062725067},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18694299459457397},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1100885272026062},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11758872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11758872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology (Williston Park, N.Y.)","raw_type":"Journal Article"},{"id":"mag:2410072590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11758872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2396765387","https://openalex.org/W4232469931","https://openalex.org/W2417231127","https://openalex.org/W4388358207","https://openalex.org/W4224138878","https://openalex.org/W169170251","https://openalex.org/W2741839242","https://openalex.org/W2071508903","https://openalex.org/W4401777140","https://openalex.org/W2245623237"],"abstract_inverted_index":{"Neuropathic":[0],"pain":[1,6,84,110],"may":[2],"be":[3,163],"defined":[4],"as":[5],"related":[7,87],"to":[8,36,61,88,101,125],"abnormal":[9],"somatosensory":[10],"processing":[11],"in":[12,111,152],"either":[13],"the":[14,27,80,94],"peripheral":[15,95],"or":[16,45,53,97,100,120],"central":[17],"nervous":[18],"system.":[19],"This":[20],"pathophysiologic":[21],"label":[22],"is":[23,30,39,85],"typically":[24],"applied":[25],"when":[26],"painful":[28],"symptom":[29],"associated":[31],"with":[32,154],"an":[33],"overt":[34],"injury":[35,57,74],"neural":[37,56],"structures,":[38],"part":[40],"of":[41,72,93,142],"a":[42,47,69,102,139],"recognized":[43],"syndrome,":[44],"has":[46],"dysesthetic":[48],"quality":[49],"(usually":[50],"burning,":[51],"shooting,":[52],"electrical).":[54],"Most":[55],"does":[58],"not":[59],"lead":[60],"clinically":[62],"important":[63],"neuropathic":[64,83,109,155],"pain,":[65,156],"but":[66,138],"sometimes":[67],"even":[68],"small":[70],"degree":[71],"tissue":[73],"can":[75],"precipitate":[76],"severe":[77],"pain.":[78],"In":[79],"cancer":[81],"population,":[82,113],"often":[86,123],"compression,":[89],"direct":[90],"neoplastic":[91],"invasion":[92],"nerves":[96],"spinal":[98],"cord,":[99],"neuropathy":[103],"caused":[104],"by":[105],"chemotherapy.":[106],"To":[107,148],"manage":[108],"this":[112],"nonopioid":[114],"adjuvant":[115,131,160],"drugs":[116,144],"that":[117],"are":[118,122,133,145],"neuroactive":[119],"neuromodulatory":[121],"needed":[124],"complement":[126],"opioid":[127,158],"therapy.":[128],"The":[129],"primary":[130],"analgesics":[132,161],"anticonvulsant":[134],"and":[135,159],"antidepressant":[136],"medications,":[137],"wide":[140],"variety":[141],"other":[143],"also":[146],"used.":[147],"optimize":[149],"analgesic":[150],"therapy":[151],"patients":[153],"both":[157],"must":[162],"used":[164],"effectively.":[165]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}