{"id":"https://openalex.org/W2409953256","doi":null,"title":"Combination effects of chloral hydrate and nitrous oxide/oxygen in the mouse staircase test.","display_name":"Combination effects of chloral hydrate and nitrous oxide/oxygen in the mouse staircase test.","publication_year":1988,"publication_date":"1988-05-01","ids":{"openalex":"https://openalex.org/W2409953256","mag":"2409953256","pmid":"https://pubmed.ncbi.nlm.nih.gov/3166349","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2168025"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2168025","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2168025","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesth Prog","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2168025","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061914408","display_name":"Ronald J. Pruhs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Pruhs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113501842","display_name":"John H. Kalbfleisch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Kalbfleisch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015469925","display_name":"Raymond Mark Quock","orcid":"https://orcid.org/0000-0001-6616-4778","observed_orcids":["https://orcid.org/0000-0001-6616-4778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Quock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6151,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.71668533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"35","issue":"3","first_page":"116","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.10459999740123749,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chloral-hydrate","display_name":"chloral hydrate","score":1.0},{"id":"https://openalex.org/keywords/nitrous-oxide","display_name":"nitrous oxide","score":0.996999979019165},{"id":"https://openalex.org/keywords/oxygen","display_name":"oxygen","score":0.5849999785423279},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.675000011920929},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.5630000233650208},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/rearing-behavior","display_name":"rearing behavior","score":0.7129999995231628},{"id":"https://openalex.org/keywords/staircase-test","display_name":"staircase test","score":0.746999979019165},{"id":"https://openalex.org/keywords/drug-potentiation","display_name":"drug potentiation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/drug-combination-effects","display_name":"drug combination effects","score":0.6129999756813049},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2777612814","wikidata":"https://www.wikidata.org/wiki/Q412340","display_name":"Chloral hydrate","level":2,"score":0.99193274974823},{"id":"https://openalex.org/C2777573673","wikidata":"https://www.wikidata.org/wiki/Q905750","display_name":"Nitrous oxide","level":2,"score":0.9175128936767578},{"id":"https://openalex.org/C2781060337","wikidata":"https://www.wikidata.org/wiki/Q462174","display_name":"Hydrate","level":2,"score":0.5947820544242859},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5520381331443787},{"id":"https://openalex.org/C2775950743","wikidata":"https://www.wikidata.org/wiki/Q422755","display_name":"Chloral","level":2,"score":0.5319317579269409},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5274396538734436},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.43080341815948486},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.4146421253681183},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40109044313430786},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24854007363319397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1659160852432251},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09897857904434204},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07787632942199707}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002697","descriptor_name":"Chloral Hydrate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009609","descriptor_name":"Nitrous Oxide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011581","descriptor_name":"Psychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2168025","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2168025","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesth Prog","raw_type":"Text"},{"id":"pmid:3166349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3166349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia progress","raw_type":"Journal Article"},{"id":"mag:2409953256","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3166349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2168025","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2168025","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesth Prog","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W18520621","https://openalex.org/W170104263","https://openalex.org/W1840258664","https://openalex.org/W1981219928","https://openalex.org/W2035644759","https://openalex.org/W2036096547","https://openalex.org/W2073457053","https://openalex.org/W2080127546","https://openalex.org/W2125257977","https://openalex.org/W2129760514","https://openalex.org/W2396674253","https://openalex.org/W2402659291","https://openalex.org/W2404782087","https://openalex.org/W2407083965","https://openalex.org/W2408997378","https://openalex.org/W2409497005"],"related_works":["https://openalex.org/W1973368707","https://openalex.org/W2036096547","https://openalex.org/W1555502034","https://openalex.org/W3214561483","https://openalex.org/W2098638088","https://openalex.org/W7045342173","https://openalex.org/W2011797714","https://openalex.org/W2039542537","https://openalex.org/W2060336422","https://openalex.org/W7036181407"],"abstract_inverted_index":{"The":[0],"effects":[1],"of":[2,20,32,37,49,57,75,98,102],"chloral":[3,99,108],"hydrate":[4,40,109],"and/or":[5],"nitrous":[6,89,124],"oxide":[7,66,90],"were":[8,87],"assessed":[9],"in":[10,46,54,72,81],"the":[11,18,30,47,55,62,73,84,94],"mouse":[12],"staircase":[13],"test.":[14],"In":[15],"this":[16],"paradigm,":[17],"number":[19,31,48,56,74],"steps":[21,58,76],"ascended":[22,59,77],"is":[23,34],"thought":[24],"to":[25,92],"reflect":[26],"locomotor":[27],"activity,":[28],"whereas":[29],"rears":[33,50],"an":[35],"index":[36],"anxiety.":[38],"Chloral":[39],"alone":[41,67],"produced":[42,68],"a":[43,69,111],"dose-dependent":[44],"decrease":[45],"but":[51,78],"no":[52,79],"change":[53,80],"except":[60],"at":[61],"highest":[63],"dose.":[64],"Nitrous":[65],"concentration-related":[70],"increase":[71],"rearing.":[82],"When":[83],"two":[85],"drugs":[86],"combined,":[88],"appeared":[91],"potentiate":[93],"rearing":[95],"suppressant":[96],"activity":[97],"hydrate.":[100],"Analysis":[101],"our":[103],"experimental":[104],"findings":[105],"suggests":[106],"that":[107,116],"exerts":[110],"specific":[112],"anxiolytic":[113],"drug":[114],"effect":[115],"can":[117],"be":[118],"potentiated":[119],"by":[120],"concurrent":[121],"treatment":[122],"with":[123],"oxide.":[125]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
