{"id":"https://openalex.org/W2409964191","doi":null,"title":"Irisin/FNDC5--An updated review.","display_name":"Irisin/FNDC5--An updated review.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2409964191","mag":"2409964191","pmid":"https://pubmed.ncbi.nlm.nih.gov/26957272"},"language":"en","primary_location":{"id":"pmid:26957272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26957272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021683325","display_name":"Kalpana Panati","orcid":"https://orcid.org/0000-0002-0829-0917","observed_orcids":["https://orcid.org/0000-0002-0829-0917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Panati","raw_affiliation_strings":["Department of Biotechnology, Govt. College for Men, Kadapa, AP, India. panatikalpana@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Govt. College for Men, Kadapa, AP, India. panatikalpana@gmail.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y Suneetha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Suneetha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018628879","display_name":"Venkata Ramireddy Narala","orcid":"https://orcid.org/0000-0001-6672-4165","observed_orcids":["https://orcid.org/0000-0001-6672-4165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V R Narala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.353,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.98610658,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"20","issue":"4","first_page":"689","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.12290000170469284,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irisin","display_name":"irisin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fndc5","display_name":"FNDC5","score":0.996999979019165},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7310000061988831},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.7609999775886536},{"id":"https://openalex.org/keywords/white-adipose-tissue-browning","display_name":"white adipose tissue browning","score":0.7940000295639038},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.972000002861023},{"id":"https://openalex.org/keywords/proteolytic-cleavage","display_name":"proteolytic cleavage","score":0.7940000295639038},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/hippocampal-neurogenesis","display_name":"hippocampal neurogenesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9760000109672546},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C206810289","wikidata":"https://www.wikidata.org/wiki/Q21118157","display_name":"FNDC5","level":4,"score":0.9907137155532837},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6682010293006897},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.4932710528373718},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4742385745048523},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4540260434150696},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4068230986595154},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.3814204931259155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36792850494384766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34990838170051575},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3486161231994629},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2971230745315552},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23732832074165344},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.07880759239196777}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:26957272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26957272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2409964191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26957272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2141134985","https://openalex.org/W3124550675","https://openalex.org/W4396228801","https://openalex.org/W3087164138","https://openalex.org/W2811255015","https://openalex.org/W2043265447","https://openalex.org/W2086853203","https://openalex.org/W7097355243","https://openalex.org/W4286511448","https://openalex.org/W4285132943"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,119],"irisin,":[2,127],"recently":[3],"identified":[4],"novel":[5],"molecule,":[6],"has":[7,29],"been":[8,30,76,86],"shown":[9],"to":[10,45,80,110],"be":[11],"secreted":[12],"from":[13,55],"fibronectin":[14],"type":[15],"III":[16],"domain":[17],"containing":[18],"5":[19],"(FNDC5)":[20],"of":[21,126],"skeletal":[22],"muscle":[23],"by":[24],"an":[25,36],"unknown":[26],"protease.":[27],"It":[28,138],"proposed":[31],"that":[32],"this":[33],"molecule":[34],"plays":[35],"important":[37],"role":[38,60,130],"in":[39,61,131],"converting":[40],"the":[41,51,124,141],"white":[42],"adipose":[43,47],"tissue":[44,48],"brown":[46],"and":[49,59,71,133,136,144],"regulating":[50],"energy":[52],"expenditure.":[53],"Apart":[54],"this,":[56],"its":[57,89,128],"expression":[58],"various":[62],"other":[63,72],"conditions":[64,74,135],"such":[65],"as":[66],"inflammation,":[67],"hippocampal":[68],"neurogenesis,":[69],"aging":[70],"metabolic":[73],"have":[75,85],"reported.":[77],"However,":[78],"due":[79],"conflicting":[81],"results,":[82],"several":[83],"issues":[84],"raised":[87],"regarding":[88,114],"expression,":[90],"cleavage,":[91],"circulating":[92],"levels,":[93],"detection,":[94],"excretion,":[95],"designation,":[96],"etc.":[97],"MATERIALS":[98],"AND":[99,117],"METHODS:":[100],"Complete":[101],"literature":[102],"survey":[103],"was":[104],"performed":[105],"using":[106],"PubMed":[107],"database":[108],"search":[109],"gather":[111],"available":[112],"information":[113],"FNDC5/irisin.":[115],"RESULTS":[116],"CONCLUSIONS:":[118],"present":[120],"review":[121],"discussed":[122,140],"on":[123],"discovery":[125],"possible":[129],"physiological":[132],"pathological":[134],"controversies.":[137],"also":[139],"current":[142],"challenges":[143],"future":[145],"perspectives.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
