{"id":"https://openalex.org/W2409914976","doi":null,"title":"Lower adrenocortical and adrenomedullary responses to hypoglycemia in premenopausal women with systemic sclerosis.","display_name":"Lower adrenocortical and adrenomedullary responses to hypoglycemia in premenopausal women with systemic sclerosis.","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W2409914976","mag":"2409914976","pmid":"https://pubmed.ncbi.nlm.nih.gov/17086608"},"language":"en","primary_location":{"id":"pmid:17086608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17086608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080038163","display_name":"Richard Imrich","orcid":"https://orcid.org/0000-0002-1747-7150","observed_orcids":["https://orcid.org/0000-0002-1747-7150"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210104728","display_name":"Institute of Experimental Endocrinology of the Slovak Academy of Sciences","ror":"https://ror.org/01a1nz002","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210104728","https://openalex.org/I4210123996"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Richard Imrich","raw_affiliation_strings":["Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia. richard.imrich@savba.sk","Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vl\u00e1rska 3, 833 06 Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia. richard.imrich@savba.sk","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210104728"]},{"raw_affiliation_string":"Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vl\u00e1rska 3, 833 06 Bratislava, Slovakia","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210104728"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jozef Lukac","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jozef Lukac","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066306496","display_name":"Jozef Rovensk\u00fd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jozef Rovensky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061890126","display_name":"\u017dofia R\u00e1dikov\u00e1","orcid":"https://orcid.org/0000-0002-3191-656X","observed_orcids":["https://orcid.org/0000-0002-3191-656X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zofia Radikova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015726258","display_name":"Adela Penesov\u00e1","orcid":"https://orcid.org/0000-0002-9651-7340","observed_orcids":["https://orcid.org/0000-0002-9651-7340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adela Penesova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016840247","display_name":"Richard Kv\u011bt\u0148ansk\u00fd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Kvetnansky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017140025","display_name":"Miroslava Hu\u010dkov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miroslava Huckova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109071147","display_name":"Milan Vigas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Milan Vigas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085221142","display_name":"Ladislav Macho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ladislav Macho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109148559","display_name":"Juraj Ko\u0161ka","orcid":"https://orcid.org/0000-0002-6671-6250","observed_orcids":["https://orcid.org/0000-0002-6671-6250"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juraj Koska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7653,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.7197182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"33","issue":"11","first_page":"2235","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.4004000127315521,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/insulin-induced-hypoglycemia","display_name":"insulin-induced hypoglycemia","score":0.9390000104904175},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.7960000038146973},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9070000052452087},{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":0.7609999775886536},{"id":"https://openalex.org/keywords/17-hydroxyprogesterone","display_name":"17-hydroxyprogesterone","score":0.8220000267028809},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.8960000276565552},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.8450000286102295},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.42800000309944153},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6389999985694885},{"id":"https://openalex.org/keywords/glucocorticoid-resistance","display_name":"glucocorticoid resistance","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8847337961196899},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8794946670532227},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8638170957565308},{"id":"https://openalex.org/C2780657110","wikidata":"https://www.wikidata.org/wiki/Q2505402","display_name":"Dehydroepiandrosterone sulfate","level":4,"score":0.7613532543182373},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.6246920824050903},{"id":"https://openalex.org/C2776992908","wikidata":"https://www.wikidata.org/wiki/Q408376","display_name":"Dehydroepiandrosterone","level":4,"score":0.6057758331298828},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.49761274456977844},{"id":"https://openalex.org/C2776683971","wikidata":"https://www.wikidata.org/wiki/Q411064","display_name":"Androstenedione","level":4,"score":0.48362791538238525},{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.46394965052604675},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.45846542716026306},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4324076771736145},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.4254509210586548},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4218132495880127},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.31798338890075684},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.22957521677017212}],"mesh":[{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000313","descriptor_name":"Adrenal Medulla","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000735","descriptor_name":"Androstenedione","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017697","descriptor_name":"Premenopause","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17086608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17086608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},{"id":"mag:2409914976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17086608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W82578648","https://openalex.org/W110074308","https://openalex.org/W271233216","https://openalex.org/W1963989474","https://openalex.org/W1967333454","https://openalex.org/W1985064196","https://openalex.org/W1993188295","https://openalex.org/W1999241720","https://openalex.org/W2006724319","https://openalex.org/W2006788197","https://openalex.org/W2016210314","https://openalex.org/W2021093010","https://openalex.org/W2025450752","https://openalex.org/W2044622793","https://openalex.org/W2047026751","https://openalex.org/W2052905415","https://openalex.org/W2060891247","https://openalex.org/W2067917639","https://openalex.org/W2071765890","https://openalex.org/W2085075882","https://openalex.org/W2085118254","https://openalex.org/W2087605866","https://openalex.org/W2089583674","https://openalex.org/W2092844763","https://openalex.org/W2097866678","https://openalex.org/W2114699150","https://openalex.org/W2132861041","https://openalex.org/W2135514207","https://openalex.org/W2136290209","https://openalex.org/W2141835651","https://openalex.org/W2143856183","https://openalex.org/W2161807512","https://openalex.org/W2299513640","https://openalex.org/W2395690513","https://openalex.org/W2421812812"],"related_works":["https://openalex.org/W2109335870","https://openalex.org/W2132861041","https://openalex.org/W2031699416","https://openalex.org/W1994131205","https://openalex.org/W1975786788","https://openalex.org/W1272328312","https://openalex.org/W2397952240","https://openalex.org/W49434772","https://openalex.org/W4248656726","https://openalex.org/W2049312388"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"evaluate":[2],"function":[3],"of":[4,56,92,174,196],"the":[5,194,259,263],"hypothalamic-pituitary-adrenal":[6],"(HPA)":[7],"axis,":[8],"adrenomedullary":[9,251],"hormonal":[10],"system":[11,16,265],"(AMHS),":[12],"and":[13,42,50,79,99,150,176,188,213,250],"sympathetic":[14],"noradrenergic":[15],"(SNS)":[17],"in":[18,32,43,86,105,119,126,138,145,158,165,222,235,253,262],"premenopausal":[19,254],"women":[20,46,255],"with":[21,38,186,256],"systemic":[22],"sclerosis":[23],"(SSc).":[24],"METHODS:":[25],"Insulin-induced":[26],"hypoglycemia":[27,219,230],"(0.1":[28],"IU/kg)":[29],"was":[30],"performed":[31],"17":[33],"longterm,":[34],"glucocorticoid-naive":[35],"SSc":[36,106,120,139,159,223,236],"patients":[37,237],"low":[39],"disease":[40,270],"activity":[41],"18":[44],"healthy":[45],"matched":[47],"for":[48,183],"age":[49,189],"body":[51],"mass":[52],"index":[53],"(BMI).":[54],"Concentrations":[55],"glucose,":[57],"adrenocorticotrophic":[58],"hormone":[59],"(ACTH),":[60],"cortisol,":[61,93],"androstenedione":[62],"(ASD),":[63],"dehydroepiandrosterone":[64,66],"(DHEA),":[65],"sulfate":[67],"(DHEAS),":[68],"17a-hydroxyprogesterone":[69],"(17OHP),":[70],"epinephrine":[71],"(EPI),":[72],"norepinephrine":[73],"(NE),":[74],"interleukin":[75],"1ss":[76],"(IL-1ss),":[77],"IL-6,":[78,98],"tumor":[80],"necrosis":[81],"factor-a":[82],"(TNF-a)":[83],"were":[84,101,220],"analyzed":[85],"plasma.":[87],"RESULTS:":[88],"Basal":[89],"plasma":[90],"levels":[91],"ASD,":[94],"17OHP,":[95],"DHEAS,":[96],"IL-1ss,":[97],"TNF-a":[100],"not":[102],"significantly":[103],"different":[104],"compared":[107,224,241],"to":[108,178,218,225,229,232,242,268],"controls.":[109,226,243],"Patients":[110,170],"had":[111,171],"higher":[112],"basal":[113,132,152],"ACTH":[114,177],"(6.76":[115],"+/-":[116,123,135,142,155,162],"1.0":[117],"pmol/l":[118,125],"vs":[121,140,160],"4.14":[122],"0.45":[124],"controls;":[127,146,166],"p":[128,147,167],"<":[129,148,168,199,203,207,211,216],"0.05),":[130,149,200,204],"lower":[131,151,221,234],"DHEA":[133,205],"(9.02":[134],"1.64":[136],"nmol/l":[137,144,157,164],"17.0":[141],"2.8":[143],"NE":[153,214],"(1.61":[154],"0.26":[156],"2.57":[161],"0.38":[163],"0.05).":[169],"comparable":[172],"responses":[173,195],"glucose":[175],"hypoglycemia.":[179],"General":[180],"linear":[181],"model":[182],"repeated":[184],"measurements,":[185],"BMI":[187],"as":[190],"covariates,":[191],"revealed":[192],"that":[193],"17OHP":[197],"(p":[198,202,206,210,215,238],"ASD":[201],"0.01),":[208],"EPI":[209],"0.001),":[212],"0.001)":[217],"Cortisol":[227],"response":[228],"tended":[231],"be":[233],"=":[239],"0.06)":[240],"CONCLUSION:":[244],"Our":[245],"data":[246],"indicate":[247],"decreased":[248],"adrenocortical":[249],"functions":[252],"SSc.":[257],"Whether":[258],"observed":[260],"changes":[261],"neuroendocrine":[264],"are":[266],"secondary":[267],"chronic":[269],"deserves":[271],"further":[272],"investigation.":[273]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
