{"id":"https://openalex.org/W2409916348","doi":null,"title":"c-myc expression is activated by the immunoglobulin kappa-enhancers from a distance of at least 30 kb but not by elements located within 50 kb of the unaltered c-myc locus in vivo.","display_name":"c-myc expression is activated by the immunoglobulin kappa-enhancers from a distance of at least 30 kb but not by elements located within 50 kb of the unaltered c-myc locus in vivo.","publication_year":1996,"publication_date":"1996-03-21","ids":{"openalex":"https://openalex.org/W2409916348","mag":"2409916348","pmid":"https://pubmed.ncbi.nlm.nih.gov/8649832"},"language":"en","primary_location":{"id":"pmid:8649832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8649832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020317705","display_name":"Josef Mautner","orcid":"https://orcid.org/0000-0002-8680-1065","observed_orcids":["https://orcid.org/0000-0002-8680-1065"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Mautner","raw_affiliation_strings":["Institut f\u00fcr Klinische Molekularbiologie und Tumorgenetik, GSF-Forschungszentrum f\u00fcr Umwelt und Gesundheit GmbH, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Klinische Molekularbiologie und Tumorgenetik, GSF-Forschungszentrum f\u00fcr Umwelt und Gesundheit GmbH, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030054330","display_name":"Uta Behrends","orcid":"https://orcid.org/0000-0002-8693-4386","observed_orcids":["https://orcid.org/0000-0002-8693-4386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Behrends","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039704214","display_name":"Konstanze H\u00f6rtnagel","orcid":"https://orcid.org/0000-0002-5511-5687","observed_orcids":["https://orcid.org/0000-0002-5511-5687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K H\u00f6rtnagel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025694365","display_name":"Markus Brielmeier","orcid":"https://orcid.org/0000-0002-8715-869X","observed_orcids":["https://orcid.org/0000-0002-8715-869X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Brielmeier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090277402","display_name":"Wolfgang Hammerschmidt","orcid":"https://orcid.org/0000-0002-4659-0427","observed_orcids":["https://orcid.org/0000-0002-4659-0427"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Hammerschmidt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039723975","display_name":"Lothar J. Strobl","orcid":"https://orcid.org/0000-0001-8389-1862","observed_orcids":["https://orcid.org/0000-0001-8389-1862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Strobl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071708949","display_name":"Bornkamm Gw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G W Bornkamm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061809859","display_name":"Axel Polack","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Polack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9548,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.71424491,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":"6","first_page":"1299","last_page":"307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8579999804496765},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/c-myc-promoter","display_name":"c-myc promoter","score":0.6000000238418579},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.39399999380111694},{"id":"https://openalex.org/keywords/b-cell-lines","display_name":"B-cell lines","score":0.6589999794960022},{"id":"https://openalex.org/keywords/chromatin-looping","display_name":"chromatin looping","score":0.3930000066757202},{"id":"https://openalex.org/keywords/regulatory-elements","display_name":"regulatory elements","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8965473771095276},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.8188440799713135},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.7430707812309265},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6121754050254822},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6096040606498718},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5511868596076965},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5047072172164917},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.45255836844444275},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4387577176094055},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4238338768482208},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.419533908367157},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4127751588821411},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3539409637451172},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002051","descriptor_name":"Burkitt Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002877","descriptor_name":"Chromosomes, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007145","descriptor_name":"Immunoglobulin kappa-Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007145","descriptor_name":"Immunoglobulin kappa-Chains","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015226","descriptor_name":"Dinucleoside Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8649832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8649832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:2409916348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8649832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2341700215","https://openalex.org/W1984801888","https://openalex.org/W1984531377","https://openalex.org/W2109291340","https://openalex.org/W2412813834","https://openalex.org/W2419643754","https://openalex.org/W2199096890","https://openalex.org/W2099539322","https://openalex.org/W4318472996","https://openalex.org/W1968343984"],"abstract_inverted_index":{"50":[0,163],"kb":[1,15,164],"of":[2,16,40,44,64,77,101,113,117,149],"contiguous":[3],"DNA":[4,41],"sequences":[5,21],"covering":[6],"the":[7,37,61,75,88,111,118,135],"human":[8],"c-myc":[9,65,80,91,126,136,150],"coding":[10],"region":[11],"and":[12,19,36,121,155,166],"approximately":[13],"20":[14],"flanking":[17],"upstream":[18],"downstream":[20],"were":[22],"cloned":[23],"onto":[24],"a":[25,33,108],"prokaryotic":[26],"F-factor":[27],"derived":[28],"plasmid,":[29],"which":[30],"also":[31],"contains":[32],"selectable":[34],"marker":[35],"plasmid":[38],"origin":[39],"replication":[42],"oriP":[43],"Epstein":[45],"Barr":[46],"virus":[47],"(EBV).":[48],"Since":[49],"these":[50,84,102],"plasmids":[51,103],"replicate":[52],"extrachromosomally":[53],"after":[54],"stable":[55],"transfection":[56],"into":[57],"EBV-positive":[58],"B-cell":[59],"lines,":[60],"gene":[62,92,114],"regulation":[63],"can":[66],"be":[67,105],"analysed":[68],"independent":[69],"from":[70,87,134],"chromosomal":[71],"integration":[72],"positions.":[73],"Despite":[74],"presence":[76],"all":[78],"known":[79],"regulatory":[81],"elements":[82,159],"on":[83],"constructs,":[85],"expression":[86],"stably":[89],"transfected":[90],"was":[93],"barely":[94],"detectable":[95],"in":[96,151,173],"either":[97],"cell":[98],"line.":[99],"Hypermethylation":[100],"could":[104],"excluded":[106],"as":[107,139,141],"mechanism":[109],"for":[110],"lack":[112],"expression.":[115],"Insertion":[116],"immunoglobulin":[119],"kappa-intron":[120],"3'":[122],"enhancers,":[123],"however,":[124],"activated":[125],"transcription,":[127],"when":[128],"placed":[129],"adjacent":[130],"to":[131],"or":[132],"separated":[133],"promoters":[137],"by":[138],"far":[140],"30":[142],"kb.":[143],"These":[144],"results":[145],"indicate":[146],"that":[147],"transcription":[148],"vivo":[152],"requires":[153],"additional":[154],"still":[156],"unidentified":[157],"control":[158],"located":[160],"outside":[161],"this":[162],"fragment,":[165],"experimentally":[167],"demonstrate":[168],"long":[169],"range":[170],"enhancer":[171],"function":[172],"vivo.":[174]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}