{"id":"https://openalex.org/W2409816004","doi":null,"title":"Maternal Diabetes as It Affects Extracellular Matrix Deposition in the Embryonic Mouse Heart","display_name":"Maternal Diabetes as It Affects Extracellular Matrix Deposition in the Embryonic Mouse Heart","publication_year":2004,"publication_date":"2004-11-02","ids":{"openalex":"https://openalex.org/W2409816004","mag":"2409816004"},"language":"en","primary_location":{"id":"pmh:oai:repository.lib.ncsu.edu:1840.16/3312","doi":null,"is_oa":false,"landing_page_url":"http://www.lib.ncsu.edu/resolver/1840.16/3312","pdf_url":null,"source":{"id":"https://openalex.org/S4306402468","display_name":"NCSU Libraries Repository (North Carolina State University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I137902535","host_organization_name":"North Carolina State University","host_organization_lineage":["https://openalex.org/I137902535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020916918","display_name":"Nia Joyner Bullock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nia Joyner Bullock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5020916918"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.40380001068115234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":0.9819999933242798},{"id":"https://openalex.org/keywords/maternal-diabetes","display_name":"maternal diabetes","score":0.7919999957084656},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.7620000243186951},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/diabetic-embryopathy","display_name":"diabetic embryopathy","score":0.6869999766349792},{"id":"https://openalex.org/keywords/glut1-expression","display_name":"GLUT1 expression","score":0.6759999990463257},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7319999933242798},{"id":"https://openalex.org/keywords/embryonic-heart-development","display_name":"embryonic heart development","score":0.7099999785423279},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.6100000143051147},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.34200000762939453},{"id":"https://openalex.org/keywords/cardiac-abnormalities","display_name":"cardiac anomalies","score":0.3970000147819519},{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.5379999876022339},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.34299999475479126},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7779708504676819},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6105743646621704},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5896981358528137},{"id":"https://openalex.org/C2777837822","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Embryonic heart","level":4,"score":0.5363579392433167},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4951900541782379},{"id":"https://openalex.org/C64297162","wikidata":"https://www.wikidata.org/wiki/Q1987070","display_name":"Deposition (geology)","level":3,"score":0.4938846230506897},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.42040276527404785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3896755874156952},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36049917340278625},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34941565990448},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34937015175819397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3278818130493164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16654640436172485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07899242639541626},{"id":"https://openalex.org/C2816523","wikidata":"https://www.wikidata.org/wiki/Q180184","display_name":"Sediment","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.lib.ncsu.edu:1840.16/3312","doi":null,"is_oa":false,"landing_page_url":"http://www.lib.ncsu.edu/resolver/1840.16/3312","pdf_url":null,"source":{"id":"https://openalex.org/S4306402468","display_name":"NCSU Libraries Repository (North Carolina State University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I137902535","host_organization_name":"North Carolina State University","host_organization_lineage":["https://openalex.org/I137902535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"mag:2409816004","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/ETH/3167","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":167,"referenced_works":["https://openalex.org/W69873029","https://openalex.org/W107731324","https://openalex.org/W195577281","https://openalex.org/W1257903918","https://openalex.org/W1513205519","https://openalex.org/W1519072726","https://openalex.org/W1559834502","https://openalex.org/W1574495339","https://openalex.org/W1595561754","https://openalex.org/W1648100608","https://openalex.org/W1663371441","https://openalex.org/W1733360926","https://openalex.org/W1898250799","https://openalex.org/W1934555047","https://openalex.org/W1951862796","https://openalex.org/W1963715575","https://openalex.org/W1963840316","https://openalex.org/W1965482152","https://openalex.org/W1966253758","https://openalex.org/W1966908061","https://openalex.org/W1967064176","https://openalex.org/W1967255096","https://openalex.org/W1969659129","https://openalex.org/W1971343950","https://openalex.org/W1972511728","https://openalex.org/W1974432608","https://openalex.org/W1974890922","https://openalex.org/W1975196627","https://openalex.org/W1978583190","https://openalex.org/W1980480613","https://openalex.org/W1981252803","https://openalex.org/W1982606879","https://openalex.org/W1983678974","https://openalex.org/W1983729225","https://openalex.org/W1985479666","https://openalex.org/W1985857585","https://openalex.org/W1986891553","https://openalex.org/W1990923018","https://openalex.org/W1992093442","https://openalex.org/W1994602446","https://openalex.org/W1995514635","https://openalex.org/W1996577549","https://openalex.org/W1996839970","https://openalex.org/W1998118848","https://openalex.org/W1999676854","https://openalex.org/W1999843107","https://openalex.org/W1999884246","https://openalex.org/W2000638908","https://openalex.org/W2001303381","https://openalex.org/W2002596946","https://openalex.org/W2003470891","https://openalex.org/W2008160100","https://openalex.org/W2008257508","https://openalex.org/W2009407308","https://openalex.org/W2010601468","https://openalex.org/W2010709317","https://openalex.org/W2011757394","https://openalex.org/W2014614057","https://openalex.org/W2017795402","https://openalex.org/W2017888726","https://openalex.org/W2018364757","https://openalex.org/W2021995513","https://openalex.org/W2023714433","https://openalex.org/W2023970316","https://openalex.org/W2024051243","https://openalex.org/W2024792037","https://openalex.org/W2025029102","https://openalex.org/W2027115595","https://openalex.org/W2030146545","https://openalex.org/W2030580477","https://openalex.org/W2031259147","https://openalex.org/W2031780222","https://openalex.org/W2034293014","https://openalex.org/W2034342873","https://openalex.org/W2036546315","https://openalex.org/W2037586059","https://openalex.org/W2038028237","https://openalex.org/W2038735055","https://openalex.org/W2040527378","https://openalex.org/W2041600962","https://openalex.org/W2041823687","https://openalex.org/W2043406584","https://openalex.org/W2045706251","https://openalex.org/W2045974744","https://openalex.org/W2046044320","https://openalex.org/W2047528517","https://openalex.org/W2050304917","https://openalex.org/W2051133105","https://openalex.org/W2053596249","https://openalex.org/W2054676857","https://openalex.org/W2056726644","https://openalex.org/W2056794607","https://openalex.org/W2056829959","https://openalex.org/W2057928544","https://openalex.org/W2057958444","https://openalex.org/W2058063000","https://openalex.org/W2058139490","https://openalex.org/W2061108982","https://openalex.org/W2061364271","https://openalex.org/W2062777396","https://openalex.org/W2062784484","https://openalex.org/W2062909350","https://openalex.org/W2063242845","https://openalex.org/W2064150433","https://openalex.org/W2067700553","https://openalex.org/W2067789393","https://openalex.org/W2070312351","https://openalex.org/W2071917994","https://openalex.org/W2074272859","https://openalex.org/W2075181472","https://openalex.org/W2077386341","https://openalex.org/W2078840238","https://openalex.org/W2079299343","https://openalex.org/W2081878872","https://openalex.org/W2082038431","https://openalex.org/W2082055905","https://openalex.org/W2085082053","https://openalex.org/W2086315976","https://openalex.org/W2092708316","https://openalex.org/W2093081296","https://openalex.org/W2098477122","https://openalex.org/W2101933860","https://openalex.org/W2106216125","https://openalex.org/W2111158723","https://openalex.org/W2114154263","https://openalex.org/W2114328207","https://openalex.org/W2116138164","https://openalex.org/W2118938244","https://openalex.org/W2120370131","https://openalex.org/W2121727346","https://openalex.org/W2122081319","https://openalex.org/W2125812425","https://openalex.org/W2128257551","https://openalex.org/W2128635872","https://openalex.org/W2128757614","https://openalex.org/W2129554772","https://openalex.org/W2133776441","https://openalex.org/W2134467817","https://openalex.org/W2135664105","https://openalex.org/W2139336812","https://openalex.org/W2140292861","https://openalex.org/W2141974913","https://openalex.org/W2144533837","https://openalex.org/W2146559746","https://openalex.org/W2147145439","https://openalex.org/W2154066388","https://openalex.org/W2156780461","https://openalex.org/W2161544444","https://openalex.org/W2161993127","https://openalex.org/W2163390971","https://openalex.org/W2163791375","https://openalex.org/W2164778548","https://openalex.org/W2166269000","https://openalex.org/W2168650659","https://openalex.org/W2169095915","https://openalex.org/W2169804478","https://openalex.org/W2187285131","https://openalex.org/W2188422153","https://openalex.org/W2279575663","https://openalex.org/W2310739101","https://openalex.org/W2322103693","https://openalex.org/W2335187016","https://openalex.org/W2345903479","https://openalex.org/W2409614735","https://openalex.org/W2410196872","https://openalex.org/W2416125793","https://openalex.org/W4296927411"],"related_works":["https://openalex.org/W2605702331","https://openalex.org/W2004593166","https://openalex.org/W7135862861","https://openalex.org/W7097591965","https://openalex.org/W2101022511","https://openalex.org/W2059613083","https://openalex.org/W7221039277","https://openalex.org/W3110833879","https://openalex.org/W3190780062","https://openalex.org/W7018743020"],"abstract_inverted_index":{"Fibrosis":[0],"is":[1,111,116,146,257,1085],"a":[2,34,62,112,320,363,384,558,838,909,1086],"condition":[3,322],"common":[4,180],"to":[5,121,148,153,233,258,319,336,410,456,543,571,592,707,872,893,930,1000,1024,1028,1049,1092,1095],"adults":[6,240],"suffering":[7,227],"from":[8,33,142,228,244,769,1136],"diabetes":[9,108],"mellitus":[10,109],"(DM),":[11],"characterized":[12,117],"by":[13,90,118,285,451,900,1034,1052,1075],"excessive":[14],"production":[15,580],"of":[16,24,37,53,64,100,104,130,138,157,162,186,254,268,302,313,340,369,413,434,437,468,482,524,531,557,581,589,608,635,640,653,660,695,715,743,818,834,862,868,885,935,952,969,976,1044,1065,1072,1131,1143],"extracellular":[17],"matrix":[18,525,532],"(ECM)":[19],"proteins":[20,737],"in":[21,79,88,94,127,167,183,261,273,288,310,323,332,348,360,371,425,440,460,465,545,551,586,610,619,676,721,750,755,782,790,807,824,827,837,857,879,890,902,912,943,948,988,1019,1031,1080,1100,1102,1117,1146],"the":[22,73,105,119,131,155,168,178,184,216,252,262,266,274,300,311,338,349,426,447,469,476,567,579,587,620,677,693,713,741,797,808,848,866,918,933,936,940,949,974,1020,1039,1042,1063,1081,1118,1132,1141],"ECM":[23,74,217,279,290,315,470,472,517,736,895,960,971,994,1015,1046,1068,1073],"various":[25],"organs":[26,58],"and":[27,49,57,82,98,102,144,150,173,189,198,208,221,239,282,387,391,402,471,479,493,501,528,537,573,584,594,599,605,614,627,637,650,655,664,667,689,709,724,726,734,753,758,761,765,775,785,788,793,802,815,927,945,978,1004,1011,1059,1077,1097,1125],"vasculature.":[28],"Those":[29],"with":[30,236,241],"DM":[31,242],"suffer":[32,141,243],"wide":[35],"range":[36],"health":[38],"conditions":[39,246,1116],"such":[40,520],"as":[41,61,521],"peripheral":[42],"nerve":[43],"disorders,":[44,47],"retinopathy,":[45],"vascular":[46],"nephropathy,":[48],"heart":[50,96,219,237,379,561,569,771,777,811,829,1096,1120,1134],"disease.":[51],"Many":[52],"these":[54,324,735,1147],"effected":[55],"tissues":[56],"develop":[59],"fibrosis":[60,1105,1130],"result":[63],"DM,":[65],"which":[66,128,247,286,326,554,820,886,897,1056,1103,1121],"may":[67,292,327,1122,1138],"eventually":[68,328],"cause":[69],"tissue":[70,83,489,529],"dysfunction.":[71,1108],"As":[72],"plays":[75],"an":[76,308,431,550,822,1029],"important":[77],"role":[78],"adult":[80],"organ":[81,1107,1144],"function,":[84],"it":[85,145,962],"also":[86,747,1139],"functions":[87],"cardiogenesis":[89],"supporting":[91],"cell":[92,562,772],"migration":[93],"early":[95],"development":[97],"formation":[99,223],"septum":[101,1124],"valves":[103],"heart.":[106,623,680,1083],"\\n\\n\\tGestational":[107],"(GDM)":[110],"metabolic":[113],"disorder":[114],"that":[115,296,515,565,983,990,1088,1112],"inability":[120],"properly":[122],"metabolize":[123],"glucose":[124,271,303,344,461,825,870,1054],"using":[125,362,383,396,496,506,535,597],"insulin,":[126],"onset":[129],"disease":[132,1087],"occurs":[133],"during":[134,224],"pregnancy.":[135],"Approximately":[136],"4%":[137],"pregnant":[139,263,350,427,448],"women":[140,226],"GDM":[143,152,229,260,269,297,341,414,509,718,746,907,1113,1137],"essential":[147],"treat":[149],"control":[151],"lessen":[154],"risk":[156],"diabetic":[158,163,187,450,954],"embryopathy.":[159],"Common":[160],"manifestations":[161],"embryopathy":[164],"are":[165,177,193,230,887],"malformations":[166,176],"developing":[169,1119,1133],"heart,":[170,276],"spine,":[171],"brain":[172],"lungs.":[174],"Heart":[175],"most":[179,956],"defects":[181],"observed":[182,856,899,1008],"offspring":[185,235,325],"mothers,":[188],"they":[190],"include,":[191],"but":[192,705],"not":[194,842,964],"limited":[195],"to,":[196],"atrial":[197],"ventricular":[199],"septal":[200,211,222],"defects,":[201,204,207,238],"outflow":[202],"tract":[203],"cardiac":[205,249,278,289,305,314,330,343,388,477,522,644,728,751,756,874,882,903,913,970,993,1002,1067],"valve":[206,220,1126],"increased":[209,618,672,685,701,806,869,894,959,1012,1045,1066],"interventricular":[210],"thickness.":[212],"\\n\\nAs":[213],"stated":[214],"previously,":[215],"supports":[218],"cardiogenesis,":[225],"more":[231],"likely":[232,957],"have":[234,1110],"fibrotic":[245,321],"affect":[248,1123],"function.":[250],"\\n\\nTherefore,":[251],"goal":[253],"this":[255],"dissertation":[256],"model":[259,553],"mouse,":[264,351,428],"explore":[265],"effects":[267],"on":[270,342,373,443],"transport":[272,301,462],"embryonic":[275,560,568,621,678,770,776,809,828,1021,1082],"examine":[277,337,411,1001],"protein":[280,380,390,478,518,613,626,645,666,682,729,760,784,792,801,915,1070],"expression":[281,312,347,393,473,481,523,616,629,669,683,699,730,787,804,916,923,947,1047],"reveal":[283],"mechanisms":[284,514,987],"alterations":[287],"deposition":[291,519],"occur.":[293],"We":[294,576,1007,1109],"propose":[295,1038],"will":[298],"alter":[299],"into":[304],"cells,":[306],"causing":[307],"alteration":[309],"proteins,":[316],"potentially":[317],"leading":[318,892],"influence":[329,1140],"function":[331,1099,1145],"adulthood.":[333],"\\n\\nIn":[334,408],"order":[335],"effect":[339],"transporter-1":[345],"(Glut-1)":[346],"we":[352,429,474,511,548,1037],"induced":[353,463,958],"hyperglycemia":[354,609,636,654],"for":[355,415,932],"6":[356,364,420,604,649,814],"or":[357,422,657],"12":[358,606,633,638,651,658,816,845],"hours":[359,607,634,639,652,659,675,688,704,733,817,846,861],"vivo":[361,546],"g/kg":[365],"intraperitoneal":[366],"(IP)":[367],"injection":[368,433],"D-glucose":[370],"saline":[372],"gestational":[374],"day":[375],"(gd)":[376],"9.5.":[377,453],"Total":[378],"was":[381,394,555,646,684,700,805,898,924,1017],"measured":[382,395],"Bradford":[385],"assay":[386],"Glut-1":[389,612,625,800,836],"gene":[392,480,615,628,668,698,762,786,794,803,922],"immunohistochemistry":[397],"(IHC),":[398],"SDS-PAGE":[399,498],"Western":[400,499],"analysis,":[401,500],"Reverse":[403],"Transcriptase-Polymerase":[404],"Chain":[405],"Reaction":[406],"(RT-PCR).":[407],"efforts":[409,455],"durations":[412],"24":[416,674,687,703,732,860],"hours,":[417,419],"48":[418],"days":[421,424],"9":[423],"administered":[430],"IP":[432],"250":[435],"mg/kg":[436],"streptozotocin":[438],"(STZ)":[439],"citrate":[441],"buffer":[442],"gd":[444,452],"7.5,":[445],"rendering":[446],"mouse":[449,622,679,810],"In":[454,541,1128],"discover":[457],"whether":[458],"changes":[459,464],"key":[466,888],"regulators":[467],"examined":[475],"transforming":[483],"growth":[484,490],"factor":[485,491],"beta-1":[486],"(TGF\u03b2-1),":[487],"connective":[488],"(CTGF),":[492],"fibronectin":[494],"(FN)":[495],"IHC,":[497],"Real":[502,538,766],"time":[503,539],"RT-PCR.":[504,540],"\\n\\nFinally,":[505],"our":[507,544,953],"STZ-induced":[508,745,863,906,1025],"model,":[510,547],"explored":[512],"other":[513,986],"support":[516],"metalloproteinases":[526,533],"(MMP)":[527],"inhibitors":[530],"(TIMP)":[534],"IHC":[536],"addition":[542],"used":[549],"vitro":[552],"comprised":[556],"primary":[559],"culture":[563,773],"system":[564],"exposed":[566,591,1023],"cells":[570,590,778],"normoglycemic":[572,595],"hyperglycemic":[574,593,798,839,849],"conditions.":[575],"then":[577,928],"compared":[578],"MMPs,":[582],"TIMPs":[583,1013,1078],"FN":[585,681,904,914],"media":[588,774],"conditions,":[596],"ELISA":[598,764],"Real-Time":[600],"PCR.":[601],"\\n\\nImmediately":[602],"following":[603,632,648,813,859,1040],"vivo,":[611],"were":[617,630,670,985],"Cardiac":[624],"decreased":[631,647,1009],"normoglycemia":[641],"while":[642,697,921],"total":[643],"18":[656],"normoglycemia,":[661],"respectively.":[662],"\\n\\nTGF\u03b2-1":[663],"CTGF":[665,946,1060],"collectively":[671],"at":[673,686,702,731],"remained":[690,710,738],"elevated":[691,739,1053],"until":[692,740,844],"end":[694,742],"gestation,":[696],"returned":[706,929],"normal":[708,931],"unchanged":[711],"throughout":[712,917],"remainder":[714,934],"gestation.":[716,744],"\\n\\nSTZ-induced":[717],"produced":[719,748],"increases":[720,754,789,901],"Collagen":[722],"IV":[723],"V,":[725],"laminin":[727],"decreases":[749,781],"MMP-2":[752,783],"TIMP1-2,":[757],"3":[759],"expression.":[763,795,876,905,1006,1061],"Time-PCR":[767],"results":[768,981],"respectively,":[779],"demonstrated":[780],"TIMP-1":[791],"\\n\\nDespite":[796],"condition,":[799],"immediately":[812],"hyperglycemia,":[819],"suggests":[821],"increase":[823,855,911,1030],"uptake":[826,871],"cells.":[830],"The":[831,980],"compensatory":[832],"measure":[833],"decreasing":[835],"environment":[840],"did":[841,963],"occur":[843,1079],"after":[847],"insult":[850],"has":[851,1089],"passed.":[852],"\\n\\nThe":[853],"brief":[854,941],"TGF\u03b2-1":[858,875,877,944,977,1058],"GDM,":[864,1026],"suggest":[865],"ability":[867],"induce":[873,881,1057],"would":[878],"turn":[880],"CTGF,":[883],"all":[884],"mediators":[889],"pathways":[891],"deposition,":[896],"caused":[908,1051],"continuous":[910],"treatment":[919,937],"period,":[920],"up-regulated":[925],"briefly":[926],"period.":[938],"Although,":[939],"elevation":[942],"earlier":[950],"stages":[951],"exposure":[955],"production,":[961,1069],"however":[965],"explain":[966],"continued":[967],"up-regulation":[968],"components":[972,1074],"despite":[973],"normalization":[975],"CTGF.":[979],"suggested":[982],"there":[984],"place":[989],"post-translationally":[991],"stabilize":[992],"proteins.":[995],"These":[996],"findings":[997],"lead":[998],"us":[999],"MMP":[1003,1032],"TIMP":[1005],"MMPs":[1010,1076],"suggesting":[1014],"degradation":[1016],"diminished":[1018],"hearts":[1022],"due":[1027],"inhibition":[1033],"TIMPs.":[1035],"Thus,":[1036],"model;":[1041],"initiation":[1043,1064],"appears":[1048],"be":[1050,1093],"levels":[1055],"Following":[1062],"stabilization":[1071],"\\n\\nDM":[1084],"been":[1090],"proven":[1091],"detrimental":[1094],"kidney":[1098],"adults,":[1101],"associated":[1104],"causes":[1106,1114],"shown":[1111],"pre-fibrotic":[1115],"formation.":[1127],"addition,":[1129],"resulting":[1135],"efficiency":[1142],"offspring.":[1148]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
