{"id":"https://openalex.org/W2410071986","doi":"https://doi.org/10.1242/jeb.172.1.39","title":"The importance of being acid: the role of acidification in intracellular membrane traffic","display_name":"The importance of being acid: the role of acidification in intracellular membrane traffic","publication_year":1992,"publication_date":"1992-11-01","ids":{"openalex":"https://openalex.org/W2410071986","doi":"https://doi.org/10.1242/jeb.172.1.39","mag":"2410071986","pmid":"https://pubmed.ncbi.nlm.nih.gov/1491231"},"language":"en","primary_location":{"id":"doi:10.1242/jeb.172.1.39","doi":"https://doi.org/10.1242/jeb.172.1.39","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jeb.172.1.39","pdf_url":null,"source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2410071986"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085574965","display_name":"Ira Mellman","orcid":"https://orcid.org/0000-0002-6132-7299","observed_orcids":["https://orcid.org/0000-0002-6132-7299"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ira Mellman","raw_affiliation_strings":["Yale University School of Medicine Department of Cell Biology , , 333 Cedar Street, PO Box 3333, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine Department of Cell Biology , , 333 Cedar Street, PO Box 3333, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085574965"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":1.3925,"has_fulltext":false,"cited_by_count":190,"citation_normalized_percentile":{"value":0.79041916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"172","issue":"1","first_page":"39","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular-acidification","display_name":"intracellular acidification","score":0.7490000128746033},{"id":"https://openalex.org/keywords/membrane-traffic","display_name":"membrane traffic","score":0.652999997138977},{"id":"https://openalex.org/keywords/vacuolar-ph","display_name":"vacuolar pH","score":0.8659999966621399},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.875},{"id":"https://openalex.org/keywords/phagolysosomes","display_name":"phagolysosomes","score":0.7450000047683716},{"id":"https://openalex.org/keywords/proton-pump","display_name":"proton pump","score":0.8309999704360962},{"id":"https://openalex.org/keywords/metchnikoff","display_name":"Metchnikoff","score":0.7319999933242798},{"id":"https://openalex.org/keywords/neutral-red","display_name":"neutral red","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.7699027061462402},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7230748534202576},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6958985328674316},{"id":"https://openalex.org/C134897140","wikidata":"https://www.wikidata.org/wiki/Q6058355","display_name":"Intracellular pH","level":3,"score":0.6654682755470276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4965394139289856},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4788122773170471},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4655163288116455},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4253040552139282},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3760877251625061},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3564947843551636}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015388","descriptor_name":"Organelles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025262","descriptor_name":"Vacuolar Proton-Translocating ATPases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1242/jeb.172.1.39","doi":"https://doi.org/10.1242/jeb.172.1.39","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jeb.172.1.39","pdf_url":null,"source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},{"id":"pmid:1491231","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1491231","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.830.5709","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.830.5709","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jeb.biologists.org/content/jexbio/172/1/39.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1520733676","https://openalex.org/W1566236542","https://openalex.org/W2006585409","https://openalex.org/W2014490182","https://openalex.org/W2024107744","https://openalex.org/W2032850298","https://openalex.org/W2065378127","https://openalex.org/W2075507579","https://openalex.org/W2078194494","https://openalex.org/W2106448340","https://openalex.org/W2114001610","https://openalex.org/W2123124320","https://openalex.org/W2140596567","https://openalex.org/W2174160083"],"related_works":["https://openalex.org/W4236067813","https://openalex.org/W1989363022","https://openalex.org/W18387138","https://openalex.org/W1535569627","https://openalex.org/W4211208107","https://openalex.org/W56587513","https://openalex.org/W186061623","https://openalex.org/W4410415564","https://openalex.org/W1900660557","https://openalex.org/W7100526350"],"abstract_inverted_index":{"ABSTRACT":[0],"Ever":[1],"since":[2],"the":[3,10,13,20,64,73,95,104,111,115,118,128],"early":[4],"work":[5],"of":[6,12,22,37,44,63,84,97,106,130,147],"Elie":[7],"Metchnikoff":[8,55,90,148],"at":[9],"turn":[11],"century,":[14],"it":[15],"has":[16],"been":[17,140],"clear":[18],"that":[19,57,117],"ability":[21],"vacuolar":[23],"organelles":[24,86],"to":[25,69,122,127],"generate":[26],"and":[27,76,114],"maintain":[28],"pH":[29,46],"plays":[30],"a":[31,35,42],"crucial":[32],"role":[33,105],"in":[34,72,109,138],"variety":[36,43],"critical":[38],"cellular":[39,107],"functions.":[40],"Using":[41],"crude":[45],"indicators":[47],"such":[48,133],"as":[49,125,134,142],"neutral":[50],"red":[51],"or":[52,82,87],"litmus":[53],"particles,":[54],"observed":[56],"bacteria":[58],"ingested":[59],"by":[60,145],"phagocytic":[61],"cells":[62],"immune":[65],"system":[66],"were":[67],"transferred":[68],"acidic":[70,99,112,131],"structures":[71],"cytoplasm,":[74],"killed":[75],"then":[77],"digested.":[78],"Without":[79],"any":[80],"understanding":[81],"knowledge":[83],"membranes,":[85],"proton":[88],"pumps,":[89],"drew":[91],"accurate":[92],"conclusions":[93],"concerning":[94],"necessity":[96],"an":[98,143],"milieu":[100],"for":[101],"intracellular":[102],"digestion,":[103],"energy":[108],"maintaining":[110],"pH,":[113],"likelihood":[116],"acidity":[119],"was":[120],"due":[121],"diffusible":[123],"protons":[124],"opposed":[126],"infusion":[129],"substances":[132],"DNA":[135],"(which":[136],"had,":[137],"fact,":[139],"offered":[141],"explanation":[144],"some":[146],"s":[149],"contemporaries).":[150]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
