{"id":"https://openalex.org/W2410061579","doi":null,"title":"Characterization of polyethylene glycol-modified L-asparaginase from Escherichia coli and its application to therapy of leukemia.","display_name":"Characterization of polyethylene glycol-modified L-asparaginase from Escherichia coli and its application to therapy of leukemia.","publication_year":1986,"publication_date":"1986-12-01","ids":{"openalex":"https://openalex.org/W2410061579","mag":"2410061579","pmid":"https://pubmed.ncbi.nlm.nih.gov/3102431"},"language":"en","primary_location":{"id":"pmid:3102431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3102431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001884814","display_name":"Takayuki Yoshimoto","orcid":"https://orcid.org/0000-0002-2847-0341","observed_orcids":["https://orcid.org/0000-0002-2847-0341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Yoshimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Nishimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Nishimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079583545","display_name":"Yuji Saito","orcid":"https://orcid.org/0000-0003-2804-8076","observed_orcids":["https://orcid.org/0000-0003-2804-8076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Saito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Sakurai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Sakurai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111529737","display_name":"Yoshinori Kamisaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Kamisaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Wada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Wada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024186794","display_name":"Makoto Sako","orcid":"https://orcid.org/0000-0002-4268-7002","observed_orcids":["https://orcid.org/0000-0002-4268-7002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Sako","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083701314","display_name":"Giiti Tsujino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Tsujino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Y Inada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Inada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3673,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.55192034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"77","issue":"12","first_page":"1264","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.1875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.1875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.17880000174045563,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.1664000004529953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-asparaginase","display_name":"L-asparaginase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8399999737739563},{"id":"https://openalex.org/keywords/polyethylene-glycol-modification","display_name":"polyethylene glycol modification","score":0.8820000290870667},{"id":"https://openalex.org/keywords/enzyme-conjugation","display_name":"enzyme conjugation","score":0.4699999988079071},{"id":"https://openalex.org/keywords/lymphosarcoma","display_name":"lymphosarcoma","score":0.7739999890327454},{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.8640000224113464},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.6399999856948853},{"id":"https://openalex.org/keywords/anaphylactic-shock","display_name":"anaphylactic shock","score":0.7689999938011169},{"id":"https://openalex.org/keywords/enzyme-stability","display_name":"enzyme stability","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C2778904437","wikidata":"https://www.wikidata.org/wiki/Q105296036","display_name":"Asparaginase","level":4,"score":0.8424803018569946},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.600619912147522},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.5975475907325745},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.5549691319465637},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5044528245925903},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5004861354827881},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4579036235809326},{"id":"https://openalex.org/C2779149719","wikidata":"https://www.wikidata.org/wiki/Q682252","display_name":"PEGylation","level":3,"score":0.4377523958683014},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42690667510032654},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4244951605796814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40191221237182617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36024969816207886},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3314563035964966},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2770747244358063},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.19636815786361694},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001215","descriptor_name":"Asparaginase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3102431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3102431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Journal Article"},{"id":"mag:2410061579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3102431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2437485144","https://openalex.org/W2376397281","https://openalex.org/W2150187179","https://openalex.org/W1821438013","https://openalex.org/W2003347051","https://openalex.org/W7098877247","https://openalex.org/W2356447284","https://openalex.org/W2030245504","https://openalex.org/W2078263947","https://openalex.org/W1963647288"],"abstract_inverted_index":{"For":[0],"the":[1,7,51,55,64,73,76,82,91,98,145,148],"purpose":[2],"of":[3,9,34,48,50,54,75,81,86,97,120,128,130,136,151],"clinical":[4],"application":[5],"to":[6,101,144,154],"therapy":[8],"human":[10],"leukemia":[11,122],"and":[12,84,88,90,132],"lymphosarcoma,":[13],"L-asparaginase":[14],"from":[15],"Escherichia":[16],"coli":[17],"was":[18,158],"modified":[19,70,99],"with":[20,104,117,125],"2,4-bis(O-methoxypolyethylene":[21],"glycol)-6-chloro-s-triazine":[22],"(activated":[23],"PEG2)":[24],"by":[25,37],"an":[26],"improved":[27],"method,":[28],"which":[29],"involves":[30],"a":[31,102,126],"purification":[32],"step":[33],"activated":[35],"PEG2":[36],"gel":[38],"filtration.":[39],"The":[40,69],"PEG2-modified":[41,152],"asparaginase":[42,153],"retained":[43,72],"approximately":[44],"30%":[45],"(73":[46],"IU/mg":[47],"protein)":[49],"enzymic":[52],"activity":[53,87],"native":[56,77,133,146],"enzyme,":[57,147],"while":[58],"it":[59],"had":[60],"almost":[61],"wholly":[62],"lost":[63],"immunoreactivity":[65],"towards":[66],"anti-asparaginase":[67],"antibodies.":[68],"enzyme":[71,78,100],"characteristics":[74],"in":[79],"terms":[80],"pH-":[83],"temperature-dependencies":[85],"stability,":[89],"Km":[92],"value":[93],"for":[94],"L-asparagine.":[95],"Administration":[96],"dog":[103],"spontaneous":[105],"lymphosarcoma":[106],"induced":[107],"complete":[108],"remission":[109],"without":[110,161],"any":[111,163],"toxic":[112],"side":[113],"effects.":[114],"Seven":[115],"children":[116,138],"multiple":[118],"relapses":[119],"acute":[121],"were":[123],"treated":[124],"regimen":[127],"cycles":[129],"methotrexate":[131],"asparaginase.":[134],"Three":[135],"these":[137],"developed":[139],"anaphylactic":[140],"shock.":[141],"In":[142],"contrast":[143],"successive":[149],"administration":[150],"those":[155],"three":[156],"patients":[157],"therapeutically":[159],"effective":[160],"causing":[162],"allergic":[164],"reaction.":[165]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
